Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
Cefsulodin is a bacterial inhibitor primarily targeting Pseudomonas aeruginosa. It exhibits potent antimicrobial activity against penicillin-susceptible and gentamicin-sensitive strains, demonstrating effectiveness comparable to gentamicin and debendazole. However, Cefsulodin's efficacy is reduced against penicillin-resistant strains of P. aeruginosa, particularly those also resistant to gentamicin. The compound shows a similar minimum inhibitory concentration for P. aeruginosa maltofila when compared to penicillin, gentamicin, and debendazole, while Pseudomonas cepacia strains typically present moderate resistance to Cefsulodin. Its applications include evaluating bacterial resistance mechanisms and antibiotic efficacy in clinical microbiology. -
Antibiotic
Avilamycin A is an orally active antibiotic that targets bacterial pathogens, particularly effective against veterinary strains of Clostridium perfringens (MICs ≤ 0.06-0.5 mg/L) and Brachyspira hyodysenteriae (MICs = 12.5-100 μg/ml). Its potent antibacterial properties make it a valuable reagent for research focused on combating bacterial infections in veterinary medicine. Avilamycin A is often utilized in studies aiming to understand antibiotic resistance mechanisms and to develop new therapeutic strategies against resistant bacterial strains. -
Antibiotic
(R)-10,11-Dehydrocurvularin is an antibiotic derived from the secondary metabolites of Curvularia species. It exhibits concentration-dependent cytotoxicity against various human tumor cell lines, with a mean IC50 value of 1.25 µM. This compound is valuable for research applications in cancer biology and the development of novel antimicrobial agents. -
Antibiotic
Erythromycin C is an antibiotic that primarily targets bacterial protein synthesis by binding to the 50S ribosomal subunit. It exhibits potent activity against a wide range of gram-positive bacteria and some gram-negative pathogens. Erythromycin C is widely used in research to study bacterial resistance mechanisms and as a model compound in antibiotic development studies. Its properties make it a valuable tool in microbiological and pharmaceutical research. -
Diterpene Ester
12-Deoxyphorbol-13-isobutyrate-20-acetate is a diterpene ester that functions as a selective agonist of protein kinase C (PKC). It effectively activates PKC to facilitate the phosphorylation of troponin I and troponin T, contributing to key regulatory pathways in cardiac function. Additionally, this compound has been shown to induce dermal irritation and necrosis in murine models while demonstrating no cocarcinogenic activity. Furthermore, 12-Deoxyphorbol-13-isobutyrate-20-acetate exhibits inhibitory effects on the growth of Aspergillus carbonarius, making it valuable for research in heart failure, cardiomyopathies, and fungal infections. -
Antifugal Agent
Polyoxin D is a potent antifungal agent that acts as a chitin synthetase inhibitor. By disrupting chitin synthesis in fungal cell walls, it effectively inhibits fungal growth and proliferation. This compound is primarily utilized in research settings to study fungal pathogenesis and to explore potential therapeutic strategies against fungal infections. -
Bacterial Inhibitor
Ampicillin is a broad-spectrum beta-lactam antibiotic that targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable reagent in microbiological research and antibiotic susceptibility testing. Ampicillin is commonly used to study bacterial resistance mechanisms and is also employed in molecular biology for the selection of recombinant plasmids in cloning applications. -
SPT Inhibitor
Myriocin is a potent serine palmitoyltransferase (SPT) inhibitor derived from various fungal species such as Myriococcum albomyces, Isaria sinclairi, and Mycelia sterilia. By inhibiting SPT, Myriocin plays a crucial role in the disruption of de novo sphingolipid synthesis. It has demonstrated significant antiviral activity, effectively suppressing the replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL. This compound is valuable for research into sphingolipid metabolism and hepatitis C virus infection mechanisms. -
Antibiotic
Concanamycin A is a macrolide antibiotic that functions as an inhibitor of vacuolar type H+-ATPase (V-ATPase). By inhibiting V-ATPase, Concanamycin A disrupts lysosomal acidification, making it a valuable tool in the study of T cell-mediated inflammation. Its properties allow for exploration of cellular processes related to inflammation and lysosomal function, contributing to a better understanding of various disease mechanisms. -
Antibiotic
Streptomycin is an aminoglycoside antibiotic primarily targeting bacterial protein synthesis by binding to ribosomal RNA. It exhibits potent activity against Mycobacterium tuberculosis, making it essential for tuberculosis research. In addition, Streptomycin demonstrates bactericidal properties against various bacterial infections and interferes with nucleic acid interactions. Furthermore, this compound acts as a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes, enabling its use in studies related to electrophysiological processes. -
Antifolate Agent, Antibacterial Agent
11-Oxahomoaminopterin is an antifolate agent that inhibits dihydrofolate reductase, targeting bacterial and tumor cell proliferation. This compound exhibits significant antibacterial activity against Lactobacillus casei, demonstrating potential applications in antimicrobial and antitumor research. Its ability to interfere with folate metabolism makes it a valuable tool for studying various biological systems. -
Antibacterial Agent
Antibacterial Agent 330 is an antibacterial compound that operates by inducing reactive oxygen species (ROS) accumulation and forming supramolecular complexes through DNA intercalation, which inhibits DNA replication. This agent disrupts bacterial metabolism by inhibiting lactate dehydrogenase (LDH) and promotes cell lysis, resulting in the leakage of intracellular contents and bacterial cell death. Antibacterial Agent 330 demonstrates significant antibacterial activity and enhances wound healing in both Galleria mellonella larval and murine models, making it a valuable tool for researching bacterial infections. -
Antifungal Agent
Fluoxastrobin is an antifungal agent that targets NAD-dependent epimerase/dehydratase, inhibiting electron transport and reducing ATP production, which effectively controls foliar diseases in tea plants. This compound induces oxidative stress by elevating reactive oxygen species (ROS) levels and lipid peroxidation, leading to DNA damage and apoptosis. Additionally, Fluoxastrobin exhibits high acute toxicity to Danio rerio embryos and larvae, making it a valuable tool in research related to tea foliar diseases, including tea red leaf spot and tea gray leaf spot. -
Macropinocytosis inhibitor
Virapinib is a potent macropinocytosis inhibitor that demonstrates significant antiviral activity. It effectively inhibits viral entry of a broad range of viruses, including SARS-CoV-2, monkeypox virus, tick-borne encephalitis virus, and Ebola pseudotyped vesicular stomatitis virus, while also enhancing Dengue Virus infection. By obstructing macropinocytosis, Virapinib reduces syncytium formation in SARS-CoV-2-infected cells and hinders the cellular entry of SARS-CoV-2 variants. This compound is valuable for research focused on viral pathogenesis and therapeutic evaluations related to COVID-19 and other viral infections. -
SAR Inducer
3-Acetonyl-3-hydroxyoxindole functions as a potent systemic acquired resistance (SAR) inducer in plants. This compound has demonstrated the ability to enhance resistance in tobacco plants against the tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole also elevates levels of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation, and phenylalanine ammonia-lyase activity, making it a valuable tool for studying plant immune responses. -
TMV Inhibitor
TMV-IN-12 is a potent inhibitor of tobacco mosaic virus (TMV), targeting the aggregation and self-assembly of TMV capsid protein (TMV-CP) with a dissociation constant (Kd) of 0.142 μM. This compound effectively disrupts TMV particle formation, thereby preventing the infection of tobacco plants. Additionally, TMV-IN-12 exhibits antifungal properties, making it a valuable reagent for studying viral and fungal interactions in plant biology and for developing strategies to combat TMV-related diseases. -
Flaviviruse Inhibitor
Flaviviruses-IN-3 is a potent inhibitor specifically targeting flaviviruses. This compound demonstrates significant activity by reducing West Nile virus (WNV) protease activity, achieving an impressive inhibition rate of 54%. Flaviviruses-IN-3 is applicable for research into therapeutic strategies against flavivirus-related diseases and contributes to the understanding of viral protease functions. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-5 is an allosteric inhibitor targeting the NS2B/NS3 protease of Dengue Virus Serotype 2 (DENV2) and Zika Virus (ZIKV). It demonstrates effective inhibitory activity with IC50 values of 0.67 µM against ZIKV and 4.38 µM against DENV2 NS2B/NS3 proteases. This compound presents significant potential for research applications in virology, specifically in the development of antiviral therapies targeting these flavivirus proteases. -
MTase Inhibitor
NSC 288387 is a pan-flavivirus methyltransferase (MTase) inhibitor that targets the S-adenosylmethionine (SAM) binding pocket. It demonstrates significant antiviral activity, inhibiting Zika virus (ZIKV) replication with an IC50 of 0.2 μM. This compound is useful in research applications focused on flavivirus infections and the mechanisms of viral replication. -
Flaviviruses Inhibitor
Flaviviruses-IN-2 is a potent inhibitor targeting flavivirus proteases, particularly effective against the West Nile virus (WNV). This compound significantly reduces WNV protease activity, achieving an inhibition level of 56%. Flaviviruses-IN-2 is primarily utilized in research applications focused on understanding flaviviral pathogenesis and developing antiviral therapeutics. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-4 is an allosteric inhibitor targeting the NS2B/NS3 protease of dengue virus serotype 2 (DENV2) and Zika virus (ZIKV). It demonstrates IC50 values of 0.69 µM for DENV2 and 1.04 µM for ZIKV proteases, highlighting its potent enzymatic inhibition. This compound serves as a valuable tool in antiviral research, particularly for elucidating mechanisms of viral replication and developing therapeutic strategies against flavivirus infections. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-6 is an allosteric inhibitor targeting the NS2B/NS3 protease of Dengue virus (DENV) and Zika virus (ZIKV). It exhibits IC50 values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively. This compound is valuable for research applications focused on developing antiviral therapies and understanding the enzymatic mechanisms of flavivirus proteases. -
HIV-1 Protease Inhibitor
(Rac)-PD 135390 is a potent HIV-1 protease inhibitor, exhibiting an IC50 of 2 nM. This dipeptide is instrumental in antiviral research, providing insights into HIV-1 protease activity and potential therapeutic interventions. Its efficacy in inhibiting viral replication makes it a valuable tool for studying HIV pathogenesis and drug resistance. -
DENV2 Inhibitor
YKL-04-085 is a potent inhibitor of dengue virus serotype 2 (DENV2) translation, demonstrating an IC90 of 0.555 μM. This compound specifically targets viral translation mechanisms, making it a valuable tool for research on DENV2 pathogenesis and antiviral drug development. Additionally, YKL-04-085 shows no kinase activity, allowing for more targeted investigations into its antiviral efficacy. -
Fungicide
Bromuconazole is a triazole fungicide that targets fungal cells and demonstrates effective crop protection. In addition to its primary function, it exhibits cytotoxic properties against various cancer cell lines by inducing G0/G1 cell cycle arrest, inhibiting DNA synthesis, and triggering apoptosis through the activation of caspase-3. Bromuconazole also enhances reactive oxygen species production, influences mitochondrial function, and disrupts MAPK signaling pathways, thereby impairing the stress response in human trophoblast and endometrial cells. This reagent is suitable for research applications in glioma, colon cancer, reproductive health, and cardiac dysfunction studies. -
Antiplasmodial Agent
19,20-Epoxycytochalasin C is a cytochalasin derivative derived from the fungal species Nemania sp. This compound demonstrates significant in vitro antiplasmodial activity, making it a valuable tool for malaria research. Additionally, it exhibits phytotoxic properties, further expanding its potential applications in studying plant interactions and responses. -
Antiparasitic Agent
Sporogen AO-1 is a fungal metabolite derived from Aspergillus oryzae, functioning as an antiparasitic agent. It exhibits potent antimalarial activity, specifically targeting Plasmodium falciparum, with an IC50 value of 1.53 μM. Additionally, Sporogen AO-1 demonstrates certain levels of cytotoxicity, making it a valuable compound for research in parasitic diseases and potential therapeutic applications. -
Nematode Growth Inhibitor
5-(4-Methoxyphenyl)oxazole is a nematode growth inhibitor that targets Caenorhabditis elegans, effectively interfering with hatching and growth processes. This compound, derived from fungal culture broth, exhibits potential in studying nematode biology and assessing the efficacy of nematicidal agents. Its application in research provides valuable insights into nematode management and development. -
Antimalarial Agent
Asperaculane B is a fungal metabolite that targets Plasmodium falciparum, exhibiting a significant antimalarial activity with an IC50 of 7.89 µM. This compound effectively inhibits the development of asexual stages of P. falciparum, showing an IC50 of 3 µM, while demonstrating low cytotoxicity to human cells. Asperaculane B serves as a valuable resource for research into malaria therapies and the mechanisms of Plasmodium transmission. -
FREP1 Inhibitor
P-orlandin is a specific inhibitor of FREP1, a protein that mediates the binding of Plasmodium gametocytes and ookinetes. This fungal metabolite demonstrates potent activity in blocking Plasmodium falciparum infections in mosquito vectors, making it a valuable tool for research in malaria transmission and vector control studies. Its unique mode of action offers insights into potential strategies for disrupting the lifecycle of malaria parasites. -
Antimalarial Drug
Chevalone C is a meroterpenoid fungal metabolite that exhibits potent antimalarial activity, demonstrating an IC50 value of 25.00 μg/mL. In addition to its antimalarial properties, Chevalone C displays anti-proliferative effects against various cancer cell lines, including colon HCT116, liver HepG2, and melanoma A375. This compound is useful for research applications in the study of malaria and cancer therapeutics. -
Non-Antibacterial Macrolide Agent
Glasmacinal is a non-antibacterial macrolide agent that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory activity, making it a valuable tool for researchers studying inflammation-related processes. This compound can be utilized in various biological research applications, including the exploration of immune response modulation and the development of novel therapeutic strategies. -
HIV Protease Inhibitor
Palinavir is a potent inhibitor of HIV-1 and HIV-2 proteases, exhibiting an IC50 range of 0.5-30 nM. It demonstrates significant antiviral activity, making it valuable for research focused on HIV treatment strategies and drug development. Palinavir's mechanism of action targets the viral protease enzyme, disrupting the replication cycle of the virus and providing insights into HIV pathogenesis and therapeutic interventions. -
HIV-1 Protease Inhibitor
Lasinavir (CGP 61755) is a selective inhibitor of HIV-1 protease, exhibiting an IC50 value of 1 nM. This compound demonstrates significant antiviral activity against HIV-1, making it a valuable tool for studying HIV-1 infection and pathogenesis. Lasinavir is applicable in research focused on antiretroviral therapies and the mechanism of protease inhibition in viral replication. -
HIV Protease Inhibitor
L-689502 is a potent HIV protease inhibitor with an IC50 of 1 nM. This compound effectively disrupts the proteolytic activity of HIV-1 protease, thereby inhibiting viral replication. L-689502 is valuable for research into antiretroviral therapies and mechanisms of HIV resistance. -
Chitinase Inhibitor
Argifin is a potent chitinase inhibitor that demonstrates sub-nanomolar activity, targeting multiple chitinase enzymes. It exhibits impressive IC50 values of 0.025 μM for SmChiA from Serratia marcescens, 6.4 μM for SmChiB, 1.1 μM for Aspergillus fumigatus chitinase B1, and 4.5 μM for human chitotriosidase. Argifin is instrumental in studies exploring chitin metabolism and offers potential applications in antifungal research and elucidation of chitinase-related diseases. -
Antiplasmodial Agent
19,20-Epoxycytochalasin D is a cytochalasin derived from the fungal species Nemania sp. It exhibits significant in vitro antiplasmodial activity, making it a valuable compound for malaria research. Additionally, it demonstrates phytotoxic properties, indicating its potential use in studies related to plant biology and herbicide development. -
SDH Inhibitor
Succinate dehydrogenase-IN-2 is a potent inhibitor targeting succinate dehydrogenase (SDH) with an IC50 value of 1.22 mg/L. This compound demonstrates significant antifungal activity, effectively inhibiting a range of fungal pathogens including S. sclerotiorum, V. mali, G. graminis, R. solani, and B. cinerea, with EC50 values in the range of 0.52-3.42 mg/L. It is a valuable tool for research applications focusing on fungal infections and metabolic pathways involving SDH. -
HIV-1 Capsid Inhibitor
Lenacapavir is an HIV-1 capsid inhibitor that targets the interface between capsid hexamers and CA monomers, disrupting capsid assembly and viral maturation. This compound inhibits the nuclear translocation of HIV-1 DNA and interferes with CA-mediated protein-protein interactions, resulting in reduced formation of 2-LTR circles and pre-integration proviruses. Additionally, Lenacapavir induces aberrant capsids and decreases the production of mature HIV-1. It demonstrates efficacy against various HIV-1 subtypes and clinical isolates, making it a valuable reagent for research on HIV-1 infection. -
HIV-1 RT Inhibitor
Tenofovir diphosphate disodium is a potent inhibitor of HIV-1 reverse transcriptase, with a Ki value of 1.55 μM for DNA and 0.022 μM for RNA. This compound exhibits key biological activity as an antiretroviral agent, making it a valuable tool for the study of HIV and AIDS. It is suitable for research applications focused on understanding viral replication and developing therapeutic strategies against HIV infection. -
HIV-1 TAT Peptide
TAT (YGRKKRRQRRR) is a cell-penetrating peptide derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1). It enhances the solubility and yield of heterologous proteins, making it a valuable tool in research applications related to protein expression and purification. TAT's ability to facilitate cellular uptake has made it a useful reagent in studies exploring intracellular delivery mechanisms and molecular therapeutics. -
HIV-1 Inhibitor
PYR01 is a non-nucleoside reverse transcriptase inhibitor that targets HIV-1 by activating the death of infected cells. It exhibits significant antiviral activity, demonstrating IC50 values of 27.5 nM and 39.7 nM for cytotoxic and antiviral effects, respectively. By promoting HIV-1 Gag-Pol dimerization and intracellular activation of HIV-1 protease, PYR01 induces selective cytotoxicity in HIV-1-infected cells. This compound is valuable for research focused on HIV biology and therapeutic strategies. -
HIV-1 Inhibitor
PF-3450074 is a specific inhibitor of the HIV-1 capsid protein (CA), exhibiting broad-spectrum antiviral activity against various HIV isolates with submicromolar potency (EC50=8-640 nM). This compound functions at an early stage of the HIV-1 life cycle, impeding viral replication by competing with the binding of nuclear host factors CPSF6 and NUP153. Additionally, PF-3450074 disrupts key processes such as uncoating, assembly, and reverse transcription, making it a valuable tool for HIV research. -
CD4-Targeted HIV Inhibitor
Cyclotriazadisulfonamide (CADA) is a selective inhibitor of HIV entry that targets CD4. It functions by inhibiting the co-translational translocation of human CD4 into the endoplasmic reticulum lumen in a signal peptide-dependent manner. In addition, CADA acts as a Sec61 translocon inhibitor, making it a valuable tool for studying HIV pathogenesis and potential therapeutic strategies against HIV infection. -
HIV-1 Inhibitor
Glycolithocholic acid 3-sulfate is a cholic acid derivative that serves as an effective HIV-1 inhibitor. It demonstrates the ability to inhibit the replication of HIV-1 in vitro, making it a valuable tool for studying HIV infection. Additionally, Glycolithocholic acid 3-sulfate may have relevance in research related to gallbladder disease. -
V-ATPase/HIV-1 Inhibitor
Diphyllin is a potent inhibitor of vacuolar H+-ATPase (V-ATPase) with an IC50 of 17 nM, and also acts as an HIV-1 inhibitor with an IC50 of 0.38 μM. This compound effectively disrupts the acidification of osteoclast lysosomes, leading to significant inhibition of osteoclast-mediated bone resorption while leaving osteoblastic bone formation unaffected. Diphyllin is valuable for investigating bone metabolism-related diseases and exploring therapeutic avenues for conditions characterized by excessive bone resorption. -
HIV Inhibitor
Censavudine is a nucleoside reverse transcriptase inhibitor that exhibits potent antiviral activity against HIV. With EC50 values ranging from 30 nM to 81 nM for HIV-2 and 450 nM to 890 nM for HIV-1, this compound is effective in disrupting viral replication. Additionally, Censavudine possesses a reactive alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a versatile tool for click chemistry applications in drug development and molecular biology research. -
HIV gag mRNA Antagonist
Trecovirsen is an antiviral agent that targets HIV gag mRNA by hybridizing with its complementary sequence at the initiation site. This interaction leads to the induction of a reversible, dose-dependent prolongation of activated partial thromboplastin time due to its polyanionic properties. Trecovirsen is applicable for research on HIV infection, providing insights into the mechanisms of viral replication and potential therapeutic strategies. -
HIV/NRTTI Inhibitor
MK-8527 is an orally active inhibitor of HIV that functions as a nucleoside reverse transcriptase translocation inhibitor (NRTTI). This compound exhibits antiviral activity by impeding reverse transcriptase, an essential enzyme for viral replication. MK-8527 is primarily utilized in research focused on the development of HIV therapeutic strategies and studying mechanisms of resistance in retroviral infections. -
HIV Inhibitor
2',3'-Dideoxyadenosine is an inhibitor of HIV replication that functions by incorporating into viral DNA, thereby terminating chain elongation. This compound exhibits significant antiretroviral activity and is utilized in research to understand mechanisms of HIV infection and the development of therapeutic strategies against the virus. Its efficacy makes it a valuable tool in antiviral studies and drug development pipelines focused on HIV.
