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Sarafotoxin S6d

Catalog No.: A66342
Polypeptide Toxins
Sarafotoxin S6d is a polypeptide toxin derived from the venom of the Israeli sand boa constrictor, known for its cardiovascular effects. This compound induces significant electrocardiogram (ECG) alterations, including myocardial ischemia and hyperkalemia, while also promoting robust extracellular calcium-dependent vasoconstriction in rat aorta and positive inotropic effects in rat atria. Sarafotoxin S6d is valuable in the investigation of cardiovascular pathologies and related physiological mechanisms.
Sarafotoxin S6d 1446991-36-1 Polypeptide Toxins
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSarafotoxin S6d is a polypeptide toxin derived from the venom of the Israeli sand boa constrictor, known for its cardiovascular effects. This compound induces significant electrocardiogram (ECG) alterations, including myocardial ischemia and hyperkalemia, while also promoting robust extracellular calcium-dependent vasoconstriction in rat aorta and positive inotropic effects in rat atria. Sarafotoxin S6d is valuable in the investigation of cardiovascular pathologies and related physiological mechanisms.
Product Information
Catalog NumA66342
FormulaC112H163N27O34S5
Molecular Weight2591.98
CAS Number1446991-36-1
SequenceCys-Thr-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Ile-Ile-Trp (disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence shorteningCTCKDMTDKECLYFCHQDIIW (disulfide bridge: Cys1-Cys15, Cys3-Cys11)
SMILESC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC(=O)[C@H]2NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@]5(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@](NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@@H](N)CSSC2)[H])(CSSC5)[H])[H])[H])=O)CCC(N)=O)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=6C=7C(NC6)=CC=CC7
SynonymsSTX-b
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