Fig. 1 · Structure
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Pexopiprant
DP2 Antagonist
Pexopiprant is a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2), exhibiting a Ki value of less than 100 nM. This compound is primarily utilized in research related to asthma and other allergic inflammatory responses, where modulation of the DP2 pathway may provide therapeutic insights. Its ability to inhibit DP2 receptor activity positions Pexopiprant as a valuable tool for elucidating the role of prostaglandin signaling in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 932708-14-0 |
| Applications | DP2 Antagonist |
| Formula | C21H17Cl2F2NO4 |
| Molecular Weight | 456.27 |
| SMILES | O=C(O)COC1=C2C(OC(F)F)=C(CC3=CC=C(Cl)C=C3)C(CC)=NC2=C(Cl)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.