Catalog No.
Product Name
Application
Product Information
Citations
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Prostaglandin
1a,1b-Dihomo prostaglandin E1 is an analogue of prostaglandin that targets various prostaglandin receptors. This compound exhibits notable biological activities, influencing inflammation, vascular function, and cellular signaling pathways. It is primarily utilized in research applications related to cardiovascular studies, inflammation, and endocrinology, providing insights into prostaglandin-mediated physiological processes. -
Prostaglandin Analogue
Carboprost tromethamine is a synthetic analogue of prostaglandin F2α that primarily targets prostaglandin receptors. It is known for its ability to induce uterine contractions and effectively reduce bleeding during and after childbirth. This compound is commonly utilized in obstetric medicine to manage postpartum hemorrhage and facilitate labor. Its biological activity is critical in ensuring maternal safety and improving clinical outcomes in delivery situations. -
Prostaglandin Receptor
17-Phenyl trinor PGF2α isopropyl ester is a synthetic analog of F-series prostaglandins targeting the FP receptor. It exhibits potent agonistic activity, pivotal for reducing intraocular pressure (IOP), making it relevant in glaucoma research. In comparative studies, this compound has demonstrated significant IOP-lowering effects in animal models, outperforming other analogs while eliciting a pronounced irritant response. Its properties are key in exploring therapeutic options for ocular hypertension. -
PGD2 Analog
15(R)-15-Methyl prostaglandin D2 is a metabolically stable synthetic analog of PGD2 that selectively targets the CRTH2/DP2 receptor. This compound is known for its potent biological activities, including the regulation of eosinophil functions such as CD11b expression, actin polymerization, and chemotaxis, with EC50 values of 1.4, 3.8, and 1.7 nM, respectively. Its efficacy in these activities is significantly greater compared to natural PGD2. Additionally, 15(R)-15-Methyl prostaglandin D2 shows minimal action on the DP1 receptor, making it a valuable tool for research in immunology and inflammation studies. -
TxA2/PGH2 Receptor Antagonist
Ifetroban is an orally active antagonist of the thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) receptors. It exhibits significant antiplatelet activity and effectively inhibits tumor cell migration while leaving cell proliferation unaffected. This compound is applicable in research related to myocardial ischemia, hypertension, stroke, thrombosis, and cardiomyopathy. -
DP2 Antagonist
Pexopiprant is a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2), exhibiting a Ki value of less than 100 nM. This compound is primarily utilized in research related to asthma and other allergic inflammatory responses, where modulation of the DP2 pathway may provide therapeutic insights. Its ability to inhibit DP2 receptor activity positions Pexopiprant as a valuable tool for elucidating the role of prostaglandin signaling in various biological contexts. -
EP2 Agonist
Aganepag isopropyl is an EP2 receptor agonist that selectively stimulates the prostaglandin E2 receptor subtype 2. This compound plays a significant role in modulating inflammatory responses and vascular functions. Its utility in research includes exploring pathways related to pain perception, neuroinflammation, and potentially neuroprotective effects. Aganepag isopropyl serves as a valuable tool for studies investigating the role of EP2 in various physiological and pathological processes. -
NSAID
Droxicam is a non-steroidal anti-inflammatory drug (NSAID) primarily acting as an analgesic by inhibiting prostaglandin E2 (PGE2) synthesis. This pro-drug of Piroxicam exhibits significant anti-inflammatory properties and is noted for its favorable tolerance profile, with minimal mucosal side effects. In preclinical studies, Droxicam has demonstrated a lack of cardiovascular and respiratory effects in feline models, as well as the ability to inhibit peritoneal capillary permeability in murine subjects, making it suitable for various research applications in inflammation and pain. -
EP4 Receptor Antagonist
BGC-20-1531 free base is a selective antagonist of the prostanoid EP4 receptor, exhibiting a pKB of 7.6. This compound demonstrates potent inhibitory activity and is primarily utilized in research related to migraine headache mechanisms and treatments. Its specificity for the EP4 receptor makes it a valuable tool for exploring prostaglandin signaling pathways involved in pain modulation. -
sPLA2 Inhibitor
CAY10590 is a potent inhibitor of secreted phospholipase A2 (sPLA2), serving as a valuable tool for investigating the role of sPLA2 in chronic inflammatory kidney diseases. Its mechanism of action enables the modulation of inflammatory pathways, which is critical for understanding disease mechanisms and potential therapeutic interventions. This compound is applicable in preclinical research aimed at elucidating the involvement of sPLA2 in renal pathologies. -
PTGR2 Inhibitor
HHS-0701 is a potent inhibitor of prostaglandin reductase 2 (PTGR2), functioning as a sulfur-triazole exchange (SuTEx) ligand. This compound effectively blocks the metabolism of the lipid substrate 15-Keto-PGE2 by PTGR2, playing a crucial role in modulating prostaglandin levels. HHS-0701 is valuable for research applications involving inflammation and lipid metabolism, providing insights into the enzymatic regulation of prostaglandins. -
PGI2 Analogue
Taprostene is a synthetic analogue of Prostacyclin (PGI2) with enhanced chemical stability. It demonstrates protective effects on the endothelium and myocardium following acute myocardial ischemia and reperfusion, particularly in feline models. Taprostene's ability to promote cytoprotection while reducing adverse hemodynamic responses makes it a valuable investigational tool in cardiovascular research applications. -
Antithrombotic Agent
Etofylline clofibrate is an antithrombotic agent that primarily interacts with prostaglandin I2 (PGI2) in the vascular intima. This compound exhibits hypolipidemic properties, contributing to its role in lipid metabolism modulation. Its biological activities make it a valuable tool for research in cardiovascular diseases and thrombotic disorders. -
EP4 Antagonists
AMX12006 is a selective EP4 antagonist that exhibits a potent inhibitory effect with an IC50 value of 4.3 nM. This compound demonstrates notable cytotoxic and antitumor activity, making it a valuable tool for research in cancer biology and therapeutic applications targeting the prostaglandin E receptor pathway. Its oral bioavailability enhances its utility in preclinical studies. -
Endogenous Hormone
Prostaglandin F2α serinol amide is a G protein-coupled receptor that targets the endogenous hormone pathway, effectively increasing intracellular calcium levels in human non-small cell lung cancer cells. This compound plays a critical role in various biological processes, including its function as a luteinizing hormone in ovine species and its potential role as a nociceptive mediator within the spinal cord. Its biological activity makes it a valuable tool for research in cancer biology and neurobiology. -
Prostaglandin Receptor
Thromboxane B1 (TXB1) is a prominent member of the thromboxane family and acts primarily on prostaglandin receptors. This eicosanoid plays a critical role in regulating platelet aggregation and vascular tone, making it essential in the study of thrombotic disorders. TXB1 is widely utilized in research applications related to cardiovascular biology and the assessment of vascular responses, contributing to our understanding of various pathophysiological conditions. -
Racemate
(±)5-iPF2α-VI is a racemic isoprostane derived from arachidonic acid, primarily acting as a biomarker for oxidative stress. This compound is important for investigating oxidative damage and lipid peroxidation in biological systems. It serves as a valuable tool in research applications focused on inflammation, cardiovascular diseases, and cellular stress responses. -
TP Receptor Antagonist
TP Receptor Antagonist-3 (compound 51280) is a potent antagonist of the thromboxane A2 receptor (TP), exhibiting an IC50 of 15.7 nM against human TP. This compound is valuable for investigating disease mechanisms in Alzheimer's disease, cardiovascular conditions, and respiratory disorders, as well as cancer research applications. Its ability to selectively inhibit TP receptor signaling makes it an important tool for exploring therapeutic interventions in these areas. -
Luteolytic Agent
Cloprostenol is a synthetic analogue of prostaglandin F2α (PGF2α) that serves as a luteolytic agent. It effectively induces luteolysis, making it valuable for research in reproductive biology and veterinary medicine, particularly in studies involving open-cervix pyometra. This compound is essential for exploring mechanisms of luteal regression and hormonal regulation in various biological contexts. -
EP1 Receptor Antagonist
SC 51089 is a selective antagonist of the prostaglandin E2 EP1 receptor, characterized by binding affinities with Kis of 1.3 μM for EP1, and higher affinities for TP, EP3, and FP receptors, with Kis of 11.2, 17.5, and 61.1 μM, respectively. This compound has demonstrated neuroprotective activity, making it valuable for research applications focused on neuroinflammation and pain signaling pathways. SC 51089 offers potential insights into EP1 receptor-related diseases and therapeutic interventions. -
Antioxidant
Cyanidin is a potent antioxidant and enzyme inhibitor targeting cyclooxygenases PGHS-1 and PGHS-2, with IC50 values of 90 μM and 60 μM, respectively. This compound exhibits significant antioxidant and anti-inflammatory properties, effectively scavenging free radicals, inhibiting lipid peroxidation, and protecting DNA from oxidative damage. Cyanidin is valuable for research into inflammatory diseases and related therapeutic applications. -
Vasodilator
19(R)-HETE is a potent vasodilator that primarily acts on renal arteries. Its biological activity is significant in modulating vascular tone and blood flow, making it a valuable tool for studies related to renal function and hypertension. Researchers can utilize 19(R)-HETE to investigate its effects on vascular smooth muscle relaxation and the underlying signaling pathways involved in renal circulation. -
EP1 Receptor Antagonist
ONO-8711 is a selective competitive antagonist of the EP1 receptor, with Ki values of 0.6 nM for human and 1.7 nM for mouse EP1. This compound has demonstrated significant efficacy in reducing tumor incidence and multiplicity in mouse models of colon, breast, and oral cancers. ONO-8711 is valuable for research applications related to cancer biology and the modulation of EP1 receptor signaling pathways. -
Racemic Isomer of Beraprost sodium
(Rac)-Beraprost sodium is a racemic isomer of the prostacyclin analog Beraprost sodium, primarily targeting prostacyclin receptors. It effectively inhibits calcium release from intracellular stores, promoting smooth muscle relaxation and vasodilation. With notable vasodilatory, antiplatelet, and cytoprotective properties, (Rac)-Beraprost sodium serves as a valuable tool for research into cardiovascular diseases, including thromboangiitis obliterans and atherosclerosis. -
Prostaglandin FP Receptor Agonist
Bimatoprost acid is a potent agonist of the prostaglandin FP receptor. As the acid hydrolysis product of Bimatoprost, it exhibits significant biological activity in modulating intraocular pressure. This compound is utilized in research applications aimed at investigating ocular pharmacology and the mechanisms underlying glaucoma treatments. -
the Trans Isomer of Latanoprost
trans-Latanoprost is the trans isomer of Latanoprost, primarily targeting the prostaglandin FP receptor. This compound exhibits potent biological activity in reducing intraocular pressure, making it a valuable research tool in the study of glaucoma and other ocular conditions associated with elevated eye pressure. Its unique structural properties allow for potential exploration in therapeutic applications and ocular pharmacology. -
DP(2) Receptor Agonist
15(R)-Prostaglandin D2 is an agonist of the DP(2) receptor, identified as a prostatic hormone with anti-inflammatory properties. This compound enhances actin polymerization in human eosinophils and elevates cAMP levels in platelets, making it valuable for research in inflammation and immune response mechanisms. Its utility extends to studying the role of prostaglandins in various biological processes and pathways. -
Thromboxane A2 Receptor Antagonist
Sulotroban is a selective antagonist of the thromboxane A2 receptor (TXA2). It effectively inhibits vasoconstriction induced by carbocyclic thromboxane A2 and endoperoxides, while also demonstrating the ability to inhibit platelet aggregation. This compound is of particular interest in cardiovascular research, where modulation of thromboxane A2 signaling may hold therapeutic potential for various vascular conditions. -
Thromboxane A2 Receptor Ligand
8-Isoprostaglandin E2 (iPE2-III) is a potent ligand for the thromboxane A2 receptor (TP). It is known to induce vasoconstriction and promote platelet aggregation, making it significant in vascular biology and hemostasis research. Additionally, 8-Isoprostaglandin E2 enhances the RANKL-dependent osteoclastic activity of marrow hematopoietic precursors through the cAMP signaling pathway, positioning it as a valuable agent in studies of bone metabolism and related disorders. -
Prostaglandin E3/F Receptor Agonist
Sepetaprost is a dual agonist of the prostaglandin E3 and F receptors, primarily targeting ocular health. It exhibits significant biological activity in reducing intraocular pressure, making it a valuable compound for research into ocular hypertension and open-angle glaucoma. This agent is instrumental in studying mechanisms of action related to eye disorders and potential therapeutic strategies. -
Prostaglandin Receptor Antagonist
BAY-6672 is a potent and selective antagonist of the human Prostaglandin F (FP) receptor, exhibiting an IC50 value of 11 nM. This compound effectively inhibits FP receptor-mediated signaling, making it a valuable tool for studies of prostaglandin-related biological processes. BAY-6672 is primarily utilized in research exploring inflammation, reproductive biology, and cardiovascular functions associated with prostaglandin signaling pathways. -
DP Receptor Antagonist
Laropiprant sodium is a potent and selective antagonist of the DP receptor, exhibiting Ki values of 0.57 nM for the DP receptor and 2.95 nM for the TP receptor. This compound is utilized in research to explore its effects on inflammatory processes and vascular function due to its role in modulating prostaglandin signaling. Its high selectivity makes it a valuable tool for investigating DP receptor-mediated pathways in various biological contexts. -
Prostaglandin Analog
17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide is a lipophilic prostaglandin analog designed to interact with prostaglandin receptors. This compound exhibits biological activity related to modulation of vascular tone and smooth muscle contraction. It serves as a valuable tool in research applications focused on cardiovascular function and reproductive biology, enabling the investigation of prostaglandin signaling pathways and their implications in various physiological processes. -
AR Antagonist
(+) -JJ-450 is a non-competitive antagonist of the androgen receptor (AR), effectively inhibiting AR nuclear localization and transcriptional activity in the absence of androgen. This compound promotes the degradation of unliganded AR within the nucleus, thereby reducing the binding of AR to androgen response elements (AREs), including its splice variants like ARv7. With lower efficacy than its counterpart, (-)-JJ-450, in suppressing prostate-specific antigen (PSA) expression in LN95 cells, (+)-JJ-450 is particularly relevant for research focused on castration-resistant prostate cancer (CRPC) that exhibits resistance to enzalutamide. -
Latanoprost Derivative
9-Keto-latanoprost is a derivative of the F-prostaglandin (FP) receptor agonist, Latanoprost. This compound exhibits significant biological activity by selectively activating FP receptors, which plays a crucial role in regulating intraocular pressure. 9-Keto-latanoprost is primarily utilized in research applications focused on glaucoma treatment and ocular pharmacology, providing insights into prostaglandin signaling pathways and their therapeutic implications. -
Prostaglandin Inhibitor
Ibuprofen guaiacol ester is a potent inhibitor of prostaglandin synthesis, demonstrating significant oral bioactivity. It is primarily utilized in research related to inflammation, edema, and fever modulation. This compound provides valuable insights into the mechanistic pathways of pain and inflammatory responses, making it a useful tool in pharmacological studies. -
Vasopressor
11-deoxy Prostaglandin F1α is a potent vasopressor compound that serves as an analog of prostaglandin F1α. This reagent demonstrates significant biological activity, including the stimulation of uterine contractions and bronchoconstriction. Its mechanisms make it valuable for research applications involving vascular function and respiratory responses. -
EP4 Agonist
CCI17464 is a selective, orally active EP4 partial agonist with a pKi of 7.1. This compound demonstrates significant biological activity in the modulation of inflammatory responses and has been effectively utilized in the Freund's complete adjuvant (FCA) acute rat inflammatory pain model. CCI17464 shows promise in the complete reversal of allergic reactions, making it a valuable tool for research in inflammation and allergic responses. -
Prostaglandin Receptor
AL 8810 isopropyl ester is a potent and selective antagonist of the FP receptor, functioning as an 11β-fluoro analog of prostaglandin F2α. This lipid-soluble, esterified prodrug form enhances the compound's bioavailability, making it suitable for research applications targeting ocular pharmacology and the modulation of intraocular pressure. AL 8810 isopropyl ester is designed for investigations related to prostaglandin receptor signaling pathways and therapeutic interventions in glaucoma treatment. -
Bimatoprost acid Derivative
17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid that primarily targets the prostaglandin EP receptor. This compound exhibits potent biological activity in promoting ocular hypotensive effects, making it relevant for studies on glaucoma and intraocular pressure regulation. Its unique fluorinated structure may also enhance binding affinity and selectivity, facilitating research in pharmacology and therapeutic development related to eye disorders. -
Prostacyclin Receptor Agonist
AFP-07 is a potent and selective agonist of the prostacyclin receptor (IP receptor), with a Ki value of 0.561 nM. This compound is utilized in research focusing on cardiovascular biology and inflammation, offering insights into prostacyclin-mediated signaling pathways. Its strong affinity makes it suitable for studying the therapeutic potential of prostacyclin analogs in various disease models. -
Cloprostol
(+)-5-trans Cloprostenol is a synthetic derivative of prostaglandin F2α, primarily targeting prostaglandin pathways. This compound is associated with various biological activities related to reproductive physiology and is commonly utilized in veterinary medicine for its role in managing reproductive disorders in cattle, pigs, and horses. As a secondary impurity produced during the synthesis of (+)-cloprostenol, its contribution to overall effects and applications in reproductive research should be considered. -
CRTh2 Antagonist
ARRY-502 is a potent and selective antagonist of the CRTh2 receptor, demonstrating oral bioavailability. By inhibiting PGD2-mediated Th2 inflammation, ARRY-502 effectively blocks eosinophil activation and airway hyperresponsiveness. This reagent holds significant potential for research applications focused on Th2-related asthma and related inflammatory disorders. -
Prostaglandin Analog
17-Phenyl trinor prostaglandin A2 is a synthetic analog of prostaglandin that primarily targets the prostaglandin pathway. This compound exhibits significant biological activity, influencing various physiological processes such as vasodilation and platelet aggregation. It is commonly utilized in research applications focusing on cardiovascular function, inflammation, and related signaling pathways. -
Latanoprost Metabolite
15-Keto latanoprost is a metabolite of latanoprost, primarily functioning as an ocular hypotensive agent. This compound is used extensively in research to investigate its effects on intraocular pressure and its mechanisms of action in glaucoma treatment. Its role as a biomarker and its influence on prostaglandin pathways make it a valuable tool for studying ocular pharmacology and therapeutic interventions in eye diseases. -
Isomer
5,6-trans-Bimatoprost is an isomer of Bimatoprost, primarily used as an experimental control in research. As a prostaglandin analogue, it plays a significant role in studies related to ocular hypertension and glaucoma. Additionally, 5,6-trans-Bimatoprost exhibits anti-adipogenic properties, making it relevant for investigations into fat formation and metabolic processes. -
TXA₂ Receptor Antagonist
ICI 185282 is a selective thromboxane A2 (TXA₂) receptor antagonist that exhibits potent, orally active inhibition. It effectively reduces U-46619-induced platelet aggregation in a dose-dependent manner in guinea pig models. Additionally, ICI 185282 demonstrates efficacy in preventing bronchospasm triggered by various inflammatory mediators such as PGD2, PGF2α, arachidonic acid, LTD4, and PAF in vivo. This compound is valuable for research in bronchial asthma and related respiratory conditions. -
Isomer
trans-Latanoprost acid is an isomer of Latanoprost acid, primarily targeting the reduction of intraocular pressure. This compound exhibits significant biological activity in studies focused on ocular diseases. It is predominantly utilized as an analytical standard for the detection and quantification of impurities in pharmaceutical formulations. -
EP2 Receptor Agonist
Evatanepag sodium is a potent and selective agonist of the EP2 receptor, functioning as a non-prostanoid compound. This reagent has been shown to induce local bone formation in vivo, making it valuable for research into fractures and bone defects. Additionally, Evatanepag sodium is applicable in studies related to asthma, providing insights into its potential therapeutic effects in respiratory conditions. -
Prostaglandin Analog
Prostaglandin E1 alcohol is a prostaglandin analog that functions as a potent vasodilator. It is known to enhance blood flow and has applications in research related to cardiovascular diseases and tissue perfusion. This compound is also utilized in studies exploring its effects on smooth muscle relaxation and receptor signaling pathways.
