Fig. 1 · Structure
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Coumarin 106
AChE/BChE Inhibitor
Coumarin 106 is a dipolar laser dye that serves as an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It exhibits mixed-type inhibition of AChE with a pIC50 of 4.97 and a Ki value of 2.36 μM, while also inhibiting BChE with a slightly lower potency (pIC50 of 4.56). This compound is valuable in studying cholinergic signaling pathways and may aid in the exploration of therapeutic strategies for disorders linked to cholinergic dysfunction.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 41175-45-5 |
| Applications | AChE/BChE Inhibitor |
| Formula | C18H19NO2 |
| Molecular Weight | 281.35 |
| Synonyms | Coumarin 478 |
| SMILES | O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C5=C1CCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.