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Caspase

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Items 1-50 of 87

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  1. A14915
    Q-VD-OPh

    Caspase inhibitor

    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
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  2. A16317
    Z-YVAD-FMK

    Caspase-1 inhibitor

    Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
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  3. A12697
    Z-DQMD-FMK

    Caspase-3 inhibitor

    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
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  4. A12800
    Z-IETD-FMK

    caspase 8 inhibitor

    Z-IETD-FMK is a specific inhibitor of caspase 8.
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  5. A14358
    Z-LEHD-FMK

    Caspase-9 Inhibitor

    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
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  6. A13503
    Z-DEVD-FMK

    Caspase-3 Inhibitor

    Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
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  7. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  8. A14100
    Nivocasan (GS-9450)

    Caspase inhibitor

    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
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  9. A10984
    VX-765 (Belnacasan)

    Caspase-1/4 inhibitor

    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
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  10. A15300
    Ivachtin

    Caspase-3 inhibitor

    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
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  11. A21557
    ML132

    caspase 1 inhibitor

    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM.
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  12. A25077
    Z-VA-DL-D-FMK

    Caspase Inhibitor

    Z-VA-DL-D-FMK is an irreversible caspase inhibitor that targets and binds to caspases, modulating their activity. This compound enhances the sensitivity of TNF-α, thereby influencing apoptotic pathways. Additionally, Z-VA-DL-D-FMK has been shown to activate HIV replication in infected T cells, such as ACH-2, making it valuable for studies in cell signaling and viral reactivation.
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  13. A25084
    Ac-AAVALLPAVLLALLAP-YVAD-CHO

    Caspase-1 Inhibitor

    Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1, a key enzyme involved in inflammatory processes and programmed cell death. This compound demonstrates significant antitumor activity by modulating inflammatory responses and apoptosis. It is suitable for research applications focused on understanding caspase-1's role in cancer biology and related inflammatory diseases.
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  14. A25086
    Ac-VEID-CHO

    Caspase Inhibitor

    Ac-VEID-CHO is a potent peptide-derived caspase inhibitor that targets Caspase-3, Caspase-6, and Caspase-7, displaying IC50 values of 13.6 nM, 16.2 nM, and 162.1 nM, respectively. Additionally, it inhibits VEIDase activity with an IC50 of 0.49 µM. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s and Huntington’s disease, facilitating the study of apoptotic pathways and potential therapeutic interventions.
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  15. A25100
    Ac-Trp-Glu-His-Asp-Aldehyde

    Caspase-1 Inhibitor

    Ac-Trp-Glu-His-Asp-Aldehyde is a selective inhibitor of caspase-1, demonstrating a remarkable Ki value of 56 pM. This compound plays a crucial role in the modulation of inflammatory processes by inhibiting the activation of caspase-1, an essential enzyme in the maturation of pro-inflammatory cytokines. It is widely utilized in research focused on innate immunity, inflammation, and therapeutic approaches for diseases driven by caspase-1 activity.
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  16. A25101
    Ac-VAD-CMK

    Caspase Inhibitor

    Ac-VAD-CMK is a pan-caspase inhibitor that effectively targets and inhibits various caspases, including caspases 1, 3, and 7. This compound is utilized in research to study apoptotic pathways and cell death mechanisms. Its application extends to investigating inflammation and neurodegenerative diseases where caspase activity is a critical factor.
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  17. A25105
    Ac-AAVALLPAVLLALLAP-LEHD-CHO

    Caspase 4/5/9 Inhibitor

    Ac-AAVALLPAVLLALLAP-LEHD-CHO is a potent inhibitor of caspases 4, 5, and 9. This compound demonstrates protective effects in MCF-7 cells treated with Neocarzinostatin, highlighting its potential applications in apoptosis research and cell survival studies. Its ability to modulate caspase activity makes it a valuable tool for investigating pathways related to cell death and disease mechanisms.
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  18. A25109
    Ac-VDVAD-CHO

    Caspase-2/3 Inhibitor

    Ac-VDVAD-CHO is a potent inhibitor of caspase-2 and caspase-3, with IC50 values of 46 nM and 15 nM, respectively. This compound effectively interferes with apoptotic signaling pathways, making it a valuable tool for research into cell death mechanisms. It is suitable for applications involving the study of apoptosis, neurodegeneration, and cancer.
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  19. A25111
    Ac-VAD-CHO

    Caspase Inhibitor

    Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor that specifically targets and inhibits caspase activity. This compound effectively prevents the dissipation of mitochondrial membrane potential (MMP) and the release of cytochrome c in cells exposed to hypoxic conditions. Ac-VAD-CHO is widely used in research applications aimed at studying apoptosis and cell survival mechanisms.
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  20. A25117
    Ac-LEHD-CHO

    Caspase Inhibitor

    Ac-LEHD-CHO is a selective inhibitor of caspase-8 and caspase-9. It effectively blocks apoptosis in hepatocytes and prevents hepatotoxicity induced by GalN/TNF-α. This compound is valuable for research applications involving cell death pathways and liver-related diseases.
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  21. A25146
    Ac-DMLD-CMK

    Caspase 3 Inhibitor, GSDME Inhibitor

    Ac-DMLD-CMK is a potent inhibitor of caspase 3 and GSDME, functioning by binding directly to the catalytic domain of caspase-3. This compound effectively obstructs caspase-3-mediated cleavage of GSDME, thereby modulating the caspase 3-GSDME signaling pathway. Its primary biological activity includes the reduction of pyroptosis and apoptosis, as well as the suppression of inflammatory cytokines such as LDH, IL-6, IL-1β, and IL-18. Ac-DMLD-CMK shows potential in mitigating renal function decline, renal tubular epithelial cell damage, and chemotherapeutic nephrotoxicity.
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  22. A25168
    CZL80

    Caspase-1 Inhibitor

    CZL80 is a potent caspase-1 inhibitor with an IC50 of 0.01 μM, capable of penetrating the blood-brain barrier. This compound is valuable for studying inflammatory pathways in neurological disorders, notably in the context of febrile seizures and their correlation with increased susceptibility to epilepsy. Research applications include investigating the role of caspase-1 in neuroinflammation and other brain-related pathologies.
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  23. A25194
    Ac-YVAD-FMK

    Caspase Like Protease Inhibitor

    Ac-YVAD-FMK is a selective inhibitor of caspase 1-like proteases. It functions by covalently modifying the active site cysteine, thus blocking the enzymatic activity of these proteases. This compound is valuable in the study of inflammation and cell death pathways, particularly in research focused on the mechanisms of pyroptosis and other caspase-associated processes.
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  24. A25197
    Z-LEED-FMK

    Caspase Inhibitor

    Z-LEED-FMK is a selective inhibitor of caspase-4 and caspase-13. This compound effectively inhibits the processing of caspase-1 in macrophages infected with S. typhimurium, making it a valuable tool for studying apoptosis and inflammatory pathways. Its specificity and inhibitory effects are significant for research applications in cell death mechanisms and inflammatory response investigations.
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  25. A25199
    Boc-AEVD-CHO

    Caspase 8 Inhibitor

    Boc-AEVD-CHO is a selective inhibitor of Caspase 8, a crucial enzyme involved in apoptotic pathways. This compound is valuable for investigating the mechanisms of apoptosis as well as the roles of Caspase 8 in various immune and inflammatory diseases. Researchers can utilize Boc-AEVD-CHO to better understand cellular processes related to programmed cell death and inflammation regulation.
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  26. A25207
    Cimiside E

    Caspase 3 Inhibitor

    Cimiside E, a caspase 3 inhibitor, is a triterpene xyloside known for its pro-apoptotic effects on gastric cancer cells, displaying an IC50 value of 14.58 μM. This compound induces cell cycle arrest in the G2/M phase and mediates apoptosis via activation of the caspase cascade across both extrinsic and intrinsic pathways. Cimiside E is a valuable tool in cancer research, particularly in studies focusing on apoptosis and cell cycle modulation.
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  27. A25209
    IETD-CHO

    Caspase-8 Inhibitor

    IETD-CHO is a selective inhibitor of caspase-8, a crucial enzyme in the apoptotic signaling pathway. By blocking caspase-8 activity, this reagent prevents the activation of downstream effector caspases, allowing for the study of programmed cell death mechanisms. IETD-CHO is widely used in research applications focused on apoptosis, inflammation, and related cell signaling processes.
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  28. A25271
    Caspase-9 Inhibitor III

    Caspase-9 Inhibitor

    Caspase-9 Inhibitor III (Ac-LEHD-cmk) targets and inhibits caspase-9, a critical component of the apoptotic pathway. This reagent demonstrates protective effects against ischemia-reperfusion-induced myocardial injury, making it valuable for studying cardiac apoptosis and related pathological conditions. It can be utilized in research focused on cellular survival mechanisms and the modulation of programmed cell death.
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  29. A25299
    Ac-FLTD-CMK

    Caspase Inhibitor

    Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases.
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  30. A25302
    Z-LEVD-FMK

    Caspase-4 inhibitor

    Z-LEVD-FMK is a cell-permeable inhibitor of caspase-4, a key player in the apoptotic signaling pathway. This reagent effectively blocks endoplasmic reticulum stress-induced apoptosis in cancer cells, making it a valuable tool for studying cell death mechanisms and developing therapeutic strategies in oncology research. Its specificity for caspase-4 facilitates investigations into its role in various cellular stress responses.
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  31. A25317
    Z-VAD-CHO

    Caspase Inhibitor

    Z-VAD-CHO is a potent, irreversible inhibitor of caspases, primarily targeting caspase-1 with a Ki value of 0.008 μM. This compound effectively modulates apoptotic pathways and is instrumental in studies related to inflammation and cell death. Z-VAD-CHO is widely utilized in research to investigate the role of caspases in various cellular processes and disease models.
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  32. A25319
    Z-YVAD-CMK

    Caspase-1/3 Inhibitor

    Z-YVAD-CMK is a potent inhibitor of caspase-1 and caspase-3, key enzymes involved in the apoptosis and inflammatory processes. By selectively blocking these caspases, Z-YVAD-CMK is invaluable for research applications focused on cell death pathways and inflammatory responses. It is particularly useful in studies investigating the role of caspases in disease models, including neurodegeneration and cancer.
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  33. A25320
    Berkeleyamide B

    MMP-3/Caspase-1 Inhibitor

    Berkeleyamide B is a dual inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1, targeting key enzymes involved in inflammation and tissue remodeling. This compound demonstrates significant biological activity in modulating apoptotic pathways and inflammatory responses. Berkeleyamide B is applicable in research focused on cancer and inflammatory diseases, including conditions such as rheumatoid arthritis.
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  34. A25321
    Caspase-3-IN-3

    Caspase-3 Inhibitor

    Caspase-3-IN-3 is a selective inhibitor of caspase-3, a crucial executioner enzyme in the apoptosis pathway. This compound has been shown to enhance cellular ATP levels, inhibit caspase-3 activity, and reduce nitrite production. Additionally, Caspase-3-IN-3 mitigates cytokine-induced apoptosis and restores insulin secretion stimulated by glucose, making it a valuable tool for research in apoptosis, metabolic disorders, and cellular energy regulation.
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  35. A25322
    Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone

    Caspase-3 Inhibitor

    Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a potent and cell-permeable inhibitor of caspase-3, acting through irreversible binding to the activated form in apoptotic cells. This reagent exhibits significant fluorescence, allowing for quantitative analysis via flow cytometry, microwell plate readers, or fluorescence microscopy. Its application is crucial for studying apoptosis and characterizing caspase-3 activity in various biological systems.
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  36. A25323
    VX-166

    Caspase Inhibitor

    VX-166 is a pan caspase inhibitor that modulates apoptosis by targeting caspase enzymes. This compound is instrumental in investigating Non-Alcoholic Fatty Liver Disease (NAFLD), nonalcoholic steatohepatitis (NASH), and alcoholic steatohepatitis (ASH), as well as other conditions characterized by liver fibrosis, steatosis, or inflammation. Its ability to inhibit caspase activity makes it a valuable tool for research in liver pathology and related diseases.
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  37. A25332
    CAY10406

    Caspase 3/7 Inhibitor

    CAY10406 is a selective inhibitor of caspase 3 and caspase 7. This compound effectively reduces the expression of the 28-kDa IL-1β fragment, making it useful for studies related to apoptosis and inflammatory processes. Notably, CAY10406 exhibits minimal cytotoxicity at concentrations up to 10 μM, allowing for safer applications in cellular assays.
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  38. A25336
    Berkeleyamide C

    MMP-3/Caspase-1 Inhibitor

    Berkeleyamide C is a selective inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1. This compound effectively blocks MMP-3-mediated tumor cell invasion and metastasis, while also inhibiting the abnormal activation of inflammation and apoptosis associated with caspase-1. Berkeleyamide C is valuable for research applications focused on cancer biology and inflammation-related diseases.
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  39. A25340
    ED11

    Caspase-6 Inhibitor

    ED11 is a selective inhibitor of caspase-6, demonstrating an IC50 of 12.12 nM. By competing with Huntingtin (Htt) for the active site of caspase-6, ED11 effectively reduces Htt cleavage. Notably, ED11 possesses the ability to cross the blood-brain barrier, making it a valuable reagent for research into Huntington's disease and related neurodegenerative disorders.
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  40. A25349
    Z-LEHD-FMK TFA

    Caspase-9 Inhibitor

    Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, primarily involved in the apoptosis pathway. This compound demonstrates significant neuroprotective effects, particularly in models of spinal cord injury, and has been shown to mitigate lethal reperfusion injury. It is a valuable tool for research focused on therapeutic strategies against apoptotic cell death and neuroprotection.
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  41. A25352
    Ac-DMQD-CHO

    Caspase Inhibitor

    Ac-DMQD-CHO is a selective inhibitor of caspase 3, exhibiting an IC50 of 39 nM. This compound effectively reduces apoptosis, making it a valuable tool in studies related to neuroprotection and cellular survival. Its application in research can aid in the exploration of therapeutic strategies targeting neurodegenerative diseases and apoptosis-related conditions.
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  42. A25353
    Z-LE(OMe)TD(OMe)-FMK

    Caspase-8 Inhibitor

    Z-LE(OMe)TD(OMe)-FMK is a selective inhibitor of caspase-8, a key enzyme involved in the apoptotic pathway. By inhibiting caspase-8 activity, this reagent effectively prevents apoptosis in various cell types, making it a valuable tool for studying cell survival mechanisms. It is widely used in research applications focused on programmed cell death and related signaling pathways.
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  43. A25357
    Ac-DMQD-AMC

    Caspase-3 Inhibitor

    Ac-DMQD-AMC is a selective inhibitor of caspase-3, a critical executioner caspase in the apoptosis pathway. This compound features an aromatic amine structure and is synthesized using the aminium-based coupling reagent HATU alongside 2,4,6-trimethylpyridine (TMP). Ac-DMQD-AMC is suitable for research applications focused on studying apoptosis, cellular signaling, and the role of caspases in various diseases.
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  44. A25361
    Ac-AAVALLPAVLLALLAP-DEVD-CHO

    Caspase-3 Inhibitor

    Ac-AAVALLPAVLLALLAP-DEVD-CHO is a specific and reversible inhibitor of caspase-3, a key executioner in the apoptotic pathway. This compound effectively reduces caspase-3 activity, making it a valuable tool for studying apoptosis and cell death mechanisms in various biological contexts. Its application extends to research on neurodegenerative diseases, cancer, and other conditions where caspase-3 plays a pivotal role in cellular regulation.
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  45. A25370
    Ac-AAVALLPAVLLALLAP-LEVD-CHO

    Caspase-4 Inhibitor

    Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4, a crucial mediator of inflammation and cell death pathways. This compound demonstrates notable antitumor activity, making it a valuable tool for studying caspase-related mechanisms in cancer research. Its ability to selectively inhibit caspase-4 can provide insights into therapeutic strategies aimed at mitigating inflammatory responses and promoting cell survival.
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  46. A25371
    Z-ATAD-FMK

    Caspase-12 Inhibitor

    Z-ATAD-FMK is a selective inhibitor of caspase-12, playing a crucial role in modulating apoptotic processes triggered by endoplasmic reticulum stress. By inhibiting caspase-12 activity, Z-ATAD-FMK effectively reduces downstream activation of caspase-9, thereby interfering with the apoptotic signaling pathways. This compound is valuable for research applications investigating the mechanisms of ER stress-induced apoptosis and cellular responses to stress.
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  47. A25376
    VRT-043198

    Caspase-1/4 Inhibitor

    VRT-043198 is a selective inhibitor of caspase-1 and caspase-4, functioning primarily as an interleukin-converting enzyme inhibitor. It demonstrates potent inhibition with Ki values of 0.8 nM for caspase-1 and 0.6 nM for caspase-4. This compound is capable of crossing the blood-brain barrier, making it valuable for research applications related to neuroinflammation and cytokine regulation.
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  48. A25387
    Caspase-3-IN-1

    Caspase-3 Inhibitor

    Caspase-3-IN-1 is a potent inhibitor of caspase-3, exhibiting an IC50 of 14.5 nM. This compound plays a crucial role in the modulation of apoptotic signaling pathways, making it valuable for research in cell death mechanisms and therapeutic applications in cancer and neurodegenerative diseases. Its high specificity and efficacy allow for detailed studies on caspase-3 activity and its implications in various biological processes.
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  49. A25389
    Penicillic acid

    Caspase Inhibitor

    Penicillic acid is a polyketide mycotoxin that serves as a caspase inhibitor. This compound demonstrates cytotoxic effects in rat alveolar macrophages, inhibiting Fas ligand-induced apoptosis through the blockade of caspase-8 self-processing. Its unique mechanism contributes to research in apoptosis and inflammation pathways, making it a valuable tool for studying cell death regulation in various biological contexts.
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  50. A25396
    M826

    Caspase-3 Inhibitor

    M826 is a selective, reversible non-peptide inhibitor of caspase-3, exhibiting an IC50 value of 0.005 μM. This compound demonstrates significant anti-apoptotic activity, both in vitro and in vivo, making it a valuable tool for studying apoptosis-related pathways. M826 is particularly relevant for research into nervous system diseases, offering potential insights into therapeutic strategies targeting apoptotic processes.
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