Fig. 1 · Structure
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SC 51089
EP1 Receptor Antagonist
SC 51089 is a selective antagonist of the prostaglandin E2 EP1 receptor, characterized by binding affinities with Kis of 1.3 μM for EP1, and higher affinities for TP, EP3, and FP receptors, with Kis of 11.2, 17.5, and 61.1 μM, respectively. This compound has demonstrated neuroprotective activity, making it valuable for research applications focused on neuroinflammation and pain signaling pathways. SC 51089 offers potential insights into EP1 receptor-related diseases and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 146033-02-5 |
| Applications | EP1 Receptor Antagonist |
| Formula | C22H20Cl2N4O3 |
| Molecular Weight | 459.33 |
| SMILES | O=C(N1C2=CC(Cl)=CC=C2OC3=CC=CC=C3C1)NNC(CCC4=CC=NC=C4)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.