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Catalog No.
Product Name
Application
Product Information
Citations
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Cholinesterase (ChE) Inhibitor
AChE-IN-3 is a cholinesterase (ChE) inhibitor that demonstrates moderate inhibitory activity against acetylcholinesterase (AChE). Additionally, it exhibits strong nitric oxide (NO) inhibitory activity with an EC50 of 0.57 μM. This compound is suitable for research applications focused on neurodegenerative diseases and signaling pathways involving nitric oxide. -
Ach Inhibitor
AChE-IN-103 is a potent acetylcholinesterase (AChE) inhibitor that demonstrates log IC50 values of 1.477 and 2.2 in alignment models I and II, respectively. This compound plays a significant role in the research of Alzheimer’s disease, where it may help elucidate the mechanisms of cholinergic dysfunction. AChE-IN-103 is valuable for studies aimed at developing therapeutic strategies targeting cognitive decline associated with this neurodegenerative disorder. -
AChE Inhibitor
Pseudocoptisine acetate is a quaternary alkaloid derived from the benzylisoquinoline scaffold, isolated from Corydalis Tuber. It functions as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 12.8 μM. This compound demonstrates significant anti-inflammatory and anti-amnestic properties, making it valuable for research in neurodegenerative diseases and cognitive impairment studies. -
ChE Inhibitor
SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. By enhancing the release of acetylcholine in the brain, SM 10888 offers potential therapeutic benefits in the context of neurological disorders. This compound is particularly relevant for research focused on Alzheimer's disease and other cholinergic dysfunctions. -
BChE Inhibitor
BChE-IN-34 is a highly selective inhibitor of butyrylcholinesterase (BChE) with an IIC50 of 25 nM, demonstrating excellent selectivity over acetylcholinesterase. This compound exhibits neuroprotective and antioxidant properties, making it a valuable tool for research into neurodegenerative diseases and cholinergic signaling pathways. Its specificity and efficacy position BChE-IN-34 as a promising candidate for studying the therapeutic potential of targeting BChE in various biological contexts. -
AChE Inhibitor
Stacofylline hydrochloride is a potent inhibitor of acetylcholinesterase (AChE) with an IC50 range of 5-50 nM. This xanthine derivative exhibits notable anti-amnesic and promnesic effects, making it relevant for research into memory enhancement and cognitive function. Its pharmacological properties position it as a valuable tool in Alzheimer's disease studies and other neurological research applications. -
AChE/BChE/LOX Inhibitor
Decaffeoylacteoside is an inhibitor targeting acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and lipoxygenase (LOX). This compound exhibits moderate inhibitory activity, making it relevant for research into neurodegenerative diseases and inflammation. Its ability to modulate these enzymes provides potential applications in pharmacological studies aimed at developing therapeutic agents for conditions involving cholinergic dysregulation and oxidative stress. -
AChE/BChE Inhibitor
AChE-IN-15 is a reversible inhibitor of human acetylcholinesterase (huAChE) with an IC50 value of 6.8 μM and human butyrylcholinesterase (huBChE) with an IC50 value of 16.1 μM. This compound exhibits significant antioxidant activity and has potential applications in research related to Alzheimer's disease. AChE-IN-15 is a valuable tool for investigating cholinesterase inhibition and its role in neurodegeneration. -
Acetylcholinesterase inhibitor
AChE-IN-36 is a potent inhibitor of acetylcholinesterase, exhibiting an IC50 of 0.04 μM. This compound influences reactive oxygen species (ROS) levels and modulates the gene expression of NRF2, making it a valuable tool for studies on neurodegenerative diseases and oxidative stress responses. Its activity is relevant for research focused on cholinergic signaling and cellular antioxidant pathways. -
AChE Inhibitor
Ostruthol is a coumarin compound that functions as a potent inhibitor of acetylcholinesterase (AChE). This inhibition contributes to increased levels of acetylcholine, a neurotransmitter that may be diminished in neurodegenerative disorders. Ostruthol is primarily utilized in Alzheimer's disease research to explore its potential therapeutic effects and mechanisms of action. -
AChE Inhibitor
AChE-IN-20 is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 397.32 nM and a Ki value of 335.76 nM. In addition to its primary target, AChE-IN-20 exhibits significant inhibitory activity against human carbonic anhydrases I and II, and α-glucosidase, with IC50 values of 84.14 nM, 69.24 nM, and 52.08 nM, respectively. This compound is valuable for research into neurodegenerative diseases and enzymatic regulation, providing insights into potential therapeutic strategies. -
AChE Inhibitor
2,3,9,10-Tetrahydroxyberberine bromide is a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 7.8 μM. This compound also demonstrates significant free radical scavenging activity, as evidenced by an IC50 of 43 μM in the DPPH assay. It is particularly relevant for studies focusing on Alzheimer's disease research and the exploration of neuroprotective mechanisms. -
AChE Inhibitor
(Rac)-Sclerone is an acetylcholinesterase (AChE) inhibitor derived from the green husk of Carya illinoinensis. It demonstrates significant AChE inhibition with an IC50 value of 192.65 ± 10.12 μg/mL. This compound is utilized in research applications targeting Alzheimer's disease and other neurodegenerative disorders, where modulation of cholinergic activity is of interest. -
AChE Inhibitor
Epi-galantamine is a diastereomer of galantamine that functions as an acetylcholinesterase (AChE) inhibitor, demonstrating an EC50 of 45.7 μM. This alkaloid is extracted from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine is notably utilized in research exploring neurodegenerative diseases and cognitive enhancement, contributing to studies on cholinergic signaling and potential therapeutic interventions. -
Cholinesterase Inhibitor
AChE-IN-41 is a cholinesterase inhibitor designed to enhance acetylcholine levels by preventing its breakdown. This hybrid compound of Galantamine and Memantine demonstrates significant inhibition of cholinesterase activity, offering valuable insights for neurological research. AChE-IN-41 exhibits enhanced plasma stability and similar microsomal stability in vitro, although it possesses a shorter half-life and faster clearance in vivo, making it suitable for studies on cholinergic signaling and potential therapeutic applications in neurodegenerative diseases. -
Cholinesterase (ChE) Inhibitor
eeAChE-IN-1 is a potent inhibitor of cholinesterase (ChE), exhibiting an IC50 value of 23 nM. This compound is valuable for research applications related to neurodegenerative disorders and the modulation of cholinergic signaling pathways. Its efficacy in inhibiting ChE makes it a significant tool for studying acetylcholine metabolism and related biological processes. -
AChE/BChE Inhibitor
AChE/BChE-IN-19 is a nicotinic hydrazide derivative that acts as an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 21.45 nM and 18.42 nM, respectively. This compound is particularly relevant for studies investigating cholinergic dysfunction in neurodegenerative diseases, such as Alzheimer's disease. Its potent inhibitory activity makes it a valuable tool for exploring therapeutic strategies targeting cholinergic pathways. -
AChE Inhibitor
Methyl ganoderate A acetonide is a lanostane triterpene that functions as a potent acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 18.35 μM. This natural compound, extracted from the fruiting bodies of Ganoderma lucidum, is utilized in research efforts focused on Alzheimer's disease (AD). Its inhibition of AChE makes it a valuable tool for investigating therapeutic strategies for cognitive decline associated with neurodegenerative disorders. -
Cholinesterase (ChE) Inhibitor
Floramultine ((S)-Floramultine) is a reversible inhibitor of cholinesterase (ChE), demonstrating moderate potency and selectivity for various cholinesterase isoforms. This compound, derived from plant sources, exhibits significant cholinergic activity and can be utilized in research exploring the modulation of cholinergic neurotransmission. Applications include studies related to neurodegenerative disorders and the development of therapeutic agents targeting cholinergic dysfunction. -
BChE Inhibitor
Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 of 0.9 μM, demonstrating moderate inhibition of acetylcholinesterase (AChE) with an IC50 of 342.9 μM. This compound exhibits vasorelaxant properties and potential anti-tumor activity. Isograndifoliol is relevant for research focused on neurodegenerative diseases, particularly in studies targeting dementia. -
AChE Inhibitor
Heliosupine is a pyrrolizidine alkaloid that acts as an acetylcholinesterase (AChE) inhibitor, exhibiting a reported IC50 of 0.57 mM. This compound demonstrates significant biological activity by deterring generalist herbivores, making it a valuable tool in ecological and pharmacological research. Its AChE inhibitory properties may also have implications for the study of neurodegenerative diseases and chemical ecology. -
AChE Inhibitor
AChE-IN-47 is a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.24 μM. This compound effectively hinders the self-aggregation of amyloid β peptides, demonstrating neuroprotective properties. Additionally, AChE-IN-47 significantly reduces intracellular accumulation of reactive oxygen species, making it a valuable tool for research in neurodegenerative disease models and studies focused on oxidative stress. -
sEH/AChE Inhibitor
sEH/AChE-IN-1 is a dual inhibitor targeting soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). This compound exhibits significant biological activity in reducing neuroinflammation and memory impairment, making it a valuable tool for studying neurodegenerative diseases. Its application is particularly relevant in Alzheimer's disease research, where it may help elucidate disease mechanisms and potential therapeutic strategies. -
AChE Inhibitor
AChE-IN-10 is a highly effective inhibitor of acetylcholinesterase (AChE), with an IC50 value of 2.4 nM. This compound demonstrates significant neuroprotective effects by enhancing neuronal morphology and increasing cell viability, while also reducing tau phosphorylation at the S396 residue. Additionally, AChE-IN-10 has been shown to decrease amyloid aggregation in conjunction with AChE activity, making it a valuable tool for research in neurodegenerative diseases and cognitive disorders. -
BChE Inhibitor
BChE-IN-25 is a selective inhibitor of butyrylcholinesterase (BChE), exhibiting an inhibitory concentration (IC50) of 3.77 μM. This compound demonstrates a 22-fold selectivity for BChE over acetylcholinesterase (AChE), making it a valuable tool for research applications in neurobiology and therapeutic development targeting cholinergic dysfunction. Researchers can utilize BChE-IN-25 to investigate the role of BChE in various physiological and pathological processes. -
BChE Inhibitor
BChE-IN-38 is a potent butyrylcholinesterase (BChE) inhibitor demonstrating impressive Ki values of 62.05 nM for human carbonic anhydrase I (hCAI), 28.78 nM for human carbonic anhydrase II (hCAII), 14.09 nM for acetylcholinesterase (AChE), and 1.15 nM for BChE. In addition to its inhibitory effects, BChE-IN-38 exhibits notable cytotoxic activity. This compound is essential for research applications focusing on neurodegenerative disorders, drug development targeting cholinergic systems, and the study of enzyme inhibition mechanisms. -
AChE Inhibitor
Acotiamide-d6 is a deuterated form of Acotiamide, an orally active and first-in-class gastroprokinetic agent that acts as an acetylcholinesterase (AChE) inhibitor. This compound enhances gastrointestinal motility and is primarily used in research applications related to functional dyspepsia. Its unique isotopic labeling allows for advanced studies in pharmacokinetics and metabolic pathways, providing valuable insights into the drug's action and efficacy. -
AChE Inhibitor
Axillaridine A is an acetylcholinesterase (AChE) inhibitor derived from Sarcococca hookeriana var. digyna. It effectively inhibits the catalytic activity of AChE, making it a valuable tool in the study of neurodegenerative diseases and cognitive function. This compound has potential applications in research exploring the modulation of cholinergic signaling and therapeutic strategies for conditions such as Alzheimer's disease. -
Acetylcholinesterase Inhibitor
Quinolactacin A2 is an acetylcholinesterase inhibitor that effectively reduces the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. Additionally, this compound has been shown to inhibit tumor necrosis factor (TNF) production, which may have implications in inflammatory and neurodegenerative research. Quinolactacin A2 is valuable in studies investigating cholinergic signalling and its role in various pathophysiological conditions. -
AChE Inhibitor
Arisugacin B is a selective acetylcholinesterase (AChE) inhibitor with potent oral bioactivity. Its mechanism of action involves the inhibition of AChE, which plays a crucial role in neurotransmission by regulating acetylcholine levels. This compound is useful in research applications focused on neurodegeneration and related disorders, offering insights into potential therapeutic strategies for conditions such as Alzheimer's disease. -
AChE Inhibitor
AE027 is a potent inhibitor of acetylcholinesterase (AChE), effectively targeting both wild-type and the resistant F348Y mutation, with IC50 values of 10 μM and 43 μM, respectively. This compound exhibits significant biological activity in blocking AChE, making it a valuable tool for research in neurodegenerative disorders and studies related to cholinergic signaling. AE027 provides potential insights into therapeutic strategies for conditions associated with AChE dysregulation. -
AChE Inhibitor
Undulatine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 7.4 μM. This compound is capable of crossing the blood-brain barrier through passive permeation, making it a valuable tool for investigating the pathophysiology of Alzheimer's disease. Its ability to modulate cholinergic activity positions Undulatine as a promising candidate for research into therapeutic strategies for neurodegenerative disorders. -
AChE Inhibitor
N-Methylcalycinine is a natural product that acts as an acetylcholinesterase (AChE) inhibitor. Isolated from the roots of Stephania epigaea, it possesses potential therapeutic implications in various research fields, including asthma, cancer, dysentery, fever, hyperglycemia, intestinal disorders, inflammation, sleep disturbances, and tuberculosis. This compound may be valuable for studies exploring its effects on neurotransmitter regulation and related biological processes. -
Acetylcholinesterase Inhibitor
Samioside is an acetylcholinesterase inhibitor primarily extracted from the plants Phlomis nissolii and P. capitata. It exhibits notable free-radical scavenging and antimicrobial properties, making it a valuable compound for biological research. Samioside is particularly relevant for studies investigating its potential anti-Alzheimer’s effects, offering insights into therapeutic avenues for neurodegenerative conditions. -
AChE Inhibitor
Buxbodine B is an acetylcholinesterase (AChE) inhibitor with an IC50 of 50 μM. It demonstrates significant potential in the study of neurodegenerative diseases, particularly Alzheimer's disease, by modulating cholinergic transmission. Its inhibitory action on AChE facilitates the exploration of therapeutic strategies aimed at enhancing cognitive function and memory retention in affected populations. -
AChE Inhibitor
Arisugacin D is an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 3.5 μM. This compound is notable for its potential to enhance synaptic acetylcholine levels, making it useful in studies related to neurodegenerative diseases such as Alzheimer's. The inhibition of AChE facilitates the investigation of cholinergic signaling pathways and the development of therapeutic strategies targeting cognitive decline. -
AChE1 Inhibitor
AL284 is a potent inhibitor of Anopheles gambiae acetylcholinesterase 1 (AgAChE1), targeting key residues Tyr489Ag and Trp441Ag within the enzyme structure. This compound demonstrates significant biological activity in disrupting neurotransmitter breakdown, which is critical for the survival of disease-transmitting mosquitoes. AL284 is valuable for research applications focused on controlling mosquito populations and studying vector-borne diseases. -
Cholinesterase Inhibitor
Neostigmine hydroxide is a potent cholinesterase inhibitor that enhances acetylcholine levels at neuromuscular junctions. This compound is primarily utilized in research related to myasthenia gravis and other neuromuscular disorders, aiding in the exploration of muscular function and neuropharmacology. Its ability to counteract muscle weakness makes it a valuable tool for studying therapeutic interventions in cholinergic signaling. -
AChE Inhibitor
Coroxon, an AChE inhibitor, is an oxidative metabolite of the organophosphate insecticide Coumaphos. This compound exhibits significant insecticidal and acaricidal activity, making it valuable for pest control research. Additionally, Coroxon can be hydrolyzed by phosphotriesterases from microorganisms such as Nocardia asteroides, resulting in the production of the fluorescent compound Chlorferon, which can be utilized in biochemical assays and studies related to enzyme activity. -
AChE Inhibitor
Salvianolic acid H is a potent inhibitor of acetylcholinesterase (AChE), serving to enhance cholinergic neurotransmission. Its primary biological activity includes the potential modulation of neurodegenerative processes associated with cognitive decline. This compound is valuable for research applications aimed at understanding Alzheimer's disease and other conditions linked to cholinergic deficits. -
hAChE Inhibitor
7-Methoxytacrine is a potent inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM. This compound is utilized in research related to Alzheimer's disease, highlighting its potential role in modulating neurotransmitter levels and improving cognitive function. Its mechanism of action makes it a valuable tool for investigating therapeutic strategies in neurodegenerative disorders. -
ChE Inhibitor
Lycodine is a lycopodium alkaloid that acts as a cholinesterase inhibitor. It demonstrates significant anticholinesterase activity, making it a valuable tool for research into neurological disorders and cognitive function. Its potential applications extend to studying mechanisms of acetylcholine modulation and developing therapeutic approaches for conditions such as Alzheimer’s disease. -
AChE Inhibitor
Graphislactone A is an acetylcholinesterase (AChE) inhibitor, which demonstrates significant potential in the investigation of neurodegenerative diseases. With an IC50 value of 27 μM, it effectively inhibits AChE activity, contributing to enhanced cholinergic signaling. Additionally, Graphislactone A exhibits antioxidant properties, making it a valuable compound for research focused on oxidative stress-related disorders. -
Cholinesterase (ChE) Inhibitor
Echinenone acts as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 16.29 μg/mL. This compound demonstrates anti-Aβ(25-35) activity and has been shown to decrease malondialdehyde (MDA) levels while enhancing the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). These properties indicate its potential use in research focused on neuroprotection and alleviating oxidative stress-related damage. -
AChE Inhibitor
Isodimethoate is an acetylcholinesterase (AChE) inhibitor that demonstrates potent anticholinesterase activity. As a thermal decomposition product of Dimethoate, it effectively inhibits AChE in human red blood cells, making it valuable for studying cholinergic signaling and related neurochemical pathways. This compound is frequently utilized in research focused on neurotoxicology and the effects of organophosphates on enzymatic activity. -
AChE Inhibitor
Galactamine is an acetylcholinesterase (AChE) inhibitor that plays a crucial role in modulating neurotransmitter levels by preventing the breakdown of acetylcholine. This compound is primarily utilized in research investigating Alzheimer's disease and other neurodegenerative disorders, where it helps to elucidate the mechanisms underlying cognitive decline and potential therapeutic strategies. Galactamine's ability to enhance cholinergic signaling makes it a valuable tool in the study of efficacy and safety in neuropharmacology. -
hBuChE Inhibitor
Deoxynojirimycin tetrabenzyl ether is an inhibitor of human butyrylcholinesterase (hBuChE), with an IC50 value of 2.0 μM. This compound is utilized in research focused on neurological disorders and cholinergic system regulation, making it valuable for studies involving enzyme inhibition and potential therapeutic applications in cognitive decline. -
AChE Inhibitor
Arisugacin C is an acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 2.5 μM, demonstrating its potent activity in modulating cholinergic neurotransmission. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s disease, where AChE inhibition may alleviate cognitive decline. Its selectivity and efficacy make it a useful tool in studying the mechanisms of cholinergic signaling and developing potential therapeutic strategies. -
Monoamine Oxidase Inhibitor
4-Chlorochalcone is a selective monoamine oxidase inhibitor, demonstrating an IC50 of 0.082 μM against hMAO-B and 9.95 μM against hMAO-A. This compound also shows inhibitory activity towards acetylcholinesterase, with an IC50 of 2.79 μM. As a chalcone derivative, 4-Chlorochalcone is valuable for research focused on neurodegenerative diseases and the modulation of neurotransmitter levels. -
Cholinesterase (ChE) Inhibitor
AChE-IN-83 is a potent acetylcholinesterase (AChE) inhibitor targeting cholinesterases in various biological systems. This compound effectively inhibits the growth and behavior of Aphelenchoides oryzae, a nematode pathogen in rice, demonstrating an LC50 value of 19.0 μg/mL over 48 hours. AChE-IN-83 disrupts the nematode cuticle, promoting the accumulation of reactive oxygen species, lipofuscin, and lipids, thereby offering applications in nematode management and enhancing rice seed health.
