Caspase

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  1. Activator (3)
  2. Inhibitor (16)
  3. Substrate (2)


25 Item(s)

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Catalog No. Product Name Product Information
A15816

Ac-DEVD-CHO

Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.
A15319

Ac-IEPD-AFC

Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
A15291

Ac-LEHD-AFC

Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
A11944

Apoptosis Activator 2

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome.
A15294

AZ 10417808

AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 ??M).
A15392

Boc-D-FMK

BOC-D-FMK is a Novel inhibitor of Caspase-3.
A14919

Caspase-3/7 Inhibitor I

Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
A11394

Emricasan

Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases.
A14135

GDC-0152

GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.
A15300

Ivachtin

Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
A13070

LY573636 (Tasisulam)

LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
A14100

Nivocasan (GS-9450)

Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
A15391

NSC 687852

NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.
A11090

PAC-1

PAC-1 is first procaspase activating compound.
A15308

PETCM

PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
A14915

Q-VD-OPh hydrate

Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
A10984

VX-765 (Belnacasan)

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
A13503

Z-DEVD-FMK

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
A12697

Z-DQMD-FMK

Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
A12800

Z-IETD-FMK

Z-IETD-FMK is a specific inhibitor of caspase 8.
A14358

Z-LEHD-FMK

Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
A12373

Z-VAD-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
A12637

Z-VDVAD-FMK

Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
A12611

Z-VEID-FMK

Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2.
A14916

Z-WEHD-FMK

Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.

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