Catalog No.
Product Name
Application
Product Information
Citations
-
Insecticide
Insecticidal Agent 5 (compound 8) is a potent acetylcholinesterase (AChE) inhibitor designed for use as an insecticide. It exhibits significant biological activity with an LD50 of 27.65 ppm against the cotton leafworm, Spodoptera littoralis. This compound serves as an essential tool in research focused on pest control and insect physiology. -
BChE Inhibitor
BChE-IN-5 is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 of 2.8 nM, demonstrating greater potency against human BChE compared to human acetylcholinesterase (hAChE). This compound is valuable for research focused on neurodegenerative disorders, particularly Alzheimer's disease, by modulating cholinergic signaling pathways. Its specificity and efficacy make BChE-IN-5 a significant tool in elucidating the role of BChE in cognitive decline and related pathologies. -
Compound Intermediate
6,9-Dichloro-1,2,3,4-tetrahydroacridine serves as an important intermediate in the synthesis of acetylcholinesterase (AChE) inhibitors. These inhibitors are relevant in the investigation of Alzheimer's disease, facilitating research on therapeutic strategies aimed at enhancing cholinergic transmission. This compound is essential for studying AChE's role in neurodegeneration and cognitive decline. -
AChE Inhibitor
Stacofylline is a potent inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 range of 5-50 nM. This xanthine derivative demonstrates significant anti-amnesic and promnesic properties, making it a valuable compound for research involving cognitive enhancement and memory-related studies. Its ability to modulate cholinergic neurotransmission highlights its potential applications in neuropharmacology and the investigation of Alzheimer's disease and other memory disorders. -
AChE Inhibitor
8-Hydroxydihydrochelerythrine is a selective and competitive inhibitor of acetylcholinesterase (AChE) with an IC50 of 0.61 μM. Derived from the roots of Zanthoxylum nitidum, this benzophenanthridine alkaloid enhances acetylcholine levels in cholinergic synapses, thereby facilitating improved cholinergic neurotransmission. Its unique mechanism makes 8-Hydroxydihydrochelerythrine valuable for research into neurodegenerative disorders, particularly Alzheimer's disease and related dementias. -
AChE/BChE Inhibitor
AChE/BChE-IN-2 is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 0.96 ± 0.14 µM for AChE and 1.23 ± 0.23 µM for BChE. This compound is valuable for research into Alzheimer's disease and other neurodegenerative disorders, facilitating studies on cholinergic signaling and enzyme activity modulation. Its efficacy in inhibiting cholinesterases makes it a significant tool for understanding the biochemical pathways involved in cognitive decline. -
AChE/BChE Inhibitor
AChE/BChE-IN-6 is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 0.809 µM for AChE and 2.248 µM for BChE, with limited activity against hMAO-B. This compound effectively penetrates the blood-brain barrier, making it a valuable tool for research focused on Alzheimer's disease. Its ability to inhibit cholinesterases suggests potential applications in studies aiming to understand and develop treatments for neurodegenerative conditions characterized by cholinergic dysfunction. -
AChE Inhibitor
AChE-IN-24 is a potent inhibitor of acetylcholinesterase (AChE), demonstrating remarkable ability to penetrate the blood-brain barrier. It exhibits strong inhibitory activity against human AChE, with an IC50 value of 0.053 μM. This compound is valuable for research in Alzheimer's disease, facilitating studies aimed at understanding the enzymatic mechanisms involved in neurodegeneration. -
AChE Inhibitor
Artanin is a coumarin derivative that functions as an acetylcholinesterase (AChE) inhibitor. It demonstrates significant biological activities relevant to Alzheimer's disease, including the inhibition of AChE and the prevention of amyloid beta (Aβ) aggregation, with IC50 values of 51 μM, 98 μM, and 124 μM, respectively. This compound is valuable for research focusing on neurodegenerative disorders and the mechanistic exploration of Alzheimer's pathology. -
sEH/AChE Inhibitor
sEH/AChE-IN-2 is a dual inhibitor targeting soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). This compound demonstrates significant potential in mitigating neuroinflammation and addressing memory impairment. Its dual inhibitory action provides a valuable tool for investigating therapeutic strategies in Alzheimer's disease research. -
AChE/BuChE/MAO-B Inhibitor
AChE/BuChE/MAO-B-IN-1 is a potent inhibitor of human acetylcholinesterase (hAChE), butyrylcholinesterase (hBuChE), and monoamine oxidase-B (hMAO-B), with IC50 values of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. This compound also demonstrates a high affinity for σ1 and σ2 receptors, with Ki values of 42.8 nM and 191 nM, respectively. AChE/BuChE/MAO-B-IN-1 is potentially useful in research focused on Alzheimer's disease and related neurological disorders. -
eeAChE/eqBuChE Inhibitor
eeAChE/eqBuChE-IN-1 is a reversible dual inhibitor targeting both eeAChE and eqBuChE, with IC50 values of 1.3 μM and 0.81 μM, respectively. This compound demonstrates significant anti-inflammatory activity and offers neuroprotective effects, particularly in mitigating Aβ25-35-induced cytotoxicity in PC12 cells. It is suitable for research applications focused on neurodegenerative diseases and related pathways. -
AChE Inhibitor
AChE-IN-31 is a non-competitive inhibitor of acetylcholinesterase (AChE). This compound demonstrates significant potential in the exploration of Alzheimer's disease pathology by modulating cholinergic signaling. AChE-IN-31 is suitable for use in research applications aimed at understanding the mechanisms of neurodegeneration and developing therapeutic strategies for cognitive disorders. -
AChE Inhibitor
AChE-IN-71 is an acetylcholinesterase (AChE) inhibitor that plays a significant role in the modulation of neurotransmitter levels. This compound is particularly relevant for research focused on neurodegenerative disorders, including Alzheimer’s disease. By inhibiting AChE activity, AChE-IN-71 can help elucidate the mechanisms underlying cholinergic dysfunction in Alzheimer's pathology, providing valuable insights for potential therapeutic strategies. -
Antisense Oligodeoxynucleotide
Monarsen is a synthetic 20-base antisense oligodeoxynucleotide targeting the human acetylcholinesterase (AChE) gene. This compound is utilized in research related to autoimmune myasthenia gravis (MG), a neuromuscular disorder characterized by autoantibodies against the acetylcholine receptor (AChR). Monarsen's mechanism of action allows for the inhibition of AChE expression, making it a valuable tool for studying disease mechanisms and potential therapeutic interventions in MG. -
AChE/BuChE Inhibitor
Feralolide is a dihydroisocoumarin that functions as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), exhibiting IC50 values of 55 μg/mL and 52 μg/mL, respectively. This compound also demonstrates antioxidant properties, effectively inhibiting 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide may serve as a valuable tool in research focused on cognitive disorders, such as Alzheimer's disease, aiming to restore and enhance memory functions. -
Cholinesterase (ChE) Inhibitor
Echothiopate chloride is a potent, irreversible inhibitor of cholinesterase (ChE). By forming a covalent bond with the serine residue at the active site of ChE, it permanently inactivates the enzyme, necessitating de novo enzyme synthesis for restoration of activity. This long-lasting inhibition makes echothiopate chloride effective in ocular applications, particularly as a miotic agent in the management of chronic glaucoma and accommodative esotropia, with effects that can persist for over a week. -
AChE Inhibitor
Lycoramine is a dihydro-derivative of galanthamine that functions as a potent acetylcholinesterase (AChE) inhibitor. Isolated from the plant Lycoris radiata, it demonstrates significant potential in enhancing cholinergic signaling, making it a valuable reagent for research related to neurodegenerative diseases and cognitive disorders. Its inhibitory action on AChE may offer insights into therapeutic strategies for conditions such as Alzheimer's disease. -
Cholinesterase Inhibitor
AChE/BChE-IN-31 is a cholinesterase inhibitor targeting human acetylcholinesterase (hAChE) and equine butyrylcholinesterase (eqBChE). It demonstrates significant inhibitory activity against these enzymes, making it relevant for research on neurodegenerative diseases such as Alzheimer’s disease. Additionally, AChE/BChE-IN-31 exhibits antioxidant properties, with an IC50 value of 105.04 μM against DPPH, indicating its potential utility in studies related to oxidative stress. -
Cholinesterase Inhibitors; Lupane Derivative; Molecular Modeling; Triterpenoid
3β-Hydroxy-lup-20(29)-en-16-one is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting a notable selectivity for BChE with an IC50 value of 28.9 μM. This lupane derivative serves as a valuable tool in the study of cholinergic signaling pathways and triterpenoid research. Its inhibitory properties position it as a potential candidate for neurodegenerative disease research applications, particularly in disorders characterized by cholinergic dysregulation. -
AChE/BChE Inhibitor
AChE/BChE-IN-24 is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 16.38 μM and 10.44 μM, respectively. This compound functions as a neuroprotective agent by preventing the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. Its applications are particularly relevant in research related to neurodegenerative diseases and cognitive function disorders. -
AChE/BChE Inhibitor
Lakoochin C is a potent inhibitor of acetylcholinesterase (AChE) with an IC50 of 61.86 μM and butyrylcholinesterase (BChE) with an IC50 of 47.21 μM. This compound demonstrates significant biological activity in modulating cholinergic signaling, making it a valuable tool for research focused on neurodegenerative diseases such as Alzheimer's disease. Its application in studies of cholinergic dysfunction may provide insights into therapeutic strategies for memory-related disorders. -
AChE Inhibitor
AChE-IN-64 is a selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 36.9 µM. This compound is primarily utilized in research related to cognitive disorders, offering a valuable tool for the investigation of cholinergic dysfunction and its implications in conditions such as Alzheimer's disease and other neurodegenerative disorders. -
AChE Inhibitor
Quinolactacin A1 is a potent acetylcholinesterase (AChE) inhibitor derived from the solid-state fermentation of Penicillium citrinum 90648. It exhibits significant biological activity in inhibiting AChE, making it a valuable compound for studying neurodegenerative disorders, particularly Alzheimer's disease. Research applications include exploring therapeutic strategies and understanding the biochemical pathways associated with cholinergic dysfunction. -
AChE Inhibitor
Cyanofenphos is an orally active organophosphate compound that acts as an acetylcholinesterase (AChE) inhibitor, exhibiting neurotoxic properties. This reagent is associated with delayed neurotoxic effects, including ataxia and paralysis, and may present additional symptoms such as somnolence, decreased feed intake, and weight loss in avian models. Cyanofenphos demonstrates a self-antagonistic effect, whereby repeated low-dose pre-treatment can mitigate acute toxicity but exacerbate long-term neurotoxicity and decrease enzyme inhibition, with protective effects peaking 24 hours post-treatment. This compound is widely utilized in research focused on neurotoxicity and AChE inhibition pathways. -
Radioligand for Brain Imaging
TRV-7019 is a brain-penetrating radioligand that targets butyrylcholinesterase, facilitating advanced imaging techniques. This compound is instrumental for diagnostic applications related to amyloid diseases, multiple sclerosis, brain tumors, and the assessment of butyrylcholinesterase activity. Its specificity and ability to cross the blood-brain barrier make it a valuable tool for neurological research and clinical diagnostics. -
Caffeic Acid Ester Compound
2-Methyl-2-butenyl (E)-Caffeate is a caffeic acid ester compound that exhibits inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It also demonstrates significant antioxidant properties, making it a valuable reagent for studying oxidative stress. This compound is particularly relevant for research related to neurodegenerative diseases such as Alzheimer's disease. -
BChE Inhibitor
BChE-IN-9 (Azepano-11-deoxo-glycyrrhetol) is a mixed type inhibitor of butyrylcholinesterase (BChE) with a Ki value of 0.21 µM. This compound exhibits significant inhibitory activity, making it a valuable tool for studying cholinergic signaling pathways and neurodegenerative diseases where BChE is implicated. Its use in research can provide insights into therapeutic strategies for conditions such as Alzheimer's disease and other neurocognitive disorders. -
AChE Inhibitor
AChE-IN-21 is a potent and selective inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 2.66 nM. This compound demonstrates significant blood-brain barrier permeability in vitro, making it suitable for central nervous system research applications. AChE-IN-21 may be utilized in studies related to neurodegenerative diseases, such as Alzheimer's disease, by modulating cholinergic signaling pathways. -
Acetylcholinesterase Inhibitor
Quilostigmine is a potent acetylcholinesterase inhibitor with an IC50 of 148 nM in rat brain acetylcholinesterase. This orally active analogue of Physostigmine demonstrates prolonged efficacy in reducing tremors. Its mechanism of action makes it a valuable tool for research related to Alzheimer's disease and other cognitive disorders. -
BChE Inhibitor
BChE-IN-4 is a potent butyrylcholinesterase (BChE) inhibitor that effectively crosses the blood-brain barrier. This compound has demonstrated the ability to attenuate learning and memory deficits associated with cholinergic deficits in mouse models. BChE-IN-4 shows promise for research applications related to Alzheimer's disease, making it a valuable tool for investigations into cognitive dysfunction and neurotransmitter modulation. -
BChE Inhibitor
Bleformin A is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 value of 5.2 μM. Isolated from the natural source Bletilla striata, this compound demonstrates significant biological activity that is relevant to neurodegenerative disorders. Bleformin A is primarily utilized in research related to Alzheimer's disease, providing insights into cholinergic system modulation. -
Acetylcholinesterase Inhibitor, Butyrylcholinesterase Inhibitor
Melineurine is a reversible mixed-type inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 95.3 μM for AChE and 28.0 μM for BChE. This compound is instrumental in the study of neurodegenerative disorders, particularly Alzheimer's disease, due to its effects on cholinergic signaling. Melineurine serves as a valuable tool for investigating the role of cholinesterase inhibition in cognitive function and related therapeutic strategies. -
Copper Chelator
SON38 is a copper chelator that selectively binds divalent copper ions. This compound exhibits inhibitory effects on cholinesterase activity, making it a valuable tool for research into Alzheimer's disease and related neurodegenerative disorders. Its ability to modulate copper levels underscores its potential in studying copper's role in various biological processes. -
AChE Inhibitor
Fasciculin-II is a potent inhibitor of acetylcholinesterase (AChE), an enzyme critical for neurotransmitter regulation. By blocking AChE activity, Fasciculin-II enhances cholinergic transmission, making it a valuable tool for research in neurobiology and related fields. Its biological activity is particularly relevant in studies of synaptic function and neurodegenerative diseases. -
AChE/BChE/MAO-B Inhibitor
AChE/BChE/MAO-B-IN-1 is a reversible inhibitor targeting acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase B (MAO-B), exhibiting IC50 values of 7.31 μM, 0.56 μM, and 26.1 μM, respectively. This compound effectively crosses the blood-brain barrier and demonstrates neuroprotective properties while maintaining a lack of cytotoxicity. Its multifaceted inhibition profile makes it a valuable tool for research on neurodegenerative diseases and associated pathways. -
Dual MAO-AChE Inhibitor
MAO-A/B-IN-3 is a dual inhibitor targeting both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), as well as acetylcholinesterase (AChE). With IC50 values of 67 nM for MAO-A, 29 nM for MAO-B, and 1370 nM for AChE, this compound demonstrates substantial multi-target efficacy. MAO-A/B-IN-3 modifies key binding sites to enhance its inhibitory activity against MAO enzymes while reducing the impact on AChE. This reagent is particularly relevant for research focused on neurodegenerative disorders. -
Cholinesterase (ChE) Inhibitor
Dihydro Donepezil is a potent cholinesterase (ChE) inhibitor, serving as a metabolite of Donepezil. It demonstrates significant biological activity, inhibiting acetylcholinesterase with IC50 values of 8.12 nM for bovine acetylcholinesterase (bAChE) and 11.6 nM for human acetylcholinesterase (hAChE). This compound is primarily utilized in research focused on neurodegenerative disorders and cognitive enhancement, contributing to studies on Alzheimer's disease and related pathways. -
AChE Inhibitor
AChE-IN-52 is an acetylcholinesterase (AChE) inhibitor that demonstrates notable antitumor activity, particularly against breast cancer MCF-7 cells. This compound significantly disrupts amino acid metabolism and inhibits the migration of MCF-7 cells. Furthermore, AChE-IN-52 exerts its anticancer effects through the regulation of Best1 and HIST1H2BJ, making it a valuable tool for research in cancer biology and therapeutic development. -
nAChR Modulator
JNJ-1930942 is a selective positive allosteric modulator of the α(7) nicotinic acetylcholine receptor (nAChR) that effectively crosses the blood-brain barrier. This compound facilitates heightened intracellular Ca2+ levels and promotes neurotransmission at synapses in the hippocampal dentate gyrus. Additionally, JNJ-1930942 has been shown to reverse sensory gating deficits in DBA/2 mouse models, making it a valuable tool for research in neuropsychiatric disorders and synaptic physiology. -
AchE Inhibitor
1,10-Bis(pyridinium)decane is a biscationic compound that acts as an acetylcholinesterase (AchE) inhibitor, demonstrating an IC50 of 25.8 nM. This reagent is valuable for research focused on neuropharmacology and the modulation of cholinergic signaling. Its specificity for AchE makes it suitable for studies investigating cognitive function and neurodegenerative diseases. -
AChE Inhibitor
Ganstigmine hydrochloride is an orally active inhibitor of acetylcholinesterase (AChE) that enhances the release of soluble amyloid precursor protein alpha (sAPPα) from neuroblastoma cells. This compound has been shown to increase acetylcholine levels in the prefrontal cortex of rats, making it a valuable tool in the study of cholinergic signaling. Ganstigmine hydrochloride is primarily utilized in research focused on neurological disorders, particularly Alzheimer's disease, to explore its implications in cognitive function and neuroprotection. -
BChE Inhibitor
BChE-IN-13 is a potent and selective inhibitor of Butyrylcholinesterase (BChE), targeting both equine and human forms with IC50 values of 0.22 μM and 0.016 μM, respectively. This orally active compound demonstrates significant potential for enhancing memory and cognitive functions, making it a valuable tool in Alzheimer's disease research. Its specificity for BChE positions it as a promising candidate for exploring therapeutic strategies in neurodegenerative disorders. -
AChE/BChE Inhibitor
AChE/BChE-IN-3 hydrochloride is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 6.08 μM against electric eel AChE and 0.383 μM against equine serum BChE. This compound is valuable for research focused on neurodegenerative diseases and cholinergic dysfunction, providing insights into the modulation of cholinergic signaling pathways. Its potent inhibitory effects make it a useful tool for studying enzyme kinetics and drug discovery related to cognitive decline. -
AchE Inhibitor
Icopezil is a selective inhibitor of acetylcholinesterase (AchE), a key enzyme involved in the hydrolysis of acetylcholine. Its ability to enhance cholinergic transmission makes it a valuable compound for research in Alzheimer's disease and other cognitive disorders. By increasing acetylcholine levels in the synaptic cleft, Icopezil offers potential insights into therapeutic strategies targeting cholinergic deficits in neurodegenerative conditions. -
Antispasmodic Agent
Pitofenone is a potent spasmolytic compound that primarily functions as an antispasmodic agent. It effectively inhibits acetylcholinesterase (AChE) activity in bovine erythrocytes and electric eel, exhibiting inhibition constants (Kis) of 36 μM and 45 μM, respectively. This compound is widely used in research applications focusing on muscle spasm relief and neuropharmacology. -
Cholinesterase (ChE) Inhibitor
(+)-Balanophonin is a phenolic compound that functions as an inhibitor of cholinesterase (ChE). It exhibits significant biological activities, including antioxidant, anti-inflammatory, anticancer, and antineurodegenerative effects. This compound is useful in research aimed at understanding neurodegenerative diseases and exploring potential therapeutic strategies for conditions associated with cholinergic system dysfunction. -
BChE Inhibitor
BChE-IN-10 is a potent mixed-type inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 value of 6.4 μM. Isolated from Bletilla striata, this compound effectively modulates cholinergic activity and holds potential in the investigation of Alzheimer’s disease (AD) pathology. Its application in neurodegenerative research makes it a valuable tool for studying BChE-related mechanisms and therapeutic strategies. -
Stable Isotope
Acephate-d3 is a deuterated analogue of Acephate, serving as a stable isotope. This compound primarily acts as an anticholinesterase insecticide, exhibiting cholinotoxic effects. While it demonstrates weak inhibition of rat acetylcholinesterase (AChE), it exhibits potent inhibition of AChE in cockroaches, making it valuable for research in insect physiology and pest management studies. -
AChE Inhibitor
Hydrangenol 8-O-glucoside is an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 22.66 μM. Isolated from Hydrangea macrophyllus, this compound exhibits significant activity in inhibiting the PCA (passive cutaneous anaphylaxis) reaction. Its properties make it a useful tool for research on neurodegenerative diseases and allergic responses.
