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2,3,9,10-Tetrahydroxyberberine bromide

AChE Inhibitor

2,3,9,10-Tetrahydroxyberberine bromide is a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 7.8 μM. This compound also demonstrates significant free radical scavenging activity, as evidenced by an IC50 of 43 μM in the DPPH assay. It is particularly relevant for studies focusing on Alzheimer's disease research and the exploration of neuroprotective mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2847856-62-4
Applications	AChE Inhibitor
Formula	C₁₇H₁₄BrNO₄
Molecular Weight	376.20
SMILES	OC1=C(O)C2=C[N+]3=C(C4=CC(O)=C(C=C4CC3)O)C=C2C=C1.[Br-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.