Sodium dichloroacetate (DCA)

Catalog No.: A17862

Pyruvate dehydrogenase kinase inhibitor

Sodium dichloroacetate (DCA)

Sodium dichloroacetate (DCA) Chemical Structure

CAS NO. 2156-56-1

Sodium Dichloroacetate, also known as CPC-211; DCA; X-11S, is a Pyruvate dehydrogenase kinase inhibitor potentially for the treatment of myocardia ischemia, ischemic. Sodium dichloroacetate also exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3. Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.

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500 mg
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Biological Activity

Sodium Dichloroacetate, also known as CPC-211; DCA; X-11S, is a Pyruvate dehydrogenase kinase inhibitor potentially for the treatment of myocardia ischemia, ischemic. Sodium dichloroacetate also exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3. Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.
In vitro DMSO 27 mg/mL (178.9 mM)
Water 27 mg/mL (178.9 mM)
Ethanol 27 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 66.26 mL 331.3 mL 662.6 mL
0.5 mM 13.25 mL 66.26 mL 132.52 mL
1 mM 6.63 mL 33.13 mL 66.26 mL
5 mM 1.33 mL 6.63 mL 13.25 mL

*The above data is based on the productmolecular weight 150.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17862
Actions Inhibitor
CAS No. 2156-56-1
Formula C2HCl2NaO2
M. Wt 150.92
Solubility DMSO
Purity >98%
Synonyms Sodium Dichloroacetate; CPC-211; DCA; X-11S; Dichloroacetic acid.
SMILES O=C([O-])C(Cl)Cl.[Na+]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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