Antifungal agent 92 is a potent antifungal compound that primarily targets mitochondrial function in Sclerotinia sclerotiorum, exhibiting an EC50 of 4.4 μM. This agent disrupts mitochondrial morphology, reduces mitochondrial membrane potential, and induces the accumulation of reactive oxygen species (ROS). Additionally, antifungal agent 92 serves as a moderate inhibitor of mitochondrial complexes II and III, making it a valuable tool for research into fungal pathogenesis and mitochondrial dysfunction.
Antifungal agent 92 is a potent antifungal compound that primarily targets mitochondrial function in Sclerotinia sclerotiorum, exhibiting an EC50 of 4.4 μM. This agent disrupts mitochondrial morphology, reduces mitochondrial membrane potential, and induces the accumulation of reactive oxygen species (ROS). Additionally, antifungal agent 92 serves as a moderate inhibitor of mitochondrial complexes II and III, making it a valuable tool for research into fungal pathogenesis and mitochondrial dysfunction.
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