(R)-JNJ-31020028 is a potent and selective antagonist of the neuropeptide Y Y2 receptor, demonstrating high affinity with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively. It exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors. This compound has been shown to elicit antidepressant-like effects, making it a valuable tool for research in neuropsychiatric disorders and therapeutics targeting neuropeptide signaling pathways.
(R)-JNJ-31020028 is a potent and selective antagonist of the neuropeptide Y Y2 receptor, demonstrating high affinity with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively. It exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors. This compound has been shown to elicit antidepressant-like effects, making it a valuable tool for research in neuropsychiatric disorders and therapeutics targeting neuropeptide signaling pathways.
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