AChE/BChE-IN-6 is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 0.809 µM for AChE and 2.248 µM for BChE, with limited activity against hMAO-B. This compound effectively penetrates the blood-brain barrier, making it a valuable tool for research focused on Alzheimer's disease. Its ability to inhibit cholinesterases suggests potential applications in studies aiming to understand and develop treatments for neurodegenerative conditions characterized by cholinergic dysfunction.
AChE/BChE-IN-6 is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 0.809 µM for AChE and 2.248 µM for BChE, with limited activity against hMAO-B. This compound effectively penetrates the blood-brain barrier, making it a valuable tool for research focused on Alzheimer's disease. Its ability to inhibit cholinesterases suggests potential applications in studies aiming to understand and develop treatments for neurodegenerative conditions characterized by cholinergic dysfunction.
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