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TAT-EE3

Catalog No.: A66093
Neuroprotective Peptide
TAT-EE3 is a neuroprotective peptide that disrupts the interaction between TRPM2 and N-methyl-D-aspartate receptors (NMDARs). By inhibiting TRPM2-induced increases in NMDAR surface expression and current amplitude, TAT-EE3 offers protective effects against neuronal damage. This reagent serves as an important tool for research focused on ischemic injury and related conditions, including the study of ischemic stroke both in vitro and in vivo.
TAT-EE3 2899218-49-4 Neuroprotective Peptide
Grouped product items
Size Price Stock Qty
1mg
$90.00
In stock
5mg
$235.00
In stock
10mg
$385.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTAT-EE3 is a neuroprotective peptide that disrupts the interaction between TRPM2 and N-methyl-D-aspartate receptors (NMDARs). By inhibiting TRPM2-induced increases in NMDAR surface expression and current amplitude, TAT-EE3 offers protective effects against neuronal damage. This reagent serves as an important tool for research focused on ischemic injury and related conditions, including the study of ischemic stroke both in vitro and in vivo.
Product Information
Catalog NumA66093
FormulaC135H228N48O49S
Molecular Weight3339.61
CAS Number2899218-49-4
SequenceTyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Glu-Asp-Thr-Asp-Ser-Ser-Glu-Glu-Met-Leu-Ala-Leu-Ala-Glu-Glu
Sequence shorteningYGRKKRRQRRREEDTDSSEEMLALAEE
SMILES[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)CCSC)=O)CCC(O)=O)=O)CCC(O)=O)=O)CO)=O)CO)=O)CC(O)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC1=CC=C(O)C=C1)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N
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