Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Azido-PEG10-Boc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its azide functional group enables efficient bioconjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG10-Boc can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating the development of targeted therapeutic agents in chemical biology research. -
PROTAC Linkers
Gly-PEG3-endo-BCN is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bicyclo[6.1.0]non-4-yne (BCN) moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Gly-PEG3-endo-BCN is essential for constructing bifunctional molecules, facilitating targeted protein degradation, and advancing chemical biology research applications. -
PROTAC Linker
Boc-methylglycine-C2-bromine is a PROTAC linker that facilitates the creation of targeted protein degradation molecules. This compound can be utilized in synthesizing PROTACs, such as the PROTAC SMARCA2 degrader-24, enabling selective degradation of specific proteins. Its application is significant in the exploration of targeted protein modulation for therapeutic development and biochemical research. -
PROTAC Linker
1-(Azetidin-3-yl)piperidine serves as a PROTAC (proteolysis-targeting chimera) linker, facilitating the design and synthesis of bifunctional molecules for targeted protein degradation. This compound plays a critical role in the development of innovative therapeutics by enhancing the delivery and specificity of these agents towards disease-associated proteins. Its application in chemical biology supports research in targeted protein modulation and therapeutic discovery. -
PROTAC Linkers
Thiol-PEG12-acid is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, promoting targeted protein degradation mechanisms via the ubiquitin-proteasome pathway. Its applications extend to drug discovery and molecular biology, making it a valuable tool in the development of novel therapeutics targeting disease-related proteins. -
PROTAC Linkers
Benzyl-PEG1-Tos is a PEG-based PROTAC linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the assembly of bifunctional molecules that can selectively target and degrade specific proteins within cells. It serves as a valuable tool in chemical biology research and drug development focused on targeted protein modulation. -
PROTAC Linker
Mal-C4-NH-Boc is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the creation of targeted protein degradation systems by connecting a ligand to an E3 ligase, thereby enabling the selective ubiquitination and subsequent proteasomal degradation of specific proteins. Mal-C4-NH-Boc is suitable for various applications in chemical biology and drug discovery, particularly in studies focused on targeted therapies and protein regulation. -
PROTAC Linker
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring a tetrazine moiety, this compound facilitates selective interactions through inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing partners. Its unique chemical structure allows for efficient conjugation and modularity in the design of targeted protein degradation experiments, making it a valuable tool in chemical biology and therapeutic development research. -
PROTAC Linker
endo-BCN-PEG2-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. Its application in PROTAC development allows for targeted protein degradation, making it a valuable tool in chemical biology and drug discovery. -
PROTAC Linkers
m-PEG16-COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, enabling the targeted degradation of specific proteins within cellular systems. It serves as a crucial component in the development of novel therapeutic agents aimed at modulating protein levels, making it valuable for research in cancer therapy and other diseases where protein degradation plays a key role. -
PROTAC Linker
Acid-PEG7-t-butyl ester is a polyethylene glycol (PEG)-derived linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs, enabling selective degradation of target proteins through the ubiquitin-proteasome system. Its hydrophilic properties enhance solubility and bioavailability, making it suitable for drug development and therapeutic research in targeted protein degradation strategies. -
PROTAC Linker
Nonylbenzene-PEG5-OH is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting moieties to E3 ligase binding domains, enhancing the degradation of specific proteins through the ubiquitin-proteasome system. Its unique structure allows for improved solubility and stability in biological systems, making it an essential tool for researchers investigating targeted protein modulation and degradation. -
PROTAC Linkers
m-PEG3-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase components, enabling targeted protein degradation. It is utilized in research applications focused on developing novel therapeutic strategies for controlling protein levels within cells. -
PROTAC Linker
1-Adamantane-amide-C7-NH2 is a PROTAC linker designed to facilitate the synthesis of targeted protein degraders. This compound plays a crucial role in the development of novel therapeutics by enabling the selective degradation of specific proteins, such as the GPX4 degrader-3. It is utilized in research applications aimed at exploring protein homeostasis and targeted protein degradation mechanisms. -
PROTAC Linker
C6-Bis-phosphoramidic acid diethyl ester is a versatile linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs by enabling the conjugation of protein ligands to E3 ligase recruiters, promoting the targeted degradation of specific proteins. Its application is crucial in the field of targeted protein degradation research, aiding in the development of novel therapeutic strategies. -
PROTAC linker
N-methyl-N'-(azide-PEG3)-Cy3 is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound acts as a click chemistry reagent due to the presence of an azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology and medicinal chemistry research applications. -
PROTAC Linker
Aminooxy-PEG4-acid is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of binding moieties to E3 ligases, thereby enabling targeted protein degradation. Its application in PROTAC development supports advancements in targeted therapies and drug discovery efforts by improving the efficacy and specificity of protein modulation. -
PROTAC Linker
Mal-amido-PEG3-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a maleimide functionality, allowing for specific conjugation to thiol-containing target proteins. Its versatility facilitates the development of PROTACs for targeted protein degradation, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
3-Azaspiro[5.5]undecane-9-methanol serves as an effective PROTAC linker, facilitating the development of targeted protein degraders. This compound is integral in synthesizing novel degraders, such as CW-3308, and supports research in protein regulation and degradation pathways. Its unique structural features and functionality make it a valuable tool for advancing studies in targeted therapeutics and drug discovery. -
PROTAC Linker
Benzyloxy-C5-PEG1 is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It enables the efficient recruitment of E3 ubiquitin ligases, facilitating targeted protein degradation. This compound is essential for researchers developing innovative strategies in targeted therapeutics and cellular biology studies. -
PROTAC Linkers
Hydroxy-PEG8-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the selective degradation of target proteins through the ubiquitin-proteasome pathway. Its extended PEG structure enhances solubility and biocompatibility, making it suitable for the synthesis of various PROTACs in chemical biology research. -
PROTAC Linker
Br-Boc-C2-azido is a specialized PROTAC linker featuring an azide group that facilitates the synthesis of PROTACs through click chemistry. This compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynes and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified molecules. Its versatile reactivity makes it a valuable tool for researchers in the development of targeted protein degradation technologies. -
PROTAC Linkers
Tos-PEG9 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This versatile linker facilitates the conjugation of target proteins to E3 ligases, enhancing the mechanisms of targeted protein degradation. Tos-PEG9 is suitable for applications in drug discovery, particularly for researching the modulation of protein levels in various biological pathways. -
PROTAC linker
N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through the azide group. This compound participates in click chemistry, specifically through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It is also capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized entities, making it a versatile tool for targeted protein degradation studies and other bioconjugation applications. -
PROTAC Linker
Azido-PEG8-Boc is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimera (PROTAC) compounds. Featuring an azide functional group, it enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-bearing and DBCO or BCN-modified molecules, respectively. This compound is essential for researchers investigating targeted protein degradation pathways and advancing drug discovery in various therapeutic areas. -
PROTAC Linkers
DBCO-PEG12-acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of Proteolysis Targeting Chimera (PROTAC) molecules. Featuring a DBCO ( dibenzocyclooctyne) moiety, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is integral for developing novel bifunctional agents aimed at targeted protein degradation, enhancing research in pharmacology and therapeutic applications. -
PROTAC Linkers
Ms-PEG6-THP is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its flexible structure enhances the stability and efficiency of target protein degradation. This compound is essential for researchers exploring targeted protein removal strategies in drug discovery and development. -
PROTAC Linkers
N-(Azido-PEG3)-NH-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. It features an azide functional group that facilitates click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for conjugating various biomolecules in chemical biology research. -
PROTAC Linkers
Bromo-PEG4-MS is a PEG-based PROTAC linker that facilitates the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound is integral in enhancing the cellular degradation of target proteins through targeted ubiquitination. Its application in research supports the development of novel therapeutic strategies aimed at regulating protein levels in various disease models. -
PROTAC Linkers
THP-PEG8-Tos is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation and modulation of protein levels within cells. THP-PEG8-Tos is essential for research applications focused on targeted protein degradation and therapeutic development in various disease contexts. -
PROTAC Linker
HS-PEG5-CH2CH2N3 serves as a PEG-based PROTAC linker and primarily targets the synthesis of PROTACs. This compound is a versatile click chemistry reagent featuring an azide functional group that participates in copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition reactions with molecules containing DBCO or BCN groups, facilitating efficient conjugation and molecular assembly in chemical biology applications. -
PROTAC Linker
Bromo-PEG2-acetic acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. Its bromo functional group facilitates conjugation with target proteins, enabling the formation of effective proteolytic degraders. This reagent is essential for researchers focusing on targeted protein degradation and modulation of cellular pathways. -
PROTAC Linker
Biotin-PEG3-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a biotin moiety that facilitates selective protein targeting and degradation, making it a valuable tool in chemical biology research. Its use in PROTAC development enables the study of targeted protein modulation and offers potential applications in therapeutic intervention. -
PROTAC Linker
Mal-NH-PEG4-CH2CH2COOPFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of proteins by linking two distinct warheads, enabling the selective modulation of protein levels in biological systems. Its solubility and flexibility enhance the efficacy of PROTAC constructs, making it a valuable tool in chemical biology and drug development research. -
PROTAC Linkers
N-(Azido-PEG4)-N-bis(PEG4-NHS ester) is a poly(ethylene glycol)-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds, making it a versatile tool for researchers in chemical biology and drug development. -
PROTAC Linker
Boc-PEG4-methyl propionate is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and bioavailability of PROTACs, contributing to their efficacy in targeted protein degradation. It is particularly useful for researchers developing novel therapeutics in cancer treatment and disease modulation through targeted protein control. -
PROTAC Linker
Azido-PEG3-C-Boc is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, facilitating efficient conjugation in chemical biology applications. This reagent is suitable for researchers investigating targeted protein degradation mechanisms and advancing drug discovery efforts. -
PROTAC Linkers
Tos-PEG2-THP is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This reagent facilitates the conjugation of target proteins and E3 ubiquitin ligases, enabling targeted protein degradation. Its unique structure enhances solubility and molecular recognition, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
Boc-Aminooxy-PEG3-C2-NH2 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to target proteins, enabling their ubiquitination and subsequent degradation. Its unique structure enhances solubility and promotes effective conjugation, making it suitable for studies in targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
Azido-PEG3-amide-C3-triethoxysilane is a PEG-based linker designed for use in the synthesis of PROTACs, specifically targeting protein degradation pathways. This compound features an azide functional group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified entities, making it a versatile tool for chemical biology applications in the development of targeted protein modulators. -
PROTAC Linkers
N-Boc-C1-PEG5-C3-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cells. Its unique structure enhances solubility and biocompatibility, making it a valuable tool for researchers studying targeted protein degradation and related pathways. -
PROTAC Linker
Azide-PEG5-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily as a click chemistry reagent. Its azide group enables efficient copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing compounds, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized molecules. This versatility makes Azide-PEG5-Boc a valuable tool in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Dimethylamino-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by enhancing solubility and improving pharmacokinetic properties. Dimethylamino-PEG3 is essential for researchers exploring targeted protein degradation mechanisms and therapeutic applications in cancer and other diseases. Its utility in PROTAC chemistry makes it a valuable tool for advancing drug discovery efforts. -
PROTAC Linker
Thiol-PEG3-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a thiol group allowing for stable conjugation to target proteins, enhancing the development of targeted protein degradation strategies. This compound is essential in research applications focused on drug discovery and development, particularly in the modulation of protein levels within cellular systems. -
PROTAC Linkers
NH-bis(PEG3-C2-NH-Boc) is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and bioavailability of PROTACs, thereby improving their efficacy in targeted degradation of specific proteins. NH-bis(PEG3-C2-NH-Boc) is utilized in biochemical research to explore protein function and therapeutic applications in diseases linked to protein dysregulation. -
PROTAC Linkers
Amino-PEG36-acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic spacer, which enhances the stability and solubility of the final construct. Its primary application lies in the development of targeted protein degradation strategies for both therapeutic and research purposes, enabling the selective modulation of protein levels in various biological systems. -
PROTAC Linkers
MS-PEG3-THP is a polyethylene glycol (PEG) based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the creation of PROTACs by providing a flexible and biocompatible linkage, effectively enhancing their solubility and stability. MS-PEG3-THP is suitable for applications in targeted protein degradation research and the development of therapeutic agents aimed at modulating specific protein functions within cellular pathways. -
PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG3-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, with a primary mechanism involving click chemistry. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, enhancing its utility in diverse chemical biology applications. The compound provides a versatile tool for researchers in drug development and targeted protein degradation studies. -
PROTAC Linkers
m-PEG3-Sulfone-PEG3 is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target proteins with E3 ligases, promoting the targeted degradation of specific proteins within cellular systems. It is widely utilized in therapeutic research and drug development to explore protein degradation mechanisms and enhance the efficacy of targeted therapies. -
PROTAC linker
N-Boc-N-bis(C2-PEG1-azide) is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) when paired with alkyne-containing moieties. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, providing versatile coupling options for bioconjugation and targeting studies in chemical biology.
