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TAT-CBD3A6K

Catalog No.: A66117
Modified TAT-CBD3 Peptide
TAT-CBD3A6K is a modified TAT-CBD3 peptide that primarily targets voltage-dependent calcium channels. This compound effectively reduces T- and R-type calcium currents in dorsal root ganglion (DRG) neurons, demonstrating notable anti-nociceptive properties. TAT-CBD3A6K has been shown to mitigate pain in a model of AIDS-induced peripheral neuropathy by preventing the CRMP-2-mediated enhancement of T- and R-type calcium channel activity, making it a valuable tool for studying pain mechanisms and peripheral neuropathy interventions.
TAT-CBD3A6K 1505463-57-9 Modified TAT-CBD3 Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTAT-CBD3A6K is a modified TAT-CBD3 peptide that primarily targets voltage-dependent calcium channels. This compound effectively reduces T- and R-type calcium currents in dorsal root ganglion (DRG) neurons, demonstrating notable anti-nociceptive properties. TAT-CBD3A6K has been shown to mitigate pain in a model of AIDS-induced peripheral neuropathy by preventing the CRMP-2-mediated enhancement of T- and R-type calcium channel activity, making it a valuable tool for studying pain mechanisms and peripheral neuropathy interventions.
Product Information
Catalog NumA66117
FormulaC137H250N60O32
Molecular Weight3249.83
CAS Number1505463-57-9
SequenceTyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Lys-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu
Sequence shorteningYGRKKRRQRRRARSRLKELRGVPRGL
SMILESC(N[C@H](C(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCCNC(=N)N)(=O)[C@H]1N(C([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C)=O)CCCNC(=N)N)=O)CO)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)CCC(O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)=O)C(C)C)=O)CCC1
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