Nocistatin is a neuropeptide that acts as an endogenous ligand for the orphan opioid receptor-like receptor. It functions as a functional antagonist of neuropeptide nociceptin/orphanin FQ (Noc/OFQ), inhibiting 5-HT release through a Gi/o protein-mediated pathway. Nocistatin has been shown to block nociceptin-induced allodynia and hyperalgesia, making it a valuable tool for research into pain mechanisms and neuropeptide signaling.
Nocistatin is a neuropeptide that acts as an endogenous ligand for the orphan opioid receptor-like receptor. It functions as a functional antagonist of neuropeptide nociceptin/orphanin FQ (Noc/OFQ), inhibiting 5-HT release through a Gi/o protein-mediated pathway. Nocistatin has been shown to block nociceptin-induced allodynia and hyperalgesia, making it a valuable tool for research into pain mechanisms and neuropeptide signaling.
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