Dehydrogenases

Inhibitory Selectivity
Catalog No.Inhibitor Name Dehydrogenase
A10613Mycophenolate Mofetil
***
A12902AGI-5198
**
A11403MK-8245
****
A15892NCT-501
**
A15798SW033291
****
A12997Vidofludimus
*
A12903AGI-6780
***
A11786CPI-613
A10521Leflunomide
A10320Disulfiram
A10949Trilostane
A12899PluriSIn #1 (NSC 14613)
A10070Ammonium Glycyrrhizinate
A11682Gimeracil
A14795Gossypol Acetate
A10353Enoxolone
A10348Emodin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A15808

Enasidenib

IDH2 inhibitor
Enasidenib is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2).
A14386 SALE

AG-120

IDH1 inhibitor
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
A12925

JK 184

Hedgehog inhibitor
JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
A14412

ASP9521

-
ASP9521 is a novel, selective, orally bioavailable inhibitor of 17??-hydroxysteroid dehydrogenase type 5 (17bHSD5, AKR1C3).
A12997

Vidofludimus (4SC-101)

DHODH inhibitor
Vidofludimus is a novel orally active and potent DHODH inhibitor.
A13542

AZD4017

HSD1 inhibitor
AZD4017 is a potent, selective, and orally bioavailable11b-HSD1 inhibitor (11b-hydroxysteroid dehydrogenase type 1 inhibitor).
A14599

Monoammoniumglycyrrhizinate

-
Monoammoniumglycyrrhizinate is a constituent of the licorice root that has vital anti-viral activities that have been shown to inhibit the expression of 11_?HSD2 (11_?hydroxysteroid dehydrogenase type 2) via an indirect mechanism.
A15170

MK-8245 Trifluoroacetate

Liver-targeting SCD Inhibitor‎
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
A15798

SW033291

15-PGDH enzyme inhibitor
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
A15805 SALE

Alda 1

ALDH2 Activator
Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2).
A15892

NCT-501

hALDH1 Inhibitor‎
NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
A15869

AG-120

Dehydrogenase Inhibitor
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
A10949

Trilostane

-
Trilostane is an inhibitor of 3??-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.
A16164

Fomepizole

alcohol dehydrogenase inhibitor
Fomepizole is an alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisonings in adults.
A12903

AGI-6780

IDH2 R140Q inhibitor
AGI-6780 is a potent, selective inhibitor of mutant IDH2 with an IC50 value of 23 nM.
A12902 SALE

AGI-5198 (IDH-C35)

IDH1 inhibitor
AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.
A12385

CGP 3466B maleate

GAPDH inhibitor
CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor.
A10070

Ammonium Glycyrrhizinate (AMGZ)

Dehydrogenase inhibitor
Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste.
A10353

Glycyrrhetinic acid (Enoxolone)

15-PGDH inhibitor
Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive.
A11403 SALE

MK-8245

SCD inhibitor
MK-8245 is a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor. MK-8245 is useful for the Treatment of Diabetes and Dyslipidemia.
A10192 SALE

Celastrol

-

Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.

A10613 SALE

Mycophenolate mofetil (CellCept)

IMPDH inhibitor
Mycophenolate mofetil is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine biosynthesis (specifically guanine synthesis) which is necessary for the growth of T cells and B cells.
A10435 SALE

Gossypol

-
Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
A10521

Leflunomide

Dehydrogenase inhibitor
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs. Leflunomide is used to relieve symptoms caused by rheumatoid arthritis, such as inflammation, swelling, stiffness, and joint pain.
A11682 SALE

Gimeracil

-
Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination.
A11786 SALE

CPI-613

Dehydrogenase Inhibitor
CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities.
A10780 SALE

Ranolazine

-
Ranolazine is a partial fatty acid oxidation inhibitor, shifts ATP production from fatty acid to more oxygen-efficient carbohydrate oxidation.
A10320 SALE

Disulfiram

-
Disulfiram blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase thus causing an unpleasant reaction when alcohol is consumed.
A12442 SALE

Brequinar

Dihydroorotate Dehydrogenase Inhibitor
Brequinar is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis.
A16176

CBR 5884

PHGDH inhibitor
CBR 5884 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 33 uM.

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