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8-Hydroxydihydrochelerythrine

AChE Inhibitor

8-Hydroxydihydrochelerythrine is a selective and competitive inhibitor of acetylcholinesterase (AChE) with an IC50 of 0.61 μM. Derived from the roots of Zanthoxylum nitidum, this benzophenanthridine alkaloid enhances acetylcholine levels in cholinergic synapses, thereby facilitating improved cholinergic neurotransmission. Its unique mechanism makes 8-Hydroxydihydrochelerythrine valuable for research into neurodegenerative disorders, particularly Alzheimer's disease and related dementias.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	4070-42-2
Applications	AChE Inhibitor
Formula	C₂₁H₁₉NO₅
Molecular Weight	365.38
SMILES	OC1C2=C(C3=CC=C4C=C5OCOC5=CC4=C3N1C)C=CC(OC)=C2OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.