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Catalog No.
Product Name
Application
Product Information
Citations
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Fungal Inhibitor
Apigeninidin chloride is a 3-deoxyanthocyanidin that serves as a potent fungal growth inhibitor. Its unique structure imparts bioactive properties, making it useful as a red biocolorant in various applications. This compound is valuable for studying fungal biology and exploring potential antifungal strategies in research settings. -
1,3-β-glucan Synthase Inhibitor
Arborcandin E is a potent inhibitor of 1,3-β-glucan synthase, functioning as an effective antifungal antibiotic. It demonstrates remarkable inhibitory activity with IC50 values of 0.1 μg/mL for Candida albicans and 0.012 μg/mL for Aspergillus fumigatus. Arborcandin E also shows a minimum inhibitory concentration (MIC) range of 0.5-2 μg/mL against various Candida species, making it a valuable tool for studying fungal infections and potential therapeutic applications. -
Fungal Inhibitor
Isohemigossylic acid lactone 2-methyl ether is a sesquiterpene lactone that acts as a fungal inhibitor, specifically targeting Verticillium dahliae. It demonstrates significant antifungal activity, inhibiting conidial growth with an ED50 of 7.8 μg/mL. Sourced from the roots of Bombax malbaricum, this compound is particularly useful for research applications focused on Verticillium dahliae infections and related fungal pathogenicity studies. -
1,3-β-glucan Synthase Inhibitor
Arborcandin B is a potent inhibitor of 1,3-β-glucan synthase, functioning as an antifungal agent. It demonstrates notable biological activity with IC50 values of 0.30 μg/mL against Candida albicans and 0.025 μg/mL against Aspergillus fumigatus. Arborcandin B also reveals a minimum inhibitory concentration (MIC) of 2-4 μg/mL against various species within the genus Candida, making it a valuable tool for research in antifungal mechanisms and therapies. -
Pdr5p Inhibitor
Norbatzelladine L is a selective inhibitor of the Pdr5p transporter, demonstrating significant inhibition of its catalytic and functional activities. With an IC50 of 3.8 µM, Norbatzelladine L effectively suppresses Pdr5p ATPase activity. This compound exhibits a broad spectrum of biological activities, including antifungal, antiparasitic, antiviral, antibacterial, and antitumoral effects, making it a valuable tool for diverse research applications in microbiology and cancer studies. -
Fungal Inhibitor
Hexamide is a potent fungal inhibitor primarily targeting Trichophyton species. Its efficacy makes it a valuable compound for studying fungal infections and evaluating antifungal therapies. This reagent can be utilized in various research applications involving mycology and the development of antifungal agents. -
Fungal Inhibitor
Aleurodiscal is a fungal inhibitor derived from Aleurodiscus mirabilis. It demonstrates significant antifungal activity, making it a valuable tool in the study of fungal infections. This compound can be utilized in research applications focused on understanding fungal pathogenesis and developing antifungal therapies. -
Fungal Inhibitor
Stilbamidine is a diamidine compound that targets fungal infections by inhibiting fungal growth. Primarily utilized in its crystalline isethionate salt form, this reagent is effective against a range of fungi, making it valuable for research applications involving fungal pathology and treatment mechanisms. Its biochemical properties support studies focused on antifungal activity and resistance mechanisms in various fungal species. -
SDH Inhibitor
SDH-IN-25 is a selective inhibitor of succinate dehydrogenase (SDH), with an IC50 value of 4.82 mg/L. This compound displays significant antifungal activity by disrupting respiratory metabolism through its binding to complex II, consequently inducing hyphal morphology changes, generating reactive oxygen species (ROS), and affecting mitochondrial membrane potential (MMP) in fungal mycelia. SDH-IN-25 is suitable for research applications focused on agricultural disease management and the development of novel antifungal strategies. -
Fungal Inhibitor
Fungicide5 is a potent fungal inhibitor that specifically targets succinate dehydrogenase, exhibiting an inhibitory constant (Ki) of 0.095 μM. This compound is designed for research applications in evaluating antifungal properties and exploring metabolic pathways in fungi. Its selective action makes it a valuable tool for studying fungal biology and developing antifungal strategies. -
14α-Demethylase Inhibitor
14α-Demethylase-IN-1 is a selective inhibitor of 14α-demethylase, primarily targeting fungal biosynthesis pathways. This compound demonstrates significant antifungal activity, exhibiting MIC50 values of 2.47 μM against C. albicans, 1.23 μM against C. parapsilosis, and 19.70 μM against both C. krusei and C. glabrata over a 48-hour period. 14α-Demethylase-IN-1 is valuable for research focused on antifungal resistance mechanisms and the development of novel antifungal therapies. -
Pah Inhibitor
Phosphatase-IN-1 is a phosphatidate phosphatase (Pah) inhibitor that selectively targets MoPah1 with an affinity constant of 19.8 μM. This compound demonstrates significant antifungal activity, effectively inhibiting the growth of various plant pathogens. Importantly, Phosphatase-IN-1 exhibits low toxicity towards rice seedlings and wheat heads, making it a valuable tool for research in plant pathology and agricultural applications. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 13 is a non-competitive inhibitor specifically targeting chitin synthase, demonstrating an IC50 value of 106.7 μM. This compound exhibits broad-spectrum antifungal activity, making it a valuable tool for research in fungal biology and the development of antifungal therapies. Its mechanism of action can provide insights into chitin biosynthesis and contribute to the understanding of fungal cell wall integrity. -
Fungal Inhibitor
Bac2A TFA is an antimicrobial peptide that acts as a potent inhibitor of fungal pathogens. This linear variant of bactenecin exhibits significant antifungal activity, making it suitable for research applications focused on fungal infections and immunomodulation studies. Its unique properties offer potential insights into host-pathogen interactions and the development of novel therapeutic strategies against fungal diseases. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 5 specifically targets chitin synthase, demonstrating an IC50 value of 0.14 mM. This compound exhibits broad-spectrum antifungal activity in vitro, effectively inhibiting the growth of Candida albicans, Aspergillus flavus, Aspergillus fumigatus, and Cryptococcus neoformans. Chitin Synthase Inhibitor 5 is valuable for research focused on fungal pathogenesis and potential therapeutic strategies against fungal infections. -
Fungal Inhibitor
Deoxyviolacein is a bacterial metabolite that acts as a potent fungal inhibitor. It demonstrates significant antifungal activity against Rhizoctonia solani at a concentration of 2 mg/mL. Additionally, Deoxyviolacein exhibits antibacterial properties against Gram-positive bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Bacillus megaterium, with effective inhibition observed at 125 μg/mL. This compound has potential applications in cancer research, particularly in inhibiting the proliferation of hepatocellular carcinoma cells at concentrations ranging from 0.1 to 1 μM. -
Fungal Inhibitor
Benzyl 2-hydroxy-6-methoxybenzoate acts as a potent fungal inhibitor, demonstrating significant antifungal activity with an IC50 of 25–26 μg/mL against various fungal strains. This compound is valuable in research focused on antifungal drug development and investigating fungal resistance mechanisms. Its efficacy makes it a promising candidate for further exploration in therapeutic applications against fungal infections. -
Fungal Inhibitor
Antifungal agent 67 is an imidazole compound that targets fungal pathogens, demonstrating significant efficacy against Candida species. This agent exhibits a CC50 value of 33.6 μM in healthy neonatal rat cardiomyoblasts, indicating its potential impact on cellular viability. Antifungal agent 67 is suitable for research applications concerning antifungal mechanisms and the development of therapeutic strategies against fungal infections. -
1,3-β-glucan Synthase Inhibitor
Arborcandin C is a potent inhibitor of 1,3-β-glucan synthase, functioning as an antifungal antibiotic. It demonstrates strong biological activity with IC50 values of 0.15 μg/mL against Candida albicans and 0.015 μg/mL against Aspergillus fumigatus. Furthermore, Arborcandin C exhibits a minimum inhibitory concentration (MIC) of 1-2 μg/mL against various Candida species, making it valuable for research into antifungal mechanisms and treatments. -
Conidia Inhibitor
Carviolin is a conidia inhibitor derived from the mycelia of the ascomycete Neobulgaria pura. It effectively inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on hydrophobic surfaces. While exhibiting moderate cytotoxicity, Carviolin does not possess antifungal, antibacterial, or phytotoxic activities, making it a useful tool for studies focused on fungal germination and pathogenesis. -
Fungal Inhibitor
Ophiobolin B is a sesterterpene metabolite derived from Helminthosporium oryzae, primarily functioning as a fungal inhibitor. This compound effectively inhibits proton extrusion in maize coleoptiles, while also blocking fusicoccin-promoted proton extrusion, potassium uptake, and subsequent cell enlargement. With minimal inhibitory concentration (MIC) values ranging from 25 to 50 μg/mL, Ophiobolin B demonstrates significant antifungal activity against various zygomycetes, making it valuable for research in plant-fungal interactions and cellular physiology. -
Antifungal Agent/C-4 Sterol Methyl Oxidase Inhibitor
PF-1163A is an antifungal agent that functions as a C-4 sterol methyl oxidase inhibitor, effectively disrupting ergosterol synthesis with an IC50 of 12 ng/mL. This compound demonstrates notable antifungal activity, characterized by a minimum inhibitory concentration (MIC) of 12.5 µg/mL. PF-1163A is valuable for research applications focused on fungal infections and the mechanistic understanding of ergosterol biosynthesis. -
Chitin Deacetylase Inhibitor
AnCDA-IN-1 is a selective inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal properties. It exhibits an IC50 value of 4.24 μM against AnCDA from Aspergillus nidulans and shows a minimum inhibitory concentration (MIC) of 260 μg/mL against various food spoilage and plant pathogenic fungi, with a minimum fungicidal concentration (MFC) of 520 μg/mL. This compound is valuable for research in the antifungal domain, particularly in understanding CDA's role in fungal cell wall integrity and potential therapeutic applications. -
Hyphal Formation Inhibitor
2-Dodecanol is an effective hyphal formation inhibitor with targeted activity against Candida albicans. By inhibiting SIR2 expression, it disrupts the morphological transition essential for pathogenicity. This compound is valuable for researchers studying fungal biology and the mechanisms of infection, as well as for developing potential antifungal strategies. -
Glutamate Transport Inhibitor
Avenaciolide is a bis-γ-lactone derived from Aspergillus avenaceus that acts as a specific inhibitor of glutamate transport. This compound demonstrates antifungal and antibacterial properties while also interfering with the stimulatory effect of ADP on glutamate oxidation in rat liver mitochondria. Avenaciolide's unique mechanism makes it valuable for studying metabolic processes and the regulation of glutamate transport in cellular and mitochondrial contexts. -
Succinate Dehydrogenase Inhibitor
SDH-IN-3 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 of 7.2 μg/mL. This compound exhibits significant antifungal activity against Nigrospora oryzae, with an EC50 of 1.9 μg/mL. SDH-IN-3 is suitable for research applications focused on anti-infection studies and the modulation of metabolic pathways in fungal pathogens. -
SARS CoV-2 3CLpro Inhibitor
SARS-CoV-2 3CLpro-IN-4 is a potent inhibitor of the SARS-CoV-2 3CL protease, a critical enzyme for viral replication. This compound exhibits significant antiviral activity, making it relevant for research in COVID-19 therapeutics. Its broad-spectrum impact also extends to antibacterial and antifungal activities, aiding investigations into multi-faceted infectious disease mechanisms. -
Ras Inhibitor
Antifungal agent 46 is a potent Ras inhibitor that targets protein farnesyltransferase, effectively disrupting Ras signaling pathways. This compound demonstrates significant antifungal activity and holds potential for research applications focused on understanding Ras-related mechanisms in fungal infections. Studies may explore its utility in elucidating the role of Ras in cellular signaling and its implications in therapeutic developments. -
Fungal Inhibitor
Antibacterial agent 188 is a potent fungal inhibitor that targets dermatophyte activity. This compound demonstrates significant antifungal properties, making it suitable for research applications focused on fungal infections and dermatological studies. Its mechanism of action involves disrupting fungal cell processes, thereby inhibiting growth and proliferation. -
Succinate Dehydrogenase Inhibitor
Harzianopyridone is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 80 nM. Isolated from the fungus Trichoderma harzianum, this compound demonstrates significant antifungal, antibacterial, and herbicidal properties. Harzianopyridone is valuable for research applications exploring metabolic modulation and the study of fungal and bacterial pathways. -
Gamma-Glutamyl Transferase Inhibitor
Gamma-Glutamyl Transferase-IN-1 is a potent inhibitor of gamma-glutamyl transferase, specifically designed to disrupt its enzymatic function. This β-carboline 1-hydrazide compound exhibits significant antifungal and antibacterial activities by promoting the accumulation of reactive oxygen species, leading to cell membrane disruption and alterations in histone acetylation. It serves as a valuable tool for research investigating the roles of gamma-glutamyl transferase in various biological processes and disease states. -
Antifungal Agent/LOX-1 Inhibitor
Sclerotiorin is a reversible uncompetitive inhibitor of soybean lipoxygenase-1 (LOX-1), with an IC50 value of 4.2 μM. This compound exhibits significant antioxidant activity by scavenging free radicals (ED50: 0.12 μM) and inhibiting nonenzymatic lipid peroxidation. Additionally, Sclerotiorin demonstrates antifungal properties and the ability to inhibit platelet aggregation. It can be isolated from the fermented broth of Penicillium frequentans, making it a valuable reagent for research in antifungal mechanisms and oxidative stress studies. -
SDH Inhibitor
SDH-IN-18 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 8.70 mg/L. This compound demonstrates significant antifungal activity, disrupting the morphology and reproduction of fungi. It is particularly effective against Rhizoctonia solani and Sclerotinia sclerotiorum, with EC50 values of 0.48 mg/L and 1.4 mg/L, respectively. SDH-IN-18 can be utilized in research studying fungal pathology and SDH-related metabolic pathways. -
Pdr1-KIX Inhibitor
Antifungal agent 72 is a selective Pdr1-KIX inhibitor that effectively suppresses efflux pump function and down-regulates resistance-related genes through disruption of the Pdr1-KIX interaction, with a Ki value of 11.7 μM. This compound demonstrates significant antifungal activity against Fluconazole-resistant strains, exhibiting a minimum inhibitory concentration (MIC) of 63 ng/mL and showing synergistic effects when used in combination with Fluconazole. Antifungal agent 72 is particularly valuable for research focused on C. glabrata infections and the development of novel antifungal strategies. -
Fungal Inhibitor
Alteconazole is an azole derivative that acts as a potent antifungal agent. It exerts its action by inhibiting the enzyme lanosterol demethylase, which is essential for ergosterol synthesis in fungal membranes. This compound is valuable for research in the study of fungal pathogens and the development of antifungal therapies. Its mechanism of action makes it suitable for investigations into cellular responses to fungal infections and resistance mechanisms. -
PLA2 Inhibitor
Plipastatin B1 is a lipopeptide antibiotic that acts as an inhibitor of phospholipase A2 (PLA2). This compound exhibits antifungal activity, making it a valuable tool in investigating fungal pathogenesis and potential therapeutic interventions. It is applicable in research focusing on the modulation of PLA2-related pathways and the development of antifungal drugs. -
SDH Inhibitor
Succinate dehydrogenase-IN-1 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.94 μM and a KD of 22.4 μM. This compound demonstrates significant antifungal activity against various pathogens, including Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea, with EC50 values of 0.04 μM, 1.13 μM, 1.61 μM, and 1.21 μM, respectively. Succinate dehydrogenase-IN-1 can be utilized in studies focusing on fungal infections and metabolic pathways involving SDH inhibition. -
Fungal Inhibitor
Antifungal Agent 120 is a potent fungal inhibitor targeting S. dermatitidis, a pathogenic fungus associated with skin infections. This reagent demonstrates significant antifungal activity and serves as a valuable tool for researchers studying fungal biology and therapeutic interventions. Further investigation may reveal efficacy against additional fungal species, expanding its potential applications in mycology research. -
SDH Inhibitor
Y12196 is a potent succinate dehydrogenase inhibitor (SDHI) that demonstrates strong fungicidal activity against Fusarium graminearum. This compound targets the mitochondrial metabolic pathway, disrupting energy production in fungal cells. Y12196 is valuable for investigating the role of SDH in fungal metabolism and can be utilized in studies aimed at controlling plant pathogens. -
1,3-β-glucan Synthase Inhibitor
Arborcandin F is a potent inhibitor of 1,3-β-glucan synthase, acting as an effective antifungal antibiotic. It displays IC50 values of 0.012 μg/mL against Candida albicans and Aspergillus fumigatus, demonstrating significant antifungal activity. Arborcandin F also exhibits a minimum inhibitory concentration (MIC) of 2-4 μg/mL against the genus Candida, making it a valuable reagent for research into fungal infections and therapeutic applications. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 7 is a potent inhibitor of chitin synthase (CHS) with an IC50 value of 0.37 mM. This compound demonstrates broad-spectrum antifungal activity, particularly against drug-resistant fungi. It is valuable for research applications focused on fungal infections and understanding the role of chitin biosynthesis in fungal pathogens. -
Fungal Inhibitor
Antifungal Agent 14, a potent fungal inhibitor, demonstrates broad-spectrum activity against various fungal strains with impressive minimum inhibitory concentration values. This compound is designed for use in research applications focusing on antifungal treatment and the investigation of fungal pathogenesis, making it a valuable tool for studying fungal infections and developing therapeutic strategies. -
Bacterial/Fungal Inhibitor
Pyruvic acid semicarbazone is a bacterial and fungal inhibitor. This compound demonstrates significant biological activity against various microbial strains, making it a valuable tool for investigating anti-infective agents. Additionally, pyruvic acid semicarbazone has potential applications in cancer research and plant growth regulation studies. -
CHS Inhibitor
Chitin Synthase Inhibitor 11 is a potent inhibitor of chitin synthase, demonstrating significant inhibitory activity with an IC50 value of 0.10 mM. This compound exhibits broad-spectrum antifungal properties in vitro, making it a valuable tool for investigating invasive fungal infections (IFIs). Its ability to disrupt chitin biosynthesis positions it as a promising candidate for enhancing understanding of antifungal mechanisms and therapies. -
CHS Inhibitor
Chitin Synthase Inhibitor 12 targets chitin synthase, demonstrating potent inhibitory activity with an IC50 of 0.16 mM. This compound serves as a broad-spectrum antifungal agent, exhibiting significant efficacy against drug-resistant strains, including Candida albicans and Cryptococcus neoformans. Chitin Synthase Inhibitor 12 is suitable for research applications involving invasive fungal infections (IFIs). -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 14 is a selective inhibitor of chitin synthase (CHS), which plays a critical role in the synthesis of chitin, a key component of fungal cell walls. This compound exhibits significant antifungal activity and demonstrates effectiveness against drug-resistant fungal strains. It is valuable for research applications focused on fungal biology, drug resistance mechanisms, and the development of new antifungal therapies. -
Fas1 Inhibitor
(Rac)-NPD6433 is a Fas1 inhibitor targeting the enoyl reductase domain of fatty acid synthase 1. As a triazenyl indole, it demonstrates broad-spectrum antifungal activity against various screening fungal strains. By covalently inhibiting flavin mononucleotide-dependent NADPH-oxidation activity, (Rac)-NPD6433 effectively disrupts essential fatty acid biosynthesis, making it a valuable tool for research in fungal metabolism and potential therapeutic applications. -
Fungal Inhibitor
Antifungal agent 15 is a potent fungal inhibitor that exhibits significant biological activity, demonstrated by EC50 values of 0.52 μg/mL against Sclerotinia sclerotiorum and 0.50 μg/mL against Botrytis cinerea. This compound is suitable for research applications aimed at understanding fungal pathogenesis and developing antifungal therapies. Its high efficacy makes it a valuable tool for investigating fungal resistance mechanisms and optimizing treatment strategies in agricultural and clinical settings. -
CaMdr1p Inhibitor
CaMdr1p-IN-1 is a specific inhibitor of the major facilitator superfamily transporter CaMdr1p. This compound demonstrates significant chemosensitizing effects, particularly in enhancing the efficacy of Fluconazole against CaMdr1p-overexpressing Candida albicans, achieving a minimum inhibitory concentration (MIC) of 10 μM. CaMdr1p-IN-1 is valuable for research focused on antifungal drug resistance mechanisms and the development of combination therapies against fungal pathogens. -
Fungal Inhibitor
Neocnidilide is an alkylphthalide that acts as a fungal inhibitor, specifically targeting mycotoxin-producing fungi to suppress their growth. Additionally, it exhibits larvicidal properties against Drosophila melanogaster, with a lethal concentration (LC50) of 9.9 μmol/mL. This compound is relevant for research applications focused on mycology and pest control in agricultural settings.
