Fig. 1 · Structure
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JNJ-1930942
nAChR Modulator
JNJ-1930942 is a selective positive allosteric modulator of the α(7) nicotinic acetylcholine receptor (nAChR) that effectively crosses the blood-brain barrier. This compound facilitates heightened intracellular Ca2+ levels and promotes neurotransmission at synapses in the hippocampal dentate gyrus. Additionally, JNJ-1930942 has been shown to reverse sensory gating deficits in DBA/2 mouse models, making it a valuable tool for research in neuropsychiatric disorders and synaptic physiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 929562-28-7 |
| Applications | nAChR Modulator |
| Formula | C16H11F4N3OS |
| Molecular Weight | 369.34 |
| SMILES | OCC1=C(C2=CC=NC=C2)N=C(NC3=CC=C(F)C(C(F)(F)F)=C3)S1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.