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- Abdin AA, .et al. Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats., Eur J Pharmacol., 2014, 742:102-12 PMID: 25218987
|Storage||at -20°C 3 years Powder|
|SMILES||CC1=C(C(=O)C=C2C1=CC=C3[[email protected]]2(CC[[email protected]@]4([[email protected]@]3(CC[[email protected]@]5([[email protected]]4C[[email protected]](CC5)(C)C(=O)O)C)C)C)C)O|
|Chemical Name||3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid|
Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||22.19 mL||110.96 mL||221.93mL|
|0.5 mM||4.44 mL||22.19 mL||44.39 mL|
|1 mM||2.22 mL||11.1 mL||22.19 mL|
|5 mM||0.44 mL||2.22 mL||4.44 mL|
*The above data is based on the productmolecular weight 450.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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