Echothiopate chloride is a potent, irreversible inhibitor of cholinesterase (ChE). By forming a covalent bond with the serine residue at the active site of ChE, it permanently inactivates the enzyme, necessitating de novo enzyme synthesis for restoration of activity. This long-lasting inhibition makes echothiopate chloride effective in ocular applications, particularly as a miotic agent in the management of chronic glaucoma and accommodative esotropia, with effects that can persist for over a week.
Echothiopate chloride is a potent, irreversible inhibitor of cholinesterase (ChE). By forming a covalent bond with the serine residue at the active site of ChE, it permanently inactivates the enzyme, necessitating de novo enzyme synthesis for restoration of activity. This long-lasting inhibition makes echothiopate chloride effective in ocular applications, particularly as a miotic agent in the management of chronic glaucoma and accommodative esotropia, with effects that can persist for over a week.
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