Antifungal agent 30 (compound A18) is a potent antifungal compound that targets cytochrome P450 51 (CYP51). It demonstrates significant antifungal activity against Candida albicans and Aspergillus fumigatus, with minimum inhibitory concentrations (MIC) of 0.03 and 0.5 μg/mL, respectively. This agent is particularly effective against fluconazole-resistant strains, making it a valuable tool for research in antifungal drug development and resistance mechanisms. The activity of Antifungal agent 30 is primarily attributed to its hydrogen and coordination bond interactions with CYP51.
Antifungal agent 30 (compound A18) is a potent antifungal compound that targets cytochrome P450 51 (CYP51). It demonstrates significant antifungal activity against Candida albicans and Aspergillus fumigatus, with minimum inhibitory concentrations (MIC) of 0.03 and 0.5 μg/mL, respectively. This agent is particularly effective against fluconazole-resistant strains, making it a valuable tool for research in antifungal drug development and resistance mechanisms. The activity of Antifungal agent 30 is primarily attributed to its hydrogen and coordination bond interactions with CYP51.
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