BIBO3304 free base is a potent nonpeptide antagonist of the neuropeptide Y Y1 receptor. It demonstrates subnanomolar affinity for human and rat Y1 receptors, with IC50 values of 0.38 nM and 0.72 nM, respectively. This compound effectively inhibits food intake stimulated by neuropeptide Y (NPY) and fasting conditions, making it a valuable tool for studies related to appetite regulation and metabolic disorders.
BIBO3304 free base is a potent nonpeptide antagonist of the neuropeptide Y Y1 receptor. It demonstrates subnanomolar affinity for human and rat Y1 receptors, with IC50 values of 0.38 nM and 0.72 nM, respectively. This compound effectively inhibits food intake stimulated by neuropeptide Y (NPY) and fasting conditions, making it a valuable tool for studies related to appetite regulation and metabolic disorders.
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