CKD-712 is a tetrahydroisoquinoline derivative that functions as a potent NF-κB inhibitor. This compound selectively inhibits MMP-9 while leaving MMP-2 unaffected and downregulates the expression of key inflammatory and cell cycle proteins such as TNF-α, IL-6, cyclin A, cyclin B, and CDK-1. By blocking NF-κB activation and its translocation to the nucleus, CKD-712 reduces levels of inflammatory factors and pro-tumor proteins, leading to G2/M phase arrest in cancer cells and inhibiting cell invasion. It is suitable for investigating sepsis, myocardial ischemia-reperfusion injury, and non-small cell lung cancer.
CKD-712 is a tetrahydroisoquinoline derivative that functions as a potent NF-κB inhibitor. This compound selectively inhibits MMP-9 while leaving MMP-2 unaffected and downregulates the expression of key inflammatory and cell cycle proteins such as TNF-α, IL-6, cyclin A, cyclin B, and CDK-1. By blocking NF-κB activation and its translocation to the nucleus, CKD-712 reduces levels of inflammatory factors and pro-tumor proteins, leading to G2/M phase arrest in cancer cells and inhibiting cell invasion. It is suitable for investigating sepsis, myocardial ischemia-reperfusion injury, and non-small cell lung cancer.
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