DPP-4

Inhibitory Selectivity
Catalog No.Inhibitor Name DPP-4
A10848Sitagliptin phosphate monohydrate
**
A11224Linagliptin
****
A12528Vildagliptin (LAF-237)
***
A11109Saxagliptin
*
A13571Alogliptin
***
A14293Trelagliptin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



17 Item(s)

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Catalog No. Product Name Application Product Information
A15505

Teneligliptin

DPP-4 inhibitor
Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.
A15320

NVP DPP 728 dihydrochloride

DPP-4 inhibitor
NVP DPP 728 dihydrochloride is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively.
A15309

PK 44 phosphate

DPP-4 inhibitor
PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an IC50 value of 15.8 nM.
A15298

DPPI 1c hydrochloride

DPP-4 inhibitor
DPPI 1c hydrochloride is a dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of CD26 (DPP 4), with an IC50 = 106 nM and little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM.
A15258

Teneligliptin hydrobromide

DPP-4 inhibitor
Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.
A11109 SALE

Saxagliptin (BMS-477118)

DPP-4 Inhibitor
Saxagliptin (BMS-477118) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM.
A13529

Anagliptin

DPP-4 inhibitor
Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.
A13571

Alogliptin

DPP-4 inhibitor
Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
A14377

Sitagliptin

DDP-4 inhibitor
Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
A14293

Trelagliptin

DPP-4 inhibitor
Trelagliptin is a highly selective, long-acting DPP-4 inhibitor.
A13312

Trelagliptin Succinate (SYR-472)

DPP-4 inhibitor
Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).
A13311 SALE

Alogliptin Benzoate

DPP-4 inhibitor
Alogliptin Benzoate is a dipeptidyl-peptidase-4 (DPP 4) inhibitor
A13310 SALE

MK-3102

DPP-4 inhibitor
N/A
A12528 SALE

Vildagliptin

DPP-IV Inhibitor
Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor.
A11224 SALE

Linagliptin (BI-1356)

DPP-4 Inhibitor
Linagliptin is a DPP-4 inhibitor, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
A10848 SALE

Sitagliptin phosphate monohydrate

DDP-4 inhibitor
Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.
A16047

UAMC 00039 dihydrochloride

DPP-II inhibitor
UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively).

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