Fasciculin-II

Catalog No.: A78768
AChE Inhibitor
Fasciculin-II is a potent inhibitor of acetylcholinesterase (AChE), an enzyme critical for neurotransmitter regulation. By blocking AChE activity, Fasciculin-II enhances cholinergic transmission, making it a valuable tool for research in neurobiology and related fields. Its biological activity is particularly relevant in studies of synaptic function and neurodegenerative diseases.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFasciculin-II is a potent inhibitor of acetylcholinesterase (AChE), an enzyme critical for neurotransmitter regulation. By blocking AChE activity, Fasciculin-II enhances cholinergic transmission, making it a valuable tool for research in neurobiology and related fields. Its biological activity is particularly relevant in studies of synaptic function and neurodegenerative diseases.
Product Information
Catalog NumA78768
FormulaC276H438N88O90S10
Molecular Weight6749.62
CAS Number95506-56-2
SequenceThr-Met-Cys-Tyr-Ser-His-Thr-Thr-Thr-Ser-Arg-Ala-Ile-Leu-Thr-Asn-Cys-Gly-Glu-Asn-Ser-Cys-Tyr-Arg-Lys-Ser-Arg-Arg-His-Pro-Pro-Lys-Met-Val-Leu-Gly-Arg-Gly-Cys-Gly-Cys-Pro-Pro-Gly-Asp-Asp-Asn-Leu-Glu-Val-Lys-Cys-Cys-Thr-Ser-Pro-Asp-Lys-Cys-Asn-Tyr (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52;Cys53-Cys59)
Sequence shorteningTMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52;Cys53-Cys59)
SynonymsFas-2
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