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- Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789
- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
Biological Activity
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.
Targets
| Target | Value |
|---|---|
| p110α | IC50: 2nM |
| p110β | IC50: 3nM |
| p110δ | IC50: 3nM |
| p110γ | IC50: 15nM |
| DNA-PK | IC50: 23nM |
| mTOR | IC50: 30nM |
| In vitro (25°C) | DMSO | 22 mg/mL (63.15 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.7 mL | 143.51 mL | 287.03 mL |
| 0.5 mM | 5.74 mL | 28.7 mL | 57.41 mL |
| 1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
*The above data is based on the productmolecular weight 348.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10726 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 371935-74-9 |
| Formula | C19H16N4O3 |
| M. Wt | 348.4 |
| Purity | >98% |
| Synonyms | PI103 |
| SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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LY294002
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LY3023414
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NU-7441 (KU-57788)
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PI-3065
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PIK-75 hydrochloride
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PIK-93
PIK 93 selectively inhibits the type III PI 4-kinase enzyme, and small interfering RNA-mediated down-regulation of the individual PI 4-kinase enzymes. -
TGX-221
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XL147 analogue
XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity. -
YM201636
YM201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM). -
ZSTK474
ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms.
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