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E-76

Catalog No.: A74687
Anticoagulant Peptide
E-76 is an anticoagulant peptide that specifically inhibits blood coagulation by binding to exogenous coagulation factor VIIa (FVIIa). This interaction disrupts the coagulation cascade, making E-76 a valuable tool for studying blood coagulation disorders and related pathophysiological conditions. Its application extends to research focused on thrombotic diseases and therapeutics targeting coagulation pathways.
E-76 1926163-13-4 Anticoagulant Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE-76 is an anticoagulant peptide that specifically inhibits blood coagulation by binding to exogenous coagulation factor VIIa (FVIIa). This interaction disrupts the coagulation cascade, making E-76 a valuable tool for studying blood coagulation disorders and related pathophysiological conditions. Its application extends to research focused on thrombotic diseases and therapeutics targeting coagulation pathways.
Product Information
Catalog NumA74687
FormulaC97H139N27O29S2
Molecular Weight2211.44
CAS Number1926163-13-4
SequenceAc-Ala-Leu-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bridge:Cys3-Cys13)
Sequence shorteningAc-ALCDDPRVDRWYCQFVEG-NH2 (Disulfide bridge:Cys3-Cys13)
SMILESC(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(N[C@H](C(NCC(N)=O)=O)CCC(O)=O)=O)[C@@H](C)C)=O)=O)CCC(N)=O)=O)CSSC[C@H](NC([C@@H](NC([C@@H](NC(C)=O)C)=O)CC(C)C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N6C(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N3)(CCC6)[H]
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