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Caspase

Items 1-50 of 147

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Catalog No.
Product Name
Application
Product Information
Citations
  1. A14915
    Q-VD-OPh

    Caspase inhibitor

    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
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  2. A16317
    Z-YVAD-FMK

    Caspase-1 inhibitor

    Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
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  3. A11090
    PAC-1

    Caspase activator

    PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
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  4. A12697
    Z-DQMD-FMK

    Caspase-3 inhibitor

    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
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  5. A12800
    Z-IETD-FMK

    caspase 8 inhibitor

    Z-IETD-FMK is a specific inhibitor of caspase 8.
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  6. A14358
    Z-LEHD-FMK

    Caspase-9 Inhibitor

    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
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  7. A13652
    AVN-944

    IMPDH inhibitor

    AVN-944 (also known as VX-944) serves as an effective oral inhibitor, specifically targeting and inhibiting IMPDH (inosine monophosphate dehydrogenase). This enzyme plays a crucial role as a rate-limiting factor in the synthesis of guanine nucleotides from scratch. Additionally, AVN-944 acts against the synthesis of RNA in arenaviruses, effectively preventing arenavirus infections. Demonstrating a wide spectrum of anti-cancer properties, AVN-944 is utilized in research related to multiple myeloma (MM) and acute myeloid leukemia (AML).

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  8. A13503
    Z-DEVD-FMK

    Caspase-3 Inhibitor

    Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
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  9. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  10. A14100
    Nivocasan (GS-9450)

    Caspase inhibitor

    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
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  11. A10984
    VX-765 (Belnacasan)

    Caspase-1/4 inhibitor

    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
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  12. A13070
    LY573636 (Tasisulam)

    Apoptosis inducer

    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
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  13. A15300
    Ivachtin

    Caspase-3 inhibitor

    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
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  14. A21557
    ML132

    caspase 1 inhibitor

    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM.
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  15. A22408
    5,7,4'-Trimethoxyflavone

    anticancer agent

    5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner.
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  16. A21147
    Phenoxodiol
    Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis.
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  17. A23146
    Ac-YVAD-pNA

    Caspase-1 substrate

    Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes.
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  18. A25077
    Z-VA-DL-D-FMK

    Caspase Inhibitor

    Z-VA-DL-D-FMK is an irreversible caspase inhibitor that targets and binds to caspases, modulating their activity. This compound enhances the sensitivity of TNF-α, thereby influencing apoptotic pathways. Additionally, Z-VA-DL-D-FMK has been shown to activate HIV replication in infected T cells, such as ACH-2, making it valuable for studies in cell signaling and viral reactivation.
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  19. A25084
    Ac-AAVALLPAVLLALLAP-YVAD-CHO

    Caspase-1 Inhibitor

    Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1, a key enzyme involved in inflammatory processes and programmed cell death. This compound demonstrates significant antitumor activity by modulating inflammatory responses and apoptosis. It is suitable for research applications focused on understanding caspase-1's role in cancer biology and related inflammatory diseases.
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  20. A25085
    Cosdosiran

    Caspase 2 siRNA

    Cosdosiran is a chemically modified small interfering RNA (siRNA) that specifically targets and inhibits the expression of caspase 2 protein. This reagent is instrumental in researching nonarteritic anterior ischemic optic neuropathy and various optic neuropathies, including glaucoma, that lead to the degeneration of retinal ganglion cells. Cosdosiran facilitates the exploration of pathways involved in retinal cell survival and offers insights into potential therapeutic strategies for neurodegenerative eye diseases.
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  21. A25086
    Ac-VEID-CHO

    Caspase Inhibitor

    Ac-VEID-CHO is a potent peptide-derived caspase inhibitor that targets Caspase-3, Caspase-6, and Caspase-7, displaying IC50 values of 13.6 nM, 16.2 nM, and 162.1 nM, respectively. Additionally, it inhibits VEIDase activity with an IC50 of 0.49 µM. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s and Huntington’s disease, facilitating the study of apoptotic pathways and potential therapeutic interventions.
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  22. A25100
    Ac-Trp-Glu-His-Asp-Aldehyde

    Caspase-1 Inhibitor

    Ac-Trp-Glu-His-Asp-Aldehyde is a selective inhibitor of caspase-1, demonstrating a remarkable Ki value of 56 pM. This compound plays a crucial role in the modulation of inflammatory processes by inhibiting the activation of caspase-1, an essential enzyme in the maturation of pro-inflammatory cytokines. It is widely utilized in research focused on innate immunity, inflammation, and therapeutic approaches for diseases driven by caspase-1 activity.
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  23. A25101
    Ac-VAD-CMK

    Caspase Inhibitor

    Ac-VAD-CMK is a pan-caspase inhibitor that effectively targets and inhibits various caspases, including caspases 1, 3, and 7. This compound is utilized in research to study apoptotic pathways and cell death mechanisms. Its application extends to investigating inflammation and neurodegenerative diseases where caspase activity is a critical factor.
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  24. A25105
    Ac-AAVALLPAVLLALLAP-LEHD-CHO

    Caspase 4/5/9 Inhibitor

    Ac-AAVALLPAVLLALLAP-LEHD-CHO is a potent inhibitor of caspases 4, 5, and 9. This compound demonstrates protective effects in MCF-7 cells treated with Neocarzinostatin, highlighting its potential applications in apoptosis research and cell survival studies. Its ability to modulate caspase activity makes it a valuable tool for investigating pathways related to cell death and disease mechanisms.
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  25. A25109
    Ac-VDVAD-CHO

    Caspase-2/3 Inhibitor

    Ac-VDVAD-CHO is a potent inhibitor of caspase-2 and caspase-3, with IC50 values of 46 nM and 15 nM, respectively. This compound effectively interferes with apoptotic signaling pathways, making it a valuable tool for research into cell death mechanisms. It is suitable for applications involving the study of apoptosis, neurodegeneration, and cancer.
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  26. A25111
    Ac-VAD-CHO

    Caspase Inhibitor

    Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor that specifically targets and inhibits caspase activity. This compound effectively prevents the dissipation of mitochondrial membrane potential (MMP) and the release of cytochrome c in cells exposed to hypoxic conditions. Ac-VAD-CHO is widely used in research applications aimed at studying apoptosis and cell survival mechanisms.
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  27. A25113
    Ac-LEVDGWK(Dnp)-NH2

    Caspase-3 Substrate

    Ac-LEVDGWK(Dnp)-NH2 is a synthetic substrate for Caspase-3, designed to facilitate the measurement of Caspase-3 enzymatic activity. Its use in research enables the study of apoptosis and cellular signaling pathways, providing insights into the role of Caspase-3 in various biological processes. This substrate can be employed in assays to quantify Caspase-3 activity in different biological samples.
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  28. A25114
    Z-VAD-AMC

    Caspase-9 Substrate

    Z-VAD-AMC is a potent substrate for caspase-9, facilitating the study of apoptosis mechanisms. It exhibits high specificity for this caspase, enabling accurate monitoring of caspase activity in cellular assays. Researchers commonly utilize Z-VAD-AMC in studies focusing on programmed cell death, cellular stress responses, and therapeutic interventions targeting apoptotic pathways.
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  29. A25117
    Ac-LEHD-CHO

    Caspase Inhibitor

    Ac-LEHD-CHO is a selective inhibitor of caspase-8 and caspase-9. It effectively blocks apoptosis in hepatocytes and prevents hepatotoxicity induced by GalN/TNF-α. This compound is valuable for research applications involving cell death pathways and liver-related diseases.
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  30. A25127
    (Asp)2-Rhodamine 110

    Caspase Substrate

    (Asp)2-Rhodamine 110 is a fluorescent substrate specifically designed for caspase activity detection. This compound is cleaved by active caspases, resulting in the release of a fluorescent signal that allows for real-time monitoring of apoptosis in various biological systems. It is widely utilized in research applications focused on cell death mechanisms and therapeutic interventions targeting apoptosis.
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  31. A25129
    Ac-VDVAD-pNA

    Caspase-2 Substrate

    Ac-VDVAD-pNA is a specific substrate for caspase-2, designed to facilitate the assessment of caspase-2 activity in various biological samples. This reagent releases a chromogenic product upon cleavage by active caspase-2, making it useful for both in vitro and in vivo studies. It serves as a vital tool in research applications focused on apoptotic pathways and caspase-related signaling mechanisms.
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  32. A25146
    Ac-DMLD-CMK

    Caspase 3 Inhibitor, GSDME Inhibitor

    Ac-DMLD-CMK is a potent inhibitor of caspase 3 and GSDME, functioning by binding directly to the catalytic domain of caspase-3. This compound effectively obstructs caspase-3-mediated cleavage of GSDME, thereby modulating the caspase 3-GSDME signaling pathway. Its primary biological activity includes the reduction of pyroptosis and apoptosis, as well as the suppression of inflammatory cytokines such as LDH, IL-6, IL-1β, and IL-18. Ac-DMLD-CMK shows potential in mitigating renal function decline, renal tubular epithelial cell damage, and chemotherapeutic nephrotoxicity.
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  33. A25164
    KEA1-97

    Thioredoxin-Caspase 3 Disruptor

    KEA1-97 is a selective disruptor of the thioredoxin-caspase 3 interaction, exhibiting an IC50 of 10 μM. This compound effectively disrupts the binding of thioredoxin to caspase 3, leading to the activation of caspases and subsequent induction of apoptosis, while preserving thioredoxin's enzymatic function. KEA1-97 is valuable for research into apoptosis mechanisms and therapeutic strategies targeting cell death pathways.
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  34. A25168
    CZL80

    Caspase-1 Inhibitor

    CZL80 is a potent caspase-1 inhibitor with an IC50 of 0.01 μM, capable of penetrating the blood-brain barrier. This compound is valuable for studying inflammatory pathways in neurological disorders, notably in the context of febrile seizures and their correlation with increased susceptibility to epilepsy. Research applications include investigating the role of caspase-1 in neuroinflammation and other brain-related pathologies.
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  35. A25173
    Ac-Trp-Glu-His-Asp-AMC

    Caspase-1 Fluorogenic Substrate

    Ac-Trp-Glu-His-Asp-AMC is a specific fluorogenic substrate designed for caspase-1 detection and activity measurement. This compound exhibits high sensitivity and selectivity for caspase-1, enabling the quantitative assessment of apoptotic processes and inflammatory pathways. Its application in fluorescence assays facilitates the study of caspase-1's role in various biological contexts, including immune responses and cell death mechanisms.
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  36. A25188
    Z-IETD-pNA

    Granzyme B/Caspase-8 Substrate

    Z-IETD-pNA is a specific substrate for caspase-8 and granzyme B, designed for colorimetric detection. Upon hydrolysis by caspase-8, this compound releases para-nitroaniline (pNA), facilitating the measurement of enzyme activity. It is widely utilized in research applications focusing on apoptosis and immune responses, enabling the study of cell death mechanisms and the role of granzyme B in cytotoxicity.
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  37. A25194
    Ac-YVAD-FMK

    Caspase Like Protease Inhibitor

    Ac-YVAD-FMK is a selective inhibitor of caspase 1-like proteases. It functions by covalently modifying the active site cysteine, thus blocking the enzymatic activity of these proteases. This compound is valuable in the study of inflammation and cell death pathways, particularly in research focused on the mechanisms of pyroptosis and other caspase-associated processes.
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  38. A25197
    Z-LEED-FMK

    Caspase Inhibitor

    Z-LEED-FMK is a selective inhibitor of caspase-4 and caspase-13. This compound effectively inhibits the processing of caspase-1 in macrophages infected with S. typhimurium, making it a valuable tool for studying apoptosis and inflammatory pathways. Its specificity and inhibitory effects are significant for research applications in cell death mechanisms and inflammatory response investigations.
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  39. A25198
    15-Acetoxyscirpenol

    Caspase Activator

    15-Acetoxyscirpenol is a potent caspase activator that induces apoptosis through the activation of multiple caspases, with effects that are independent of caspase-3. This mycotoxin significantly inhibits the growth of Jurkat T cells in a dose-dependent manner. Its ability to modulate apoptosis makes it a valuable tool for research in cancer biology and cell signaling pathways.
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  40. A25199
    Boc-AEVD-CHO

    Caspase 8 Inhibitor

    Boc-AEVD-CHO is a selective inhibitor of Caspase 8, a crucial enzyme involved in apoptotic pathways. This compound is valuable for investigating the mechanisms of apoptosis as well as the roles of Caspase 8 in various immune and inflammatory diseases. Researchers can utilize Boc-AEVD-CHO to better understand cellular processes related to programmed cell death and inflammation regulation.
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  41. A25200
    Z-YVAD-pNA

    Caspase-1 Substrate

    Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a substrate specifically designed for caspase-1 activity. This compound is pivotal in studying inflammation and cell death pathways, as it is cleaved by caspase-1 during the activation of inflammatory caspases. Z-YVAD-pNA serves as an essential tool in research focused on apoptosis, pyroptosis, and other caspase-related signaling mechanisms. Its use can aid in the development of therapeutic strategies targeting inflammatory diseases.
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  42. A25204
    Ac-VAD-pNA

    Caspase-1 Substrate

    Ac-VAD-pNA is a synthetic substrate specifically designed for the detection of caspase-1 activity. This compound enables the assessment of caspase-1 enzymatic function, making it a valuable tool for studying apoptotic and inflammatory pathways. Its utility in various research applications includes investigating mechanisms of cell death and inflammatory responses, facilitating advancements in therapeutic strategies targeting these processes.
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  43. A25206
    Mca-DEVDAP-K(Dnp)-OH

    Caspase-3 Fluorogenic Substrate

    Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate specifically designed for the quantification of caspase-3 activity. Utilizing the caspase-3 recognition sequence DEVD, this substrate facilitates the detection of caspase-3-mediated apoptosis in various biological samples. It is widely applied in research focused on programmed cell death and can be utilized in high-throughput screening assays to evaluate the efficacy of anti-apoptotic and pro-apoptotic compounds.
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  44. A25207
    Cimiside E

    Caspase 3 Inhibitor

    Cimiside E, a caspase 3 inhibitor, is a triterpene xyloside known for its pro-apoptotic effects on gastric cancer cells, displaying an IC50 value of 14.58 μM. This compound induces cell cycle arrest in the G2/M phase and mediates apoptosis via activation of the caspase cascade across both extrinsic and intrinsic pathways. Cimiside E is a valuable tool in cancer research, particularly in studies focusing on apoptosis and cell cycle modulation.
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  45. A25209
    IETD-CHO

    Caspase-8 Inhibitor

    IETD-CHO is a selective inhibitor of caspase-8, a crucial enzyme in the apoptotic signaling pathway. By blocking caspase-8 activity, this reagent prevents the activation of downstream effector caspases, allowing for the study of programmed cell death mechanisms. IETD-CHO is widely used in research applications focused on apoptosis, inflammation, and related cell signaling processes.
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  46. A25210
    Caspase-3 activator 3

    Caspase-3 Activator

    Caspase-3 activator 3 is a potent inducer of apoptosis, specifically targeting caspase-3 in HL-60 and K562 leukemia cell lines. This compound demonstrates significant antileukemic activity, with IC50 values of 42.89 μM for HL-60 cells and 33.61 μM for K562 cells. It serves as an important tool for investigating apoptotic pathways and evaluating potential therapeutic strategies in leukemia research.
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  47. A25212
    Ac-WEHD-AFC

    Caspase-1 Fluorogenic Substrate

    Ac-WEHD-AFC is a fluorogenic substrate specifically designed for the detection of caspase-1 activity. This compound enables the quantitative measurement of caspase-1 enzymatic function, making it a valuable tool in studies related to tumorigenesis and inflammatory processes. Its sensitive fluorescence readout facilitates the assessment of caspase-1 involvement in various biological systems.
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  48. A25271
    Caspase-9 Inhibitor III

    Caspase-9 Inhibitor

    Caspase-9 Inhibitor III (Ac-LEHD-cmk) targets and inhibits caspase-9, a critical component of the apoptotic pathway. This reagent demonstrates protective effects against ischemia-reperfusion-induced myocardial injury, making it valuable for studying cardiac apoptosis and related pathological conditions. It can be utilized in research focused on cellular survival mechanisms and the modulation of programmed cell death.
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  49. A25299
    Ac-FLTD-CMK

    Caspase Inhibitor

    Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases.
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  50. A25302
    Z-LEVD-FMK

    Caspase-4 inhibitor

    Z-LEVD-FMK is a cell-permeable inhibitor of caspase-4, a key player in the apoptotic signaling pathway. This reagent effectively blocks endoplasmic reticulum stress-induced apoptosis in cancer cells, making it a valuable tool for studying cell death mechanisms and developing therapeutic strategies in oncology research. Its specificity for caspase-4 facilitates investigations into its role in various cellular stress responses.
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