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DTNP

Catalog No.: A43788
Fluorescent probe
DTNP is a BchE-activated near infrared (NIR) fluorescent probe known for its ability to permeate the blood-brain barrier. Upon activation by butyrylcholinesterase (BchE), DTNP exhibits inhibitory effects on enzyme activity, making it a valuable tool in the study of Alzheimer's disease (AD). Its unique properties facilitate research into the pathological mechanisms and potential therapeutic strategies related to neurodegeneration.
DTNP 3010266-66-4 Fluorescent probe
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDTNP is a BchE-activated near infrared (NIR) fluorescent probe known for its ability to permeate the blood-brain barrier. Upon activation by butyrylcholinesterase (BchE), DTNP exhibits inhibitory effects on enzyme activity, making it a valuable tool in the study of Alzheimer's disease (AD). Its unique properties facilitate research into the pathological mechanisms and potential therapeutic strategies related to neurodegeneration.
Product Information
Catalog NumA43788
FormulaC63H67IN8O6
Molecular Weight1159.16
CAS Number3010266-66-4
SMILESCC1(C(/C=C/C(CCC2)=C3C2=CC4=C(O3)C=C(OC(C5CC5)=O)C=C4)=[N+](C6=CC=CC=C61)CCCC7=CN(CCNC(C8=CC=CC(C(NC9=CC=CC(C(NCC%10=CC=CC=C%10CN(CC)CC)=O)=C9)=O)=C8)=O)N=N7)C.[I-]
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Neuronal Signaling > AChE
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