Antifungal Agent 22 (compound D16) is an orally active antifungal agent targeting cryptococcal meningitis, exhibiting a potent IC50 of 0.5 μg/mL. This compound effectively penetrates the blood-brain barrier and exerts its antifungal activity by compromising the integrity of fungal cell membranes in Cryptococcus neoformans H99. Antifungal Agent 22 demonstrates selective anti-Cryptococcus efficacy, characterized by good metabolic stability and low cytotoxicity, making it a promising candidate for therapeutic applications in fungal infections.
Antifungal Agent 22 (compound D16) is an orally active antifungal agent targeting cryptococcal meningitis, exhibiting a potent IC50 of 0.5 μg/mL. This compound effectively penetrates the blood-brain barrier and exerts its antifungal activity by compromising the integrity of fungal cell membranes in Cryptococcus neoformans H99. Antifungal Agent 22 demonstrates selective anti-Cryptococcus efficacy, characterized by good metabolic stability and low cytotoxicity, making it a promising candidate for therapeutic applications in fungal infections.
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