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NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
Targets
| DNA-PK (Cell-free assay) | PI3K (Cell-free assay) | ATM (Cell-free assay) | ATR (Cell-free assay) | |
| 0.23 μM | 13 μM | >100 μM | >100 μM |
| In vitro (25°C) | DMSO | 1 mg/mL (3.55 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.55 mL | 177.74 mL | 355.48 mL |
| 0.5 mM | 7.11 mL | 35.55 mL | 71.1 mL |
| 1 mM | 3.55 mL | 17.77 mL | 35.55 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.11 mL |
*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A12752 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 281.31 |
| Formula | C17H15NO3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 154447-35-5 |
| Synonyms | NU 7026, NU-7026 |
| SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3 |
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