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N-(Azido-PEG3)-N-bis(PEG4-Boc)

PROTAC Linkers

N-(Azido-PEG3)-N-bis(PEG4-Boc) serves as a versatile PEG-based linker for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. Its azide group enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, while also facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent is an effective tool in the design of targeted protein degradation strategies, promoting advancements in cellular and molecular biology research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2353409-58-0
Applications	PROTAC Linkers
Formula	C₃₈H₇₄N₄O₁₅
Molecular Weight	827.01
SMILES	[N-]=[N+]=NCCOCCOCCOCCN(CCOCCOCCOCCOCCC(OC(C)(C)C)=O)CCOCCOCCOCCOCCC(OC(C)(C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.