J-115814 is a potent and selective antagonist of the neuropeptide Y1 receptor, exhibiting Ki values of 1.4 nM for human Y1, 1.8 nM for rat Y1, and 1.9 nM for mouse Y1, with significantly lower affinity for other neuropeptide Y receptors. This compound has demonstrated the ability to inhibit feeding behaviors, making it a valuable tool in obesity and appetite regulation research. Its specificity and potency make J-115814 suitable for studies investigating neuropeptide signaling and related physiological processes.
J-115814 is a potent and selective antagonist of the neuropeptide Y1 receptor, exhibiting Ki values of 1.4 nM for human Y1, 1.8 nM for rat Y1, and 1.9 nM for mouse Y1, with significantly lower affinity for other neuropeptide Y receptors. This compound has demonstrated the ability to inhibit feeding behaviors, making it a valuable tool in obesity and appetite regulation research. Its specificity and potency make J-115814 suitable for studies investigating neuropeptide signaling and related physiological processes.
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