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Biological Activity
Sodium Dichloroacetate, also known as CPC-211; DCA; X-11S, is a Pyruvate dehydrogenase kinase inhibitor potentially for the treatment of myocardia ischemia, ischemic. Sodium dichloroacetate also exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3. Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.
| In vitro | DMSO | 27 mg/mL (178.9 mM) | |
| Water | 27 mg/mL (178.9 mM) | ||
| Ethanol | 27 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 66.26 mL | 331.3 mL | 662.6 mL |
| 0.5 mM | 13.25 mL | 66.26 mL | 132.52 mL |
| 1 mM | 6.63 mL | 33.13 mL | 66.26 mL |
| 5 mM | 1.33 mL | 6.63 mL | 13.25 mL |
*The above data is based on the productmolecular weight 150.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17862 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2156-56-1 |
| Formula | C2HCl2NaO2 |
| M. Wt | 150.92 |
| Purity | >98% |
| Synonyms | Sodium Dichloroacetate; CPC-211; DCA; X-11S; Dichloroacetic acid. |
| SMILES | O=C([O-])C(Cl)Cl.[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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