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- Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789
- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
Biological Activity
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.
Targets
Target | Value |
---|---|
p110α | IC50: 2nM |
p110β | IC50: 3nM |
p110δ | IC50: 3nM |
p110γ | IC50: 15nM |
DNA-PK | IC50: 23nM |
mTOR | IC50: 30nM |
In vitro (25°C) | DMSO | 22 mg/mL (63.15 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 1 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 28.7 mL | 143.51 mL | 287.03 mL |
0.5 mM | 5.74 mL | 28.7 mL | 57.41 mL |
1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
*The above data is based on the productmolecular weight 348.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10726 |
---|---|
Actions | Inhibitor |
CAS No. | 371935-74-9 |
Formula | C19H16N4O3 |
M. Wt | 348.4 |
Purity | >98% |
Synonyms | PI103 |
SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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