Fig. 1 · Structure
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Jatrorrhizine chloride
Bioactive Alkaloid
Jatrorrhizine chloride is a bioactive alkaloid derived from Coptis chinensis, exhibiting diverse pharmacological properties such as neuroprotection, antimicrobial action, antiplasmodial effects, and antioxidant activity. This compound acts as a potent and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 872 nM, demonstrating over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine chloride inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through blockade of uptake-2 transporters, making it a valuable tool in neurological and pharmacological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 6681-15-8 |
| Applications | Bioactive Alkaloid |
| Formula | C20H20ClNO4 |
| Molecular Weight | 373.83 |
| SMILES | COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.