Dehydrogenases



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Catalog No. Product Name Application Product Information
A14386

AG-120

IDH1 inhibitor
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
A12902

AGI-5198 (IDH-C35)

IDH1 inhibitor
AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.
A12903

AGI-6780

IDH2 R140Q inhibitor
AGI-6780 is a potent, selective inhibitor of mutant IDH2 with an IC50 value of 23 nM.
A12442

Brequinar

Dihydroorotate Dehydrogenase Inhibitor
Brequinar is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis.
A12385

CGP 3466B maleate

GAPDH inhibitor
CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor.
A11786

CPI-613

Dehydrogenase Inhibitor
CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities.
A15808

Enasidenib

IDH2 inhibitor
Enasidenib is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2).
A11682

Gimeracil

-
Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination.
A12925

JK 184

Hedgehog inhibitor
JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
A11403

MK-8245

SCD inhibitor
MK-8245 is a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor. MK-8245 is useful for the Treatment of Diabetes and Dyslipidemia.
A10780

Ranolazine

-
Ranolazine is a partial fatty acid oxidation inhibitor, shifts ATP production from fatty acid to more oxygen-efficient carbohydrate oxidation.

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