Fig. 1 · Structure
Documents & Downloads
AMX12006
EP4 Antagonists
AMX12006 is a selective EP4 antagonist that exhibits a potent inhibitory effect with an IC50 value of 4.3 nM. This compound demonstrates notable cytotoxic and antitumor activity, making it a valuable tool for research in cancer biology and therapeutic applications targeting the prostaglandin E receptor pathway. Its oral bioavailability enhances its utility in preclinical studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2639775-01-0 |
| Applications | EP4 Antagonists |
| Formula | C26H22F3N3O3 |
| Molecular Weight | 481.47 |
| SMILES | O=C(N[C@@H](C)C1=CC=C(C(O)=O)C=C1)C2=C(C3=CC=CC=C3N2C)NC4=CC(C(F)(F)F)=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.