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- Ting TC, .et al. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15, Cell Rep, 2019, Nov 5;29(6):1499-1510.e6 PMID: 31693891
- Ting Han, .et al. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15, Science, 2017, Apr 28;356(6336). pii: eaal3755 PMID: 28302793
Biological Activity
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
Targets
Caspase | ||||
In vitro | DMSO | 73 mg/mL (175.85 mM) | |
Water | Insoluble | ||
Ethanol | 73 mg/mL | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.09 mL | 120.45 mL | 240.9 mL |
0.5 mM | 4.82 mL | 24.09 mL | 48.18 mL |
1 mM | 2.41 mL | 12.05 mL | 24.09 mL |
5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
*The above data is based on the productmolecular weight 415.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A13070 |
---|---|
Actions | Inducer |
CAS No. | 519055-62-0 |
Formula | C11H6BrCl2NO3S2 |
M. Wt | 415.11 |
Purity | >98% |
Synonyms | LY 573636, LY-573636 |
SMILES | C1=CC(=C(C=C1Cl)Cl)C(=O)NS(=O)(=O)C2=CC=C(S2)Br |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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