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ONO-8711

EP1 Receptor Antagonist

ONO-8711 is a selective competitive antagonist of the EP1 receptor, with Ki values of 0.6 nM for human and 1.7 nM for mouse EP1. This compound has demonstrated significant efficacy in reducing tumor incidence and multiplicity in mouse models of colon, breast, and oral cancers. ONO-8711 is valuable for research applications related to cancer biology and the modulation of EP1 receptor signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	216158-34-8
Applications	EP1 Receptor Antagonist
Formula	C₂₂H₃₀ClNO₄S
Molecular Weight	440.00
SMILES	O=C(O)CCC/C=C\[C@H]1C(CC2)CCC2[C@@H]1CNS(=O)(C3=CC=C(Cl)C=C3C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.