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GR231118

Catalog No.: A62256
Neuropeptide YY Receptor Antagonist
GR231118 is a selective antagonist for the human neuropeptide Y (NPY) Y1 receptor, exhibiting a competitive inhibition with a pKi of 10.4. This compound also demonstrates potent agonist activity at the human NPY Y4 receptor (pEC50=8.6; pKi=9.6) and weak agonist activity at both human and rat NPY Y2 and Y5 receptors. Additionally, GR231118 has significant affinity for the mouse NPY Y6 receptor (pKi=8.8), making it a valuable tool for studying neuropeptide Y signaling pathways and their implications in various physiological and pathological conditions.
GR231118 158859-98-4 Neuropeptide YY Receptor Antagonist
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5mg
$845.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGR231118 is a selective antagonist for the human neuropeptide Y (NPY) Y1 receptor, exhibiting a competitive inhibition with a pKi of 10.4. This compound also demonstrates potent agonist activity at the human NPY Y4 receptor (pEC50=8.6; pKi=9.6) and weak agonist activity at both human and rat NPY Y2 and Y5 receptors. Additionally, GR231118 has significant affinity for the mouse NPY Y6 receptor (pKi=8.8), making it a valuable tool for studying neuropeptide Y signaling pathways and their implications in various physiological and pathological conditions.
Product Information
Catalog NumA62256
FormulaC110H170N34O24
Molecular Weight2352.74
CAS Number158859-98-4
Sequence shorteningSequence 1:IEP-{Dpr}-YRLRY-NH2;Sequence 1':IEP-{Dpr}-YRLRY-NH2 (Amide bridge:Glu2-Dpr4';Dpr4-Glu2')
SMILESO=C1N2[C@](C(=O)N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)CNC(=O)CC[C@H](NC([C@H]([C@H](CC)C)N)=O)C(=O)N5C(C(=O)N[C@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC7=CC=C(O)C=C7)C(N)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)CNC(=O)CC[C@@H]1NC([C@H]([C@H](CC)C)N)=O)(CCC5)[H])(CCC2)[H]
Synonyms1229U91; GW1229
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