Bis-propargyl-PEG9 is a PEG-based linker designed for the synthesis of PROTACs, facilitating the development of targeted protein degradation strategies. This compound enables the construction of bivalent ligands, particularly for estrogen receptors, enhancing the efficacy of cellular target engagement. As a click chemistry reagent containing an alkyne group, Bis-propargyl-PEG9 is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in chemical biology and drug discovery applications.
Bis-propargyl-PEG9 is a PEG-based linker designed for the synthesis of PROTACs, facilitating the development of targeted protein degradation strategies. This compound enables the construction of bivalent ligands, particularly for estrogen receptors, enhancing the efficacy of cellular target engagement. As a click chemistry reagent containing an alkyne group, Bis-propargyl-PEG9 is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in chemical biology and drug discovery applications.
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