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Fig. 1 · Structure
Cat. No.
A12442
CAS No.
96187-53-0
Formula
C22H13F2NO2
Mol. Weight
375.37

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Brequinar

Cat. No. A12442 CAS 96187-53-0

Dihydroorotate Dehydrogenase Inhibitor

Brequinar is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A-375 IC50 0.59 μM Antiproliferative activity against human A375 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay [PMID: 32496056]
A549 IC50 4.1 μM Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay [PMID: 32496056]
Bone marrow cell EC50 0.51 μM Induction of bone marrow cell differentiation isolated from ER-HOXA9 fusion protein expressed mouse harboring GFP-lysozyme assessed as upregulation of CD11b/MAC1 after 4 days by flow cytometry [PMID: 27994748]
HCT-116 IC50 0.679 μM Antiproliferative activity against human HCT116 cells over-expressing DHODH after 72 hrs by MTT assay [PMID: 29727569]
HCT-116 IC50 4.12 μM Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay [PMID: 32496056]
HeLa IC50 > 10 μM Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay [PMID: 32496056]
HL-60 IC50 0.544 μM Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay [PMID: 29727569]
HT-1080 IC50 0.21 μM Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay [PMID: 33007554]
HT-1080 IC50 17 μM Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay [PMID: 33007554]
HT-29 IC50 0.59 μM Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay [PMID: 33007554]
HT-29 IC50 24 μM Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay [PMID: 33007554]
Jurkat IC50 0.2 μM Inhibition of cell proliferation of human Jurkat cells incubated for 72 hrs by Celltiter-Glo assay [PMID: 26079043]
Jurkat IC50 0.91 μM Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye-based fluorescence assay [PMID: 29939742]
Jurkat IC50 0.93 μM Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye based fluorometric method [PMID: 28235702]
Jurkat IC50 94.17 μM Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs in presence of exogenous uridine by Hoechst 33258 dye-based fluorescence assay [PMID: 29939742]
K562 IC50 0.54 μM Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay [PMID: 32496056]
M21 IC50 0.57 μM Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay [PMID: 33007554]
M21 IC50 25 μM Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay [PMID: 33007554]
MCF7 IC50 > 10 μM Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay [PMID: 32496056]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 96187-53-0
Applications Dihydroorotate Dehydrogenase Inhibitor
Formula C22H13F2NO2
Molecular Weight 375.37
SMILES
CC1=C(N=C2C=CC(=CC2=C1C(=O)O)F)C3=CC=C(C=C3)C4=CC=CC=C4F

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 36 mg/mL (95.9 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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