Cnidilide is a natural product of alkylphthalein that primarily targets the inhibition of pro-inflammatory pathways. It significantly reduces the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by downregulating the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in response to lipopolysaccharide (LPS) stimulation. Additionally, Cnidilide suppresses the production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α. This compound specifically inhibits the phosphorylation of p38 MAPK and JNK, thereby blocking the signaling pathways mediated by AP-1 and NF-κB, making it a valuable tool for researching inflammation-related conditions.
Cnidilide is a natural product of alkylphthalein that primarily targets the inhibition of pro-inflammatory pathways. It significantly reduces the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by downregulating the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in response to lipopolysaccharide (LPS) stimulation. Additionally, Cnidilide suppresses the production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α. This compound specifically inhibits the phosphorylation of p38 MAPK and JNK, thereby blocking the signaling pathways mediated by AP-1 and NF-κB, making it a valuable tool for researching inflammation-related conditions.
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