DNA-PK

Inhibitory Selectivity
Catalog No.Inhibitor Name DNA-PKOther
A10726PI-103
**
p110α,p110δ,p110β
A11098NU7441
***
mTOR,PI3K
A10729PIK-75
****
p110α,p110γ,p110δ
A12752NU7026
*
PI3K
A11207PP121
**
PDGFR,Hck,VEGFR
A13224KU-0060648
***
PI3Kδ,PI3Kβ,PI3Kα
A11778Compound 401
*
mTOR,PI3K
A13328ETP-46464
***
ATM, ATR, PI3Kα, mTOR
A15779CC-115
***
mTOR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A13224 SALE

KU 0060648

DNA-PK inhibitor
KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency.
A15779

CC-115

mTOR/DNA-PK inhibitor
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
A14136

NU6027

ATR/CDK inhibito
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
A12752 SALE

NU7026

DNA-PK inhibitor
NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
A13328

ETP-46464

ATR inhibitor
ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
A10726 SALE

PI-103

PI3K Inhibitor
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.
A11778

Compound 401

DNA-PK inhibitor
Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 ?M).
A10729

PIK-75

PI3K Inhibitor
PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
A11207 SALE

PP121

PI3K Inhibitor
PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
A11098 SALE

NU-7441 (KU-57788)

DNA-PK inhibitor
NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.
A16126

LY3023414

PI3K/mTOR Dual Inhibitor
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).

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