hAChE-IN-6 is a selective acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 of 0.16 μM. It also inhibits human butyrylcholinesterase (hBuChE) and glycogen synthase kinase 3 beta (GSK3β) with IC50 values of 0.69 μM and 0.26 μM, respectively. Notably, hAChE-IN-6 inhibits the self-aggregation of tau protein and amyloid beta 1-42, making it a valuable reagent for research into Alzheimer's disease pathogenesis and therapeutic strategies.
hAChE-IN-6 is a selective acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 of 0.16 μM. It also inhibits human butyrylcholinesterase (hBuChE) and glycogen synthase kinase 3 beta (GSK3β) with IC50 values of 0.69 μM and 0.26 μM, respectively. Notably, hAChE-IN-6 inhibits the self-aggregation of tau protein and amyloid beta 1-42, making it a valuable reagent for research into Alzheimer's disease pathogenesis and therapeutic strategies.
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