Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
3-(2-Pyridyldithio)propanoic Acid serves as an alkyl chain-based linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the targeted degradation of proteins by bringing together an E3 ligase and a protein of interest, promoting ubiquitination and subsequent proteasomal degradation. Its unique structure and reactivity allow for enhanced stability and efficacy in various research applications involving targeted protein degradation. -
PROTAC Linkers
m-PEG1-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligands to E3 ligase while enhancing solubility and bioavailability. It is an essential reagent for researchers developing targeted protein degradation strategies and studying cellular pathways through the modulation of specific protein levels. -
PROTAC Linkers
TCO-PEG2-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, making it a valuable tool for chemical biology research. Its flexibility and solubility contribute to improved efficacy in the development of innovative therapeutic strategies targeting various diseases. -
PROTAC Linker
BCN-exo-PEG3-NH2 is a PEG-based linker designed for PROTAC (PROteolysis-TArgeting Chimeras) synthesis. This compound features a BCN (bicyclononyne) group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for applications in targeted protein degradation research, enabling precise modulation of protein levels within biological systems. -
PROTAC Linkers
Biotin-PEG2-CH2CH2N3 is a PEG-based linker designed for PROTAC synthesis, targeting protein degradation pathways. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN-tagged compounds, making it versatile for diverse chemical biology applications, including targeted protein degradation studies. -
PROTAC Linker
Boc-NH-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic spacer that connects the target ligand and E3 ligase components. Its primary application lies in advancing research in targeted protein degradation, enabling the selective modulation of protein levels within cells. -
PROTAC Linkers
Biotin-PEG12-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of proteins through biotinylation, enhancing the pharmacokinetic properties of PROTACs. Its unique structure allows for improved solubility and stability, making it a valuable tool in targeted protein degradation research and drug discovery applications. -
PROTACT linker
2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid serves as a PROTACT linker, facilitating the targeted protein degradation of SMARCA2 and SMARCA4. This compound enhances the specificity and efficacy of proteolysis-targeting chimeras (PROTACs) by promoting the interaction between ligands and E3 ubiquitin ligases. It is an essential tool for researchers investigating protein homeostasis and therapeutic strategies in various biological contexts. -
PROTAC Linker
Boc-NH-PEG12-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target protein ligands to E3 ligase recruiters, enhancing the effectiveness of PROTACs in promoting targeted protein degradation. It is a valuable tool for researchers investigating novel therapeutic strategies through the modulation of protein homeostasis. -
PROTAC Linker
2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras. This compound effectively engages with E3 ligases, promoting targeted protein degradation. Its application is pivotal in the design and synthesis of hybrid molecules for research in drug discovery and therapeutic development. -
PROTAC Linker
2-(Bromomethyl)-1,3-dioxolane is a chemical linker specifically designed for use in synthesizing PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that can selectively induce the degradation of target proteins through the ubiquitin-proteasome system. Its utility in the development of targeted protein degradation strategies makes it valuable for research in drug discovery and therapeutic applications. -
PROTAC Linker
tert-Butyl 8-aminooctanoate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. Its structure enables optimal interaction with target proteins, enhancing the overall efficacy of targeted protein degradation assays. This reagent is essential for researchers focused on investigating novel therapeutic strategies involving proteolysis-targeting chimeras. -
PROTAC Linkers
mPEG45-Epoxide is a polyethylene glycol (PEG) derivative featuring polyether units, designed for use as a linker in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, enabling targeted protein degradation. mPEG45-Epoxide is instrumental in the development of novel therapeutic agents and in studying protein regulation mechanisms within cellular environments. -
PROTAC Linker
4-Boc-aminomethyl-piperidine is a versatile PROTAC linker that facilitates the development of targeted protein degradation therapies. This compound is essential for synthesizing various PROTACs, enabling the selective degradation of specific proteins within cellular pathways. Its application in research helps to advance therapeutic strategies for diseases driven by protein misregulation. -
PROTAC Linker
trans-4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexaneacetic acid acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is instrumental in the synthesis of PROTACs, which harness the cell's ubiquitin-proteasome system for targeted protein degradation. Its unique structure enhances the activity and specificity of PROTACs in various research applications, making it a critical reagent for studies in targeted therapy and protein modulation. -
PROTAC Linker
(E)-tert-Butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl)oxy)silane serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins via the ubiquitin-proteasome system and is instrumental in drug discovery and development. Its unique structure allows for effective conjugation, enhancing cellular permeability and targeting specificity in therapeutic applications. -
PROTAC Linker
tert-Butyl (7-azaspiro[3.5]nonan-2-yl)carbamate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This compound enhances the targeted degradation of specific proteins through the ubiquitin-proteasome system, promoting effective protein removal. Its unique structural features support the development of novel therapeutic agents for research in targeted protein degradation. -
PROTAC Linker
tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins, enhancing cellular studies in target validation and therapeutic development. Its structural properties make it suitable for a variety of research applications in chemical biology and drug discovery. -
PROTAC Linker
tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate serves as a link for PROTAC (proteolysis-targeting chimera) synthesis, facilitating the creation of bifunctional molecules that can selectively target specific proteins for degradation. This compound is instrumental in the field of targeted protein degradation research, enabling the development of novel therapeutics that can modulate protein levels in a controlled manner. -
PROTAC Linker
tert-Butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds between target proteins and E3 ligases, thus enhancing the ubiquitin-proteasome degradation pathway. Its effectiveness in linking various pharmacophores makes it a valuable tool for researchers exploring targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its structure allows for effective conjugation with various target proteins and E3 ligases, enabling the selective degradation of specific intracellular proteins. This reagent is essential for researchers aiming to explore targeted protein degradation mechanisms and develop innovative therapeutic strategies. -
PROTAC Linkers
N-(Azido-PEG3)-N-bis(PEG4-Boc) serves as a versatile PEG-based linker for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. Its azide group enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, while also facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent is an effective tool in the design of targeted protein degradation strategies, promoting advancements in cellular and molecular biology research. -
PROTAC Linkers
Cbz-PEG5-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its structure facilitates the conjugation of target ligands to E3 ligase recruiters, enhancing the development of bifunctional compounds that promote targeted protein degradation. This reagent is essential for researchers focusing on the modulation of protein levels in various biological pathways. -
PROTAC Linker
5-(Biotinamido)pentylazide is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynes. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a valuable tool for chemical research in targeted protein degradation and related applications. -
PROTAC Linker
Mal-amido-PEG7-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its amide group facilitates the conjugation of partners targeting specific proteins for ubiquitin-mediated degradation. This linker enhances the solubility and biocompatibility of PROTAC compounds, making it valuable in drug discovery and therapeutic development targeting protein homeostasis. -
PROTAC Linkers
m-PEG3-OMs is a polyethylene glycol (PEG)-based linker specifically designed for the construction of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase-recruiting components to target proteins, enabling selective degradation through the ubiquitin-proteasome pathway. It is widely utilized in drug discovery and development research focused on targeted protein degradation. -
PROTAC Linker
Boc-NH-PEG7-Tos is a polyethylene glycol (PEG) based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This linker enhances the solubility and bioavailability of PROTAC compounds, improving their stability and efficacy in biological systems. It serves as a valuable tool for researchers exploring targeted protein degradation pathways and developing novel therapeutic strategies in drug discovery. -
PROTAC Linkers
Acid-C1-PEG5-Boc is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of effective degraders by connecting a target protein ligand with an E3 ligase ligand, enhancing cellular proteolysis of target proteins. Its versatility makes it suitable for various applications in chemical biology and drug development, particularly in studies aimed at targeted protein degradation. -
PROTAC Linkers
m-PEG8-azide is a PEG-based linker specifically designed for PROTAC synthesis. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, m-PEG8-azide is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) when used with DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for researchers engaged in targeted protein degradation studies. -
PROTAC Linkers
Tos-PEG4-CH2COOH is a PEG-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its structural properties facilitate the formation of PROTACs that can effectively target specific proteins for selective degradation. This compound is integral to research applications focused on protein modulation and targeted protein degradation strategies in drug discovery and development. -
PROTAC Linker
Bis-PEG2-Boc is a polyethylene glycol-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the assembly of bifunctional molecules to promote targeted protein degradation, enabling the efficient study of protein function and regulation. This reagent is essential for researchers exploring innovative therapeutic approaches in drug discovery and development. -
PROTAC Linker
Bis-propargyl-PEG9 is a PEG-based linker designed for the synthesis of PROTACs, facilitating the development of targeted protein degradation strategies. This compound enables the construction of bivalent ligands, particularly for estrogen receptors, enhancing the efficacy of cellular target engagement. As a click chemistry reagent containing an alkyne group, Bis-propargyl-PEG9 is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Biotin-PEG6-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the efficient conjugation of biotin to target proteins, facilitating selective degradation via the ubiquitin-proteasome pathway. Its application in PROTAC development supports research in targeted protein degradation and therapeutic intervention in various diseases. -
PROTAC Linker
5-[Boc(methyl)amino]pentanal is a bifunctional linker designed for use in the synthesis of PROTACs. This compound features an alkyl amine structure that facilitates robust target protein degradation through the ubiquitin-proteasome system. It is ideal for applications in chemical biology research focused on targeted protein modulation and therapeutic development. -
PROTAC Linker
NHS-PEG4-(m-PEG4)3-ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between targeting ligands and E3 ligase recruiters, enhancing the development of targeted protein degradation strategies. Its application is significant in chemical biology research, particularly in studies aimed at modulating protein levels within cells. -
PROTAC Linkers
Acid-PEG25-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by optimizing the conjugation of various protein tags and ligands. Its use is pivotal in research applications aimed at exploring novel therapeutic strategies through protein modulation and degradation pathways. -
PROTAC Linkers
m-PEG4-sulfonic acid functions as a PEG-based linker for the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands and E3 ligases, enhancing the cellular delivery and degradation of specific protein targets. It is particularly valuable for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
Azide-PEG3-C1-Ala is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatile linker is essential for studying targeted protein degradation and enhancing the efficacy of therapeutic agents. -
PROTAC Linker
Bis-PEG7-PFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that target specific proteins for degradation, thereby enabling the selective modulation of protein levels within cellular systems. Its unique structure enhances solubility and biocompatibility, making it suitable for various research applications in chemical biology and therapeutic development. -
PROTAC Linkers
Bis-Mal-PEG6 is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This bifunctional molecule facilitates the conjugation of ligands to E3 ligases, enabling targeted degradation of proteins within cells. Its application in PROTAC development supports research in areas such as targeted protein degradation and therapeutic development. -
PROTAC Linkers
MS-PEG12-THP is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the efficient conjugation of target proteins to E3 ubiquitin ligases, thereby enhancing the degradation of specific proteins in cellular contexts. Its applications include drug development and the study of targeted protein degradation mechanisms, making it a valuable tool in chemical biology and therapeutic research. -
PROTAC Linkers
PEG4-MS is a polyethylene glycol (PEG) based linker designed specifically for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the formation of covalent bonds, enhancing the stability and solubility of the resultant PROTAC molecules. PEG4-MS plays a crucial role in targeted protein degradation studies and drug discovery research, aiding in the development of novel therapeutic agents. -
PROTAC Linkers
N-Boc-piperazine-C3-COOH is a chemical linker utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds, specifically designed for target protein degradation. This compound facilitates the assembly of bifunctional molecules that engage and ubiquitinate target proteins, promoting their degradation via the proteasome. Its application is significant in research focused on modulating immune checkpoints such as PD-1/PD-L1 through PROTAC PD-1/PD-L1 degrader-1 development. -
PROTAC Linker
N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononynes (BCN), making it a versatile tool for bioconjugation and targeted protein degradation studies. -
PROTAC linker
Boc-piperazine-C13-OTs is a versatile PROTAC linker designed for facilitating targeted protein degradation. This compound enables the construction of bifunctional molecules that can selectively degrade specific proteins, thereby offering significant potential in therapeutic applications. It is particularly useful in the synthesis of NC-R17 for various biochemical and cellular studies in the field of drug discovery and development. -
PROTAC Linkers
N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a PEG-based linker designed for use in the synthesis of PROTAC (PROteolysis TArgeting Chimeras) molecules. This compound facilitates the conjugation of target proteins to E3 ligases, promoting the ubiquitination and degradation of specific proteins. Its application in research enhances the development of targeted protein degradation strategies in cellular studies and drug discovery. -
PROTAC Linker
N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker featuring a terminal azide group. This unique compound enables the synthesis of PROTACs and serves as a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups, making it a valuable tool for chemical biology research and therapeutic development. -
PROTAC Linker
Amino-PEG8-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism targets the recruitment of E3 ubiquitin ligases, facilitating the ubiquitination and degradation of specific proteins. This reagent is essential for developing novel therapeutic strategies aimed at modulating protein levels and has significant applications in chemical biology and drug discovery research. -
PROTAC Linkers
Tos-PEG2-CH2-Boc is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of molecular conjugates that can effectively engage specific target proteins for degradation via the ubiquitin-proteasome system. It is essential for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies in drug discovery. -
PROTAC Linkers
Bis-PEG17-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating their application in targeted protein degradation research. It is suitable for studies aiming to modulate specific protein levels within cellular systems, contributing to advancements in drug discovery and therapeutic development.
