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Distinctin

Catalog No.: A49479
Antimicrobial Peptide
Distinctin is an antimicrobial peptide extracted from frog skin, exhibiting potent antibacterial activity against pathogens such as Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli, with minimum inhibitory concentrations (MIC) of 14.5 μM and 28.0 μM. This compound plays a crucial role in studies focused on antimicrobial resistance and therapeutic applications in treating bacterial infections. Its unique mechanism of action enhances its utility in various microbiological and biomedical research endeavors.
Distinctin 857394-09-3 Antimicrobial Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDistinctin is an antimicrobial peptide extracted from frog skin, exhibiting potent antibacterial activity against pathogens such as Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli, with minimum inhibitory concentrations (MIC) of 14.5 μM and 28.0 μM. This compound plays a crucial role in studies focused on antimicrobial resistance and therapeutic applications in treating bacterial infections. Its unique mechanism of action enhances its utility in various microbiological and biomedical research endeavors.
Product Information
Catalog NumA49479
FormulaC131H226N40O35S
Molecular Weight2953.51
CAS Number857394-09-3
SequenceAsn-Leu-Val-Ser-Gly-Leu-Ile-Glu-Ala-Arg-Lys-Tyr-Leu-Glu-Gln-Leu-His-Arg-Lys-Leu-Lys-Asn-Cys-Lys-Val
Sequence shorteningNLVSGLIEARKYLEQLHRKLKNCKV
SMILES[C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)C)C(O)=O)=O)CCCCN)=O)CS)=O)CC(N)=O)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCCNC(=N)N)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)N)=O)CC(C)C)=O)C(C)C)=O)CO)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)C)=O)CCCNC(=N)N)=O)CCCCN)=O
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