GALA is a pH-responsive amphipathic peptide that specifically targets lung endothelium. It undergoes a conformational change from random coil to α-helix at pH 5.0, leading to endosomal membrane destabilization and fusion. GALA-modified liposomes utilize clathrin-dependent endocytosis and transcytosis for efficient delivery, accumulating in lung tissues post-intravenous administration. This peptide enhances the cytosolic release of therapeutic agents such as siRNA and plasmids, facilitating increased gene transfection efficiency while maintaining low cytotoxicity. GALA is a valuable tool for investigating lung cancer metastasis and developing lung-targeted drug delivery systems.
GALA is a pH-responsive amphipathic peptide that specifically targets lung endothelium. It undergoes a conformational change from random coil to α-helix at pH 5.0, leading to endosomal membrane destabilization and fusion. GALA-modified liposomes utilize clathrin-dependent endocytosis and transcytosis for efficient delivery, accumulating in lung tissues post-intravenous administration. This peptide enhances the cytosolic release of therapeutic agents such as siRNA and plasmids, facilitating increased gene transfection efficiency while maintaining low cytotoxicity. GALA is a valuable tool for investigating lung cancer metastasis and developing lung-targeted drug delivery systems.
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